DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stip1 and stip1

DIOPT Version :9

Sequence 1:	NP_477354.1	Gene:	Stip1 / 33202	FlyBaseID:	FBgn0024352	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001007767.1	Gene:	stip1 / 493606	ZFINID:	ZDB-GENE-041121-17	Length:	542	Species:	Danio rerio

Alignment Length:	549	Identity:	270/549 - (49%)
Similarity:	357/549 - (65%)	Gaps:	68/549 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDKVNELKEKGNQALSAEKFDEAVAAYTEAIALDDQNHVLYSNRSAAFAKAGKFQEALEDAEKTI 65
            |:||::||::||:||||...:||:..||||:.||..||||:||||||:||.|.:..||:||.:||
Zfish     1 MEKVSQLKDQGNKALSAGNLEEAIRCYTEALTLDPSNHVLFSNRSAAYAKKGDYDNALKDACQTI 65

  Fly    66 QLNPTWPKGYSRKGAAAAGLNDFMKAFEAYNEGLKYDPTNAILLQG--RMETTASALSFM----- 123
            ::.|.|.||||||.||...|.....|...|.|||:.:|:|..|.:|  .||...:....|
Zfish    66 KIKPDWGKGYSRKAAALEFLGRLEDAKATYQEGLRQEPSNQQLKEGLQNMEARLAEKKMMNPFSI 130

  Fly   124 -----QSQGDI---PMDVDP------QQARSR-------------------------------RA 143
                 :.:||.   .:..||      :|.|::                               ..
Zfish   131 PNLYEKLEGDSRTRALLSDPSYRELLEQLRNKPSELGTKLQDPRVMTTLSVLLGLDLSGMDEEEE 195

  Fly   144 PSPPPAKPAEPPKPAE-----PRVEDMTEEQKNKYFARKEKELGNAAYKKKDFETALKHYHAAIE 203
            |:|||     ||||.|     |:.||:.|   ||..|.|||||||||||||||.||||||..||:
Zfish   196 PTPPP-----PPKPKETAPPPPKEEDLPE---NKRMALKEKELGNAAYKKKDFATALKHYEEAIK 252

  Fly   204 HDPTDITFYNNIAAVHFERKEYEECIKQCEKGIEVGRESRADFKLIAKSFARIGNTYRKLENYKQ 268
            ||||::|:.:|.|||:||:.::::|.:.|||.|:||||:|.|::.|||::|||||:|.|.|.||:
Zfish   253 HDPTNMTYLSNQAAVYFEKGDFDKCRELCEKAIDVGRENREDYRQIAKAYARIGNSYFKQEKYKE 317

  Fly   269 AKVYYEKAMSEHRTPEIKTSLSEVEAKIKEEERMAYINPEKAEEEKEQGNLFFKKGDYSTAVKHY 333
            |..::.|:::|||||::.....|.|..:||:|::|||||:.|.|||.:||..|:||||..|:|||
Zfish   318 AVQFFNKSLTEHRTPDVLKKCQEAEKILKEQEKVAYINPDLALEEKNKGNDAFQKGDYPLAMKHY 382

  Fly   334 TEAIKRNPDDPKLYSNRAACYTKLAAFDLGLKDCDTCIKLDEKFIKGYIRKGKILQGMQQQSKAQ 398
            :|||||||.|.||:||||||||||..|.|.||||:.||.||..|||||.|||..|:.|:..|||.
Zfish   383 SEAIKRNPYDAKLFSNRAACYTKLLEFQLALKDCEECINLDSTFIKGYTRKGAALEAMKDFSKAM 447

  Fly   399 AAYQKALELDPNNAEAIEGYRQCSMN-FQRN--PQEVLKNAMSDPEIQQILKDPAMRMILEQMQS 460
            ..||||||||.|:.||.||.::|.:: ..||  |::|.:.||:|||:|||:.||||||||||||.
Zfish   448 DVYQKALELDSNSKEATEGLQRCMVSQAMRNDSPEDVKRRAMADPEVQQIMSDPAMRMILEQMQK 512

  Fly   461 DPNAVKEHLQNPAIADKIMKLLESGIIQI 489
            ||.|:.:||:||.||.||.||::.|:|.|
Zfish   513 DPQALSDHLKNPVIAQKIQKLIDVGLIAI 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stip1	NP_477354.1	TPR_11	6..69	CDD:290150	35/62 (56%)
		TPR repeat	7..32	CDD:276809	14/24 (58%)
		TPR repeat	37..67	CDD:276809	19/29 (66%)
		TPR_11	40..103	CDD:290150	32/62 (52%)
		TPR repeat	72..100	CDD:276809	13/27 (48%)
		TPR_11	175..237	CDD:290150	39/61 (64%)
		TPR repeat	175..203	CDD:276809	23/27 (85%)
		TPR_1	181..208	CDD:278916	22/26 (85%)
		TPR_12	205..278	CDD:290160	36/72 (50%)
		TPR repeat	208..238	CDD:276809	12/29 (41%)
		TPR repeat	250..278	CDD:276809	14/27 (52%)
		TPR_1	250..>276	CDD:278916	13/25 (52%)
		TPR_11	309..375	CDD:290150	44/65 (68%)
		TPR repeat	310..338	CDD:276809	17/27 (63%)
		TPR_1	<317..343	CDD:278916	18/25 (72%)
		TPR repeat	343..373	CDD:276809	21/29 (72%)
		TPR_1	378..411	CDD:278916	20/32 (63%)
		TPR repeat	378..406	CDD:276809	16/27 (59%)
		STI1	439..478	CDD:128966	27/38 (71%)
stip1	NP_001007767.1	TPR_11	7..69	CDD:290150	35/61 (57%)
		TPR	7..37	CDD:197478	16/29 (55%)
		TPR repeat	7..32	CDD:276809	14/24 (58%)
		TPR repeat	37..67	CDD:276809	19/29 (66%)
		TPR_11	40..103	CDD:290150	32/62 (52%)
		TPR repeat	72..100	CDD:276809	13/27 (48%)
		TPR_11	224..285	CDD:290150	39/60 (65%)
		TPR repeat	228..252	CDD:276809	20/23 (87%)
		TPR_1	230..257	CDD:278916	22/26 (85%)
		TPR_12	254..327	CDD:290160	36/72 (50%)
		TPR repeat	257..287	CDD:276809	12/29 (41%)
		TPR	299..327	CDD:197478	14/27 (52%)
		TPR repeat	299..326	CDD:276809	14/26 (54%)
		TPR_11	359..423	CDD:290150	43/63 (68%)
		TPR repeat	363..387	CDD:276809	14/23 (61%)
		TPR repeat	392..422	CDD:276809	21/29 (72%)
		TPR_1	427..459	CDD:278916	20/31 (65%)
		TPR repeat	427..455	CDD:276809	16/27 (59%)
		STI1	491..530	CDD:128966	27/38 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8816
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4965
Inparanoid	1	1.050	495	1.000	Inparanoid score	I1350
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D387926at33208
OrthoFinder	1	1.000	-	-		FOG0001589
OrthoInspector	1	1.000	-	-		oto41606
orthoMCL	1	0.900	-	-		OOG6_102012
Panther	1	1.100	-	-	LDO	PTHR22904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1407
SonicParanoid	1	1.000	-	-		X2280
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.860