DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Stip1 and TOMM34

DIOPT Version :9

Sequence 1:NP_477354.1 Gene:Stip1 / 33202 FlyBaseID:FBgn0024352 Length:490 Species:Drosophila melanogaster
Sequence 2:NP_006800.2 Gene:TOMM34 / 10953 HGNCID:15746 Length:309 Species:Homo sapiens


Alignment Length:328 Identity:82/328 - (25%)
Similarity:130/328 - (39%) Gaps:75/328 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 PRVEDMTEEQK---NKYFARKEKELGNAAYKKKDFETALKHYHAAIEHDP-TDITFYNNIAAVHF 220
            |:..|..||.:   |:.|...:....:|.|.:     ||:...|....|| .:...|:|.||.|.
Human     3 PKFPDSVEELRAAGNESFRNGQYAEASALYGR-----ALRVLQAQGSSDPEEESVLYSNRAACHL 62

  Fly   221 ERKEYEECIKQCEKGIEVGRESRADFKLIAKSFARIGNTYRKLENYKQAKVYYE----------- 274
            :.....:|||.|...:.:     ..|.:  |...|..:.|..||.|..|.|.|:           
Human    63 KDGNCRDCIKDCTSALAL-----VPFSI--KPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTS 120

  Fly   275 ---------KAMSEHRTPEIKTSLSEVE---------------------AKIKEEERMAYIN--- 306
                     :|:.:...||.:..|..:.                     ||.|.:|..|..|   
Human   121 AVEGINRMTRALMDSLGPEWRLKLPSIPLVPVSAQKRWNSLPSENHKEMAKSKSKETTATKNRVP 185

  Fly   307 ----PEKAEEEKEQGNLFFKKGDYSTAVKHYTEAIKRNPDDPKLYSNRAACYTKLAAFDLGLKDC 367
                .|||...||:||...|||::..|::.|:|::..:..:...|||||.||..|..:...:|||
Human   186 SAGDVEKARVLKEEGNELVKKGNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVKDC 250

  Fly   368 DTCIKLDEKFIKGYIRKGKILQGMQQQSKAQAAYQKALELDPNNAEAIEGYRQCSMNFQRNPQEV 432
            ...:|||.|.:|.:.|:.:..:.::....:.|.....|:::|.|..|           |:..|||
Human   251 TEALKLDGKNVKAFYRRAQAHKALKDYKSSFADISNLLQIEPRNGPA-----------QKLRQEV 304

  Fly   433 LKN 435
            .:|
Human   305 KQN 307

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Stip1NP_477354.1 TPR_11 6..69 CDD:290150
TPR repeat 7..32 CDD:276809
TPR repeat 37..67 CDD:276809
TPR_11 40..103 CDD:290150
TPR repeat 72..100 CDD:276809
TPR_11 175..237 CDD:290150 16/62 (26%)
TPR repeat 175..203 CDD:276809 5/27 (19%)
TPR_1 181..208 CDD:278916 7/27 (26%)
TPR_12 205..278 CDD:290160 22/93 (24%)
TPR repeat 208..238 CDD:276809 9/29 (31%)
TPR repeat 250..278 CDD:276809 10/47 (21%)
TPR_1 250..>276 CDD:278916 9/45 (20%)
TPR_11 309..375 CDD:290150 25/65 (38%)
TPR repeat 310..338 CDD:276809 11/27 (41%)
TPR_1 <317..343 CDD:278916 8/25 (32%)
TPR repeat 343..373 CDD:276809 11/29 (38%)
TPR_1 378..411 CDD:278916 5/32 (16%)
TPR repeat 378..406 CDD:276809 3/27 (11%)
STI1 439..478 CDD:128966
TOMM34NP_006800.2 TPR 1 9..42 8/37 (22%)
TPR repeat 9..37 CDD:276809 7/32 (22%)
PLN03088 <12..>294 CDD:330826 71/293 (24%)
TPR repeat 50..80 CDD:276809 9/29 (31%)
TPR 2 51..84 9/37 (24%)
TPR repeat 85..113 CDD:276809 9/29 (31%)
TPR 3 86..118 9/31 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..189 6/27 (22%)
TPR 4 193..226 11/32 (34%)
TPR repeat 193..221 CDD:276809 11/27 (41%)
TPR repeat 226..256 CDD:276809 11/29 (38%)
TPR 5 227..260 14/32 (44%)
TPR repeat 261..289 CDD:276809 3/27 (11%)
TPR 6 262..294 5/31 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155697
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53129
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

Return to query results.
Submit another query.