DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment U2af38 and U2af1

DIOPT Version :9

Sequence 1:	NP_001259814.1	Gene:	U2af38 / 33201	FlyBaseID:	FBgn0017457	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_001157241.1	Gene:	U2af1 / 108121	MGIID:	98884	Length:	239	Species:	Mus musculus

Alignment Length:	253	Identity:	188/253 - (74%)
Similarity:	205/253 - (81%)	Gaps:	16/253 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRIHNKPTFSQTVLLQNLYVNPQNSAKSADGS 65
            |||||||||||||||||||||||||||||||||||:|||||||||:|:||:|.||||||::||||
Mouse     1 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTILIQNIYRNPQNSAQTADGS 65

  Fly    66 HLVANVSDEEMQEHYDNFFEDVFVECEDKYGEIEEMNVCDNLGDHLVGNVYIKFRNEADAEKAAN 130
            |..  |||.|||||||.|||:||.|.|:||||:||||||||||||||||||:|||.|.|||||..
Mouse    66 HCA--VSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRREEDAEKAVI 128

  Fly   131 DLNNRWFGGRPVYSELSPVTDFREACCRQYEMGECTRSGFCNFMHLKPISRELRRYLYSRRRRAR 195
            |||||||.|:|:::|||||||||||||||||||||||.|||||||||||||||||.||.|||: :
Mouse   129 DLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRRRK-K 192

  Fly   196 SRSRSPGRRRGSRSRSRSPGRRGGGRGDGVGGGNYLNNERDNMRGNDRGNDRDRRKGG 253
            .||||..|.|.||||.|.   ||||.|.|.|||          |..||...|||.:.|
Mouse   193 HRSRSRSRERRSRSRDRG---RGGGGGGGGGGG----------RERDRRRSRDRERSG 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
U2af38	NP_001259814.1	zf-CCCH	13..39	CDD:279036	24/25 (96%)
		RRM_U2AF35	43..148	CDD:240982	77/104 (74%)
		zf-CCCH	151..177	CDD:279036	24/25 (96%)
U2af1	NP_001157241.1	zf-CCCH	13..39	CDD:395517	24/25 (96%)
		RRM_U2AF35	43..146	CDD:409954	77/104 (74%)
		zf-CCCH	149..175	CDD:395517	24/25 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837921
Domainoid	1	1.000	94	1.000	Domainoid score	I7453
eggNOG	1	0.900	-	-		E1_KOG2202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14345
Inparanoid	1	1.050	375	1.000	Inparanoid score	I2068
Isobase	1	0.950	-	0	Normalized mean entropy	S1692
OMA	1	1.010	-	-		QHG56320
OrthoDB	1	1.010	-	-		D1340384at2759
OrthoFinder	1	1.000	-	-		FOG0002537
OrthoInspector	1	1.000	-	-		otm43764
orthoMCL	1	0.900	-	-		OOG6_101418
Panther	1	1.100	-	-	LDO	PTHR12620
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4380
SonicParanoid	1	1.000	-	-		X1660
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750