DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stip1 and Stip1

DIOPT Version :9

Sequence 1:	NP_477354.1	Gene:	Stip1 / 33202	FlyBaseID:	FBgn0024352	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_058017.1	Gene:	Stip1 / 20867	MGIID:	109130	Length:	543	Species:	Mus musculus

Alignment Length:	547	Identity:	277/547 - (50%)
Similarity:	348/547 - (63%)	Gaps:	63/547 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDKVNELKEKGNQALSAEKFDEAVAAYTEAIALDDQNHVLYSNRSAAFAKAGKFQEALEDAEKTI 65
            |::|||||||||:||||...|:|:..|:|||.||.||||||||||||:||.|.:|:|.||..||:
Mouse     1 MEQVNELKEKGNKALSAGNIDDALQCYSEAIKLDPQNHVLYSNRSAAYAKKGDYQKAYEDGCKTV 65

  Fly    66 QLNPTWPKGYSRKGAAAAGLNDFMKAFEAYNEGLKYDPTNAILLQG--RMETTASALSFM----- 123
            .|.|.|.||||||.||...||.|.:|...|.||||::..|..|.:|  .||...:...||
Mouse    66 DLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNLQLKEGLQNMEARLAERKFMNPFNL 130

  Fly   124 ---------------------------QSQGDIPMDV-----DPQ----------------QARS 140
                                       |.|.. |.|:     ||:                ....
Mouse   131 PNLYQKLENDPRTRSLLSDPTYRELIEQLQNK-PSDLGTKLQDPRVMTTLSVLLGVDLGSMDEEE 194

  Fly   141 RRAPSPPPAKPAEPPKPAEPRVEDMTEEQKNKYFARKEKELGNAAYKKKDFETALKHYHAAIEHD 205
            ..|..|||..|.:.||| ||..||:.|   ||..|.|||||||.|||||||:.|||||..|.|.|
Mouse   195 EAATPPPPPPPKKEPKP-EPMEEDLPE---NKKQALKEKELGNDAYKKKDFDKALKHYDRAKELD 255

  Fly   206 PTDITFYNNIAAVHFERKEYEECIKQCEKGIEVGRESRADFKLIAKSFARIGNTYRKLENYKQAK 270
            ||::|:..|.||||||:.:|.:|.:.|||.||||||:|.|::.|||::|||||:|.|.|.||.|.
Mouse   256 PTNMTYITNQAAVHFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAI 320

  Fly   271 VYYEKAMSEHRTPEIKTSLSEVEAKIKEEERMAYINPEKAEEEKEQGNLFFKKGDYSTAVKHYTE 335
            .:|.|:::|||||::.....:.|..:||:||:|||||:.|.|||.:||..|:||||..|:|||||
Mouse   321 HFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTE 385

  Fly   336 AIKRNPDDPKLYSNRAACYTKLAAFDLGLKDCDTCIKLDEKFIKGYIRKGKILQGMQQQSKAQAA 400
            ||||||.|.|||||||||||||..|.|.||||:.||:|:..|||||.||...|:.|:..:||...
Mouse   386 AIKRNPRDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDV 450

  Fly   401 YQKALELDPNNAEAIEGYRQCSM---NFQRNPQEVLKNAMSDPEIQQILKDPAMRMILEQMQSDP 462
            |||||:||.:..||.:||::|.|   |...:|::|.:.||:|||:|||:.|||||:||||||.||
Mouse   451 YQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDP 515

  Fly   463 NAVKEHLQNPAIADKIMKLLESGIIQI 489
            .|:.|||:||.||.||.||::.|:|.|
Mouse   516 QALSEHLKNPVIAQKIQKLMDVGLIAI 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stip1	NP_477354.1	TPR_11	6..69	CDD:290150	41/62 (66%)
		TPR repeat	7..32	CDD:276809	15/24 (63%)
		TPR repeat	37..67	CDD:276809	20/29 (69%)
		TPR_11	40..103	CDD:290150	37/62 (60%)
		TPR repeat	72..100	CDD:276809	15/27 (56%)
		TPR_11	175..237	CDD:290150	38/61 (62%)
		TPR repeat	175..203	CDD:276809	21/27 (78%)
		TPR_1	181..208	CDD:278916	19/26 (73%)
		TPR_12	205..278	CDD:290160	40/72 (56%)
		TPR repeat	208..238	CDD:276809	14/29 (48%)
		TPR repeat	250..278	CDD:276809	15/27 (56%)
		TPR_1	250..>276	CDD:278916	14/25 (56%)
		TPR_11	309..375	CDD:290150	46/65 (71%)
		TPR repeat	310..338	CDD:276809	18/27 (67%)
		TPR_1	<317..343	CDD:278916	19/25 (76%)
		TPR repeat	343..373	CDD:276809	22/29 (76%)
		TPR_1	378..411	CDD:278916	17/32 (53%)
		TPR repeat	378..406	CDD:276809	14/27 (52%)
		STI1	439..478	CDD:128966	27/38 (71%)
Stip1	NP_058017.1	TPR 1	4..37		21/32 (66%)
		TPR_11	6..69	CDD:290150	41/62 (66%)
		TPR	7..37	CDD:197478	18/29 (62%)
		TPR repeat	7..32	CDD:276809	15/24 (63%)
		TPR repeat	37..67	CDD:276809	20/29 (69%)
		TPR 2	39..71		20/31 (65%)
		TPR_11	40..100	CDD:290150	35/59 (59%)
		TPR repeat	72..100	CDD:276809	15/27 (56%)
		TPR 3	73..105		17/31 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..233		21/41 (51%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	222..239		7/16 (44%)
		TPR_11	224..287	CDD:290150	34/62 (55%)
		TPR 4	225..258		19/32 (59%)
		TPR repeat	229..253	CDD:276809	14/23 (61%)
		TPR_1	231..258	CDD:278916	17/26 (65%)
		TPR_12	255..328	CDD:290160	38/72 (53%)
		TPR repeat	258..288	CDD:276809	14/29 (48%)
		TPR 5	260..292		13/31 (42%)
		TPR 6	300..333		20/32 (63%)
		TPR	300..328	CDD:197478	18/27 (67%)
		TPR repeat	300..328	CDD:276809	18/27 (67%)
		TPR_11	360..425	CDD:290150	33/67 (49%)
		TPR 7	360..393		18/32 (56%)
		TPR_1	364..393	CDD:278916	16/28 (57%)
		TPR repeat	364..388	CDD:276809	14/23 (61%)
		TPR_11	393..458	CDD:290150	34/67 (51%)
		TPR repeat	393..423	CDD:276809	14/29 (48%)
		TPR_1	394..427	CDD:278916	16/35 (46%)
		TPR 8	395..427		16/34 (47%)
		TPR 9	428..461		21/32 (66%)
		TPR repeat	428..456	CDD:276809	16/27 (59%)
		STI1	492..531	CDD:128966

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8867
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4965
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001589
OrthoInspector	1	1.000	-	-		oto93467
orthoMCL	1	0.900	-	-		OOG6_102012
Panther	1	1.100	-	-	LDO	PTHR22904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1407
SonicParanoid	1	1.000	-	-		X2280
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.850