DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stip1 and sti1

DIOPT Version :9

Sequence 1:	NP_477354.1	Gene:	Stip1 / 33202	FlyBaseID:	FBgn0024352	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_588123.1	Gene:	sti1 / 2539474	PomBaseID:	SPCC645.14c	Length:	591	Species:	Schizosaccharomyces pombe

Alignment Length:	590	Identity:	226/590 - (38%)
Similarity:	317/590 - (53%)	Gaps:	109/590 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELKEKGNQALSAEKFDEAVAAYTEAIALDDQNHVLYSNRSAAFAKAGKFQEALEDAEKTIQLNPT 70
            |||.|||.|.|.:.:..|:..:|:||.||::||:|||||||.:|....:.:||:||.|..:|.|.
pombe     4 ELKAKGNAAFSKKDYKTAIDYFTQAIGLDERNHILYSNRSACYASEKDYADALKDATKCTELKPD 68

  Fly    71 WPKGYSRKGAAAAGLNDFMKAFEAYNEGLKYDPTNAILLQGR----------------------- 112
            |.||:||||||..||.|...|..||.||||:|..||.||.|.
pombe    69 WAKGWSRKGAALHGLGDLDAARSAYEEGLKHDANNAQLLNGLKSVEAAQTQAASGAGGFNPFAKL 133

  Fly   113 ---------ME------TTASAL---SFM-------QSQGDIPMDV-DPQQ-------------- 137
                     ||      .|||.|   :||       |:.|.|..:: ||:.
pombe   134 GSQLSDPKFMEKLASNPETASLLADSAFMAKLQKIQQNPGSIMAELNDPRMMKVIGMLMGIDINM 198

  Fly   138 ----------------ARSRRAPSPPPAKPA---EPPKP--AEPRVEDMTEEQ----------KN 171
                            |.|...||...|||.   .||:|  :||..||.|.|:          |.
pombe   199 NAGEGAAEEQEKKEEFAPSSSTPSADSAKPETTNPPPQPQASEPMEEDKTAEELEEAATKEALKK 263

  Fly   172 KYFARKEKELGNAAYKKKDFETALKHYHAAIEHDPTDITFYNNIAAVHFERKEYEECIKQCEKGI 236
            |  |.:||::||..|||::|..|::.|..|.: ...|||:.||:||.:||..:.::|||.||..|
pombe   264 K--ADQEKQIGNENYKKRNFPVAIEQYKKAWD-TYKDITYLNNLAAAYFEADQLDDCIKTCEDAI 325

  Fly   237 EVGRESRADFKLIAKSFARIGNTYRKLENYKQAKVYYEKAMSEHRTPEIKTSLSEVEAKIKEEER 301
            |.|||.|||||||||:..|:|.||:|..:..:|..||:::::|||||:|.:.|.:.|...:.::|
pombe   326 EQGRELRADFKLIAKALGRLGTTYQKRGDLVKAIDYYQRSLTEHRTPDILSRLKDAEKSKELQDR 390

  Fly   302 MAYINPEKAEEEKEQGNLFFKKGDYSTAVKHYTEAIKRNPDDPKLYSNRAACYTKLAAFDLGLKD 366
            .|||:|:||||.:.:||..||.||::.|:|.|||..||.|.||:.:.||||.|.|:.|....::|
pombe   391 EAYIDPDKAEESRVKGNELFKSGDFANAIKEYTEMTKRAPSDPRGFGNRAAAYLKVMAPAECIRD 455

  Fly   367 CDTCIKLDEKFIKGYIRKGKILQGMQQQSKAQAAYQKALELD---PN---NAEAIEG-YRQC--S 422
            |:..|:||..|.|.|:||.:.|..::..:|...|..:|.|:|   ||   |...||. ..:|  :
pombe   456 CNKAIELDPNFAKAYVRKAQALFMLKDYNKCIDACNEASEVDRREPNTGKNLREIESQLSKCMSA 520

  Fly   423 MNFQR---NPQEVLKNAMSDPEIQQILKDPAMRMILEQMQSDPNAVKEHLQNPAIADKIMKLLES 484
            |..||   ..:|.:.....|||:..||:||||:.||.|.:.:|.|:.||::||.:..||.||:.|
pombe   521 MASQRQNETEEETMARIQKDPEVLGILQDPAMQAILGQARENPAALMEHMKNPTVKSKIEKLIAS 585

  Fly   485 GIIQI 489
            |:|::
pombe   586 GVIRL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stip1	NP_477354.1	TPR_11	6..69	CDD:290150	30/62 (48%)
		TPR repeat	7..32	CDD:276809	10/24 (42%)
		TPR repeat	37..67	CDD:276809	15/29 (52%)
		TPR_11	40..103	CDD:290150	34/62 (55%)
		TPR repeat	72..100	CDD:276809	16/27 (59%)
		TPR_11	175..237	CDD:290150	26/61 (43%)
		TPR repeat	175..203	CDD:276809	12/27 (44%)
		TPR_1	181..208	CDD:278916	9/26 (35%)
		TPR_12	205..278	CDD:290160	36/72 (50%)
		TPR repeat	208..238	CDD:276809	15/29 (52%)
		TPR repeat	250..278	CDD:276809	10/27 (37%)
		TPR_1	250..>276	CDD:278916	10/25 (40%)
		TPR_11	309..375	CDD:290150	31/65 (48%)
		TPR repeat	310..338	CDD:276809	14/27 (52%)
		TPR_1	<317..343	CDD:278916	14/25 (56%)
		TPR repeat	343..373	CDD:276809	12/29 (41%)
		TPR_1	378..411	CDD:278916	12/38 (32%)
		TPR repeat	378..406	CDD:276809	8/27 (30%)
		STI1	439..478	CDD:128966	18/38 (47%)
sti1	NP_588123.1	TPR_11	2..67	CDD:290150	30/62 (48%)
		TPR_1	2..35	CDD:278916	14/30 (47%)
		TPR repeat	2..30	CDD:276809	11/25 (44%)
		TPR repeat	35..65	CDD:276809	15/29 (52%)
		TPR_11	38..100	CDD:290150	34/61 (56%)
		TPR repeat	70..98	CDD:276809	16/27 (59%)
		TPR_11	264..326	CDD:290150	27/64 (42%)
		TPR repeat	265..293	CDD:276809	12/27 (44%)
		TPR repeat	297..327	CDD:276809	15/29 (52%)
		TPR_12	298..367	CDD:290160	35/68 (51%)
		TPR_1	339..>366	CDD:278916	10/26 (38%)
		TPR repeat	339..366	CDD:276809	10/26 (38%)
		TPR_11	398..464	CDD:290150	31/65 (48%)
		TPR repeat	399..427	CDD:276809	14/27 (52%)
		TPR repeat	432..462	CDD:276809	12/29 (41%)
		TPR_1	433..466	CDD:278916	13/32 (41%)
		TPR_11	438..497	CDD:290150	22/58 (38%)
		TPR repeat	467..495	CDD:276809	8/27 (30%)
		STI1	540..579	CDD:128966	18/38 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	53	1.000	Domainoid score	I3273
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4965
Inparanoid	1	1.050	283	1.000	Inparanoid score	I659
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001589
OrthoInspector	1	1.000	-	-		oto101207
orthoMCL	1	0.900	-	-		OOG6_102012
Panther	1	1.100	-	-	LDO	PTHR22904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1407
SonicParanoid	1	1.000	-	-		X2280
TreeFam	1	0.960	-	-
	13	12.850