DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Amnionless and AMN

DIOPT Version :9

Sequence 1:	NP_001259813.1	Gene:	Amnionless / 33199	FlyBaseID:	FBgn0025686	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	XP_024305482.1	Gene:	AMN / 81693	HGNCID:	14604	Length:	485	Species:	Homo sapiens

Alignment Length:	545	Identity:	115/545 - (21%)
Similarity:	177/545 - (32%)	Gaps:	189/545 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGLHWQWLIW-ALVGLHVALATKWYGGGMDFNDPTAWLDDHLPCAQDLVVFPEYYPALLPLPEDI 64
            ||:..:.|:| .|..|..|::..|. ...||:....|..:..|||...|.||......:.:.|..
Human    33 MGVLGRVLLWLQLCALTQAVSKLWV-PNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGH 96

  Fly    65 SIDGLVFPREGAILLAEESTITFG-SD--KQPSCESDENKAYLKPPKSSKWFDPGTWTDKSKEFS 126
            ::..::.|.:|.::||  |...|| ||  ....|.:.|...:....:.| |.||..|....:...
Human    97 AVSDMLLPLDGELVLA--SGAGFGVSDVGSHLDCGAGEPAVFRDSDRFS-WHDPHLWRSGDEAPG 158

  Fly   127 TFTPELERIPCDDEQVIIK-------GHGPLAFDLENVQYLRLGQLILAGSSISKTYLEQLISRD 184
            .|..:.||:||..:.|...       |.||.|..:.          :.:.|::.:|:..   ..|
Human   159 LFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVR----------VRSISALGRTFTR---DED 210

  Fly   185 LGQFLFYNAEYVQVEYYRG--------ELC----GCHKDFERLLEPVCHNVQEQ----------- 226
            |..||...|..::   :.|        |.|    ||          ||.|.:.|
Human   211 LAVFLASRAGRLR---FHGPGALSVGPEDCADPSGC----------VCGNAEAQPWICAALLQPL 262

  Fly   227 ---CETPHCLSPVRPLGSCCLICGAILSTPTTHCTEGSRKELVAQISNLISQESLKDQIGLHVEF 288
               |....|.|.:||.|.||.:|||::.  .||
Human   263 GGRCPQAACHSALRPQGQCCDLCGAVVL--LTH-------------------------------- 293

  Fly   289 VGSQKFGNCLQAVVTDRHKYSERSLE-FLQQNEHNWNKTGTTLKVSGRPYNPNVSFSSIVLILFC 352
                       ....|..:|..|.|: ||...:::    |..:.||..|.:..:..:...:
Human   294 -----------GPAFDLERYRARILDTFLGLPQYH----GLQVAVSKVPRSSRLREADTEI---- 339

  Fly   353 MALVGLVSVVILAHFMPENPYLNRIPQWIHDPRLWRWRHLGLRLRRNLLFNRFDNGGAEG----- 412
                    .|:|....||.....                   ||.|.||.:..:||.|.|
Human   340 --------QVVLVENGPETGGAG-------------------RLARALLADVAENGEALGVLEAT 377

  Fly   413 ---------GSSEGGASG-------VDRLGIMAYDP---ESGEVRER------------AFDNPM 446
                     |||..|.:|       :..|.::...|   .:|.:|.|            .|.||:
Human   378 MRESGAHVWGSSAAGLAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPV 442

  Fly   447 FEQGGALEEAAKESQEQDEILSVPK 471
            |:     ..|::|......:..|||
Human   443 FD-----VTASEELPLPRRLSLVPK 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amnionless	NP_001259813.1	Amnionless	21..448	CDD:291494	102/499 (20%)
AMN	XP_024305482.1	Amnionless	54..479	CDD:317263	108/524 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160470
Domainoid	1	1.000	58	1.000	Domainoid score	I10847
eggNOG	1	0.900	-	-		E1_28N9A
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D356731at33208
OrthoFinder	1	1.000	-	-		FOG0008021
OrthoInspector	1	1.000	-	-		oto91037
orthoMCL	1	0.900	-	-		OOG6_108642
Panther	1	1.100	-	-	LDO	PTHR14995
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5573
SonicParanoid	1	1.000	-	-		X5974
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740