Protein Alignment Stip1 and TOMM34

DIOPT Version :10

• Sequence 1: NP_477354.1
• Gene: Stip1 / 33202
• FlyBaseID: FBgn0024352
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_006800.2
• Gene: TOMM34 / 10953
• HGNCID: 15746
• Length: 309
• Species: Homo sapiens
• Alignment Length: 328
• Identity: 82/328 - (25%)
• Similarity: 130/328 - (39%)
• Gaps: 75/328 - (22%)

  Fly   160 PRVEDMTEEQK---NKYFARKEKELGNAAYKKKDFETALKHYHAAIEHDP-TDITFYNNIAAVHF 220
            |:..|..||.:   |:.|...:....:|.|.:     ||:...|....|| .:...|:|.||.|.
Human     3 PKFPDSVEELRAAGNESFRNGQYAEASALYGR-----ALRVLQAQGSSDPEEESVLYSNRAACHL 62

  Fly   221 ERKEYEECIKQCEKGIEVGRESRADFKLIAKSFARIGNTYRKLENYKQAKVYYE----------- 274
            :.....:|||.|...:.:     ..|.:  |...|..:.|..||.|..|.|.|:
Human    63 KDGNCRDCIKDCTSALAL-----VPFSI--KPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTS 120

  Fly   275 ---------KAMSEHRTPEIKTSLSEVE---------------------AKIKEEERMAYIN--- 306
                     :|:.:...||.:..|..:.                     ||.|.:|..|..|
Human   121 AVEGINRMTRALMDSLGPEWRLKLPSIPLVPVSAQKRWNSLPSENHKEMAKSKSKETTATKNRVP 185

  Fly   307 ----PEKAEEEKEQGNLFFKKGDYSTAVKHYTEAIKRNPDDPKLYSNRAACYTKLAAFDLGLKDC 367
                .|||...||:||...|||::..|::.|:|::..:..:...|||||.||..|..:...:|||
Human   186 SAGDVEKARVLKEEGNELVKKGNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVKDC 250

  Fly   368 DTCIKLDEKFIKGYIRKGKILQGMQQQSKAQAAYQKALELDPNNAEAIEGYRQCSMNFQRNPQEV 432
            ...:|||.|.:|.:.|:.:..:.::....:.|.....|:::|.|..|           |:..|||
Human   251 TEALKLDGKNVKAFYRRAQAHKALKDYKSSFADISNLLQIEPRNGPA-----------QKLRQEV 304

  Fly   433 LKN 435
            .:|
Human   305 KQN 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stip1	NP_477354.1	TPR repeat	7..32	CDD:276809
		TPR	10..276	CDD:440225	32/139 (23%)
		TPR repeat	37..67	CDD:276809
		TPR repeat	72..100	CDD:276809
		LapB	173..415	CDD:442196	71/290 (24%)
		TPR repeat	175..203	CDD:276809	5/27 (19%)
		TPR repeat	208..238	CDD:276809	9/29 (31%)
		TPR repeat	250..278	CDD:276809	10/47 (21%)
		TPR repeat	310..338	CDD:276809	11/27 (41%)
		TPR repeat	343..373	CDD:276809	11/29 (38%)
		TPR repeat	378..406	CDD:276809	3/27 (11%)
		STI1	429..482	CDD:436075	4/7 (57%)
TOMM34	NP_006800.2	TPR 1	9..42		8/37 (22%)
		TPR repeat	9..37	CDD:276809	7/32 (22%)
		3a0801s09	<12..>294	CDD:273380	71/293 (24%)
		TPR repeat	50..80	CDD:276809	9/29 (31%)
		TPR 2	51..84		9/37 (24%)
		TPR repeat	85..113	CDD:276809	9/29 (31%)
		TPR 3	86..118		9/31 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..189		6/27 (22%)
		TPR 4	193..226		11/32 (34%)
		TPR repeat	193..221	CDD:276809	11/27 (41%)
		TPR repeat	226..256	CDD:276809	11/29 (38%)
		TPR 5	227..260		14/32 (44%)
		TPR repeat	261..289	CDD:276809	3/27 (11%)
		TPR 6	262..294		5/31 (16%)