DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSP90AA1 and Gp93

DIOPT Version :9

Sequence 1:	NP_001017963.2	Gene:	HSP90AA1 / 3320	HGNCID:	5253	Length:	854	Species:	Homo sapiens
Sequence 2:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	336/734 - (45%)
Similarity:	479/734 - (65%)	Gaps:	39/734 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   137 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHIN 201
            |:.:.|.||.|:.::|.||||:.|.||||||||||||:|||:||||..:|::..:|::..||||.
  Fly    70 EKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIR 134

Human   202 LIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ-----AGADIS-MIGQFGVGF 260
            :..:|:::.|.|:|:|||||..||||||||||||||..|:..:|     .|.|:: |||||||||
  Fly   135 IKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGF 199

Human   261 YSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTD-TGEPMGRGTKVILHLKEDQTEYLEERR 324
            |||:|||::|.|.||||||:||.|||.| .||::..| .|:.:.||:.:.|:|||:..::|||..
  Fly   200 YSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQDFLEEDT 263

Human   325 IKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEE 389
            ::|:::|:||||.:||.::..|..::||          ..||:.|.|| |||..|.||...:|.|
  Fly   264 VRELIRKYSQFINFPIRMWSSKTVEEEV----------PVEEEAKPEK-SEDDVEDEDAKVEEAE 317

Human   390 EKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVE 454
            :    :|.|.||:.:...|...:|.:||||||.|.::|.:||..||||||.|..:.|...||..|
  Fly   318 D----EKPKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAE 378

Human   455 GQLEFRALLFVPRRAPFDLFENR--KKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLP 517
            |::.|::||:||:..|.:.| ||  .|.:|||||||||||.|...:::|.||:||||||||:|||
  Fly   379 GEVTFKSLLYVPKVQPSESF-NRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLP 442

Human   518 LNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLS 582
            ||:|||.|||.|::|||:|.||:|.|::..::  |||.|:||:::||.|||||:.||..||.:|:
  Fly   443 LNVSRETLQQHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSRLA 505

Human   583 ELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPI 647
            :|||:.|| :|..:.||.:|..|||..|:|||||.|..:.:|..|.|||||...|.||:|::|.:
  Fly   506 KLLRFQTS-NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAV 569

Human   648 DEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDI-LEKKVEKVVVS 711
            ||||:..|.||:||...:|.|||.:|.|.|:.||..|..|:.||.|.|.:.|: |:.::.|..||
  Fly   570 DEYCISALPEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVS 634

Human   712 NRLVTSPCCIVTSTYGWTANMERIMKAQALR---DNSTMGYMAAKKHLEINPDHSIIETLRQKAE 773
            .||..|||.:|...:|||.||||:..:.|.:   |.....|:..||.|||||.|.::..|.::.|
  Fly   635 ERLSNSPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVE 699

Human   774 ADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPT------ADDTSA 832
            ||:.|.:.||:.::::.||.|.||:.|::....|:.|.:|::..||:.:|:..      .||...
  Fly   700 ADEADDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDAEE 764

Human   833 AVTEEMPPLEGDDDTSRME 851
            ..|........||:....:
  Fly   765 TATGSQESGNADDEEEEQQ 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSP90AA1	NP_001017963.2	PTZ00272	140..854	CDD:240341	335/731 (46%)
		HATPase_c	162..313	CDD:214643	88/157 (56%)
		HSP90	318..844	CDD:278607	232/537 (43%)
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	327/690 (47%)
		HATPase_c	97..216	CDD:238030	69/118 (58%)
		HSP90	257..748	CDD:278607	228/509 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720