DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and Fzd10

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_780493.1	Gene:	Fzd10 / 93897	MGIID:	2136761	Length:	582	Species:	Mus musculus

Alignment Length:	515	Identity:	137/515 - (26%)
Similarity:	231/515 - (44%)	Gaps:	79/515 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 DLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITM 176
            :|.....::|...:|:::..|... .|.:.::.|||:::.|.| |:::    ..:|:   ||:..
Mouse    55 NLMGHENQREAAIQLHEFAPLVEY-GCHSHLRFFLCSLYAPMCTEQVS----TPIPA---CRVMC 111

  Fly   177 EPCR-----ILYNTTF-FPKFLRCNETLFPTK---------CTNGARGMKFNGTGQCLSPLVPTD 226
            |..|     |:....| :|..|.|::  .|.|         ..|........|:|. ..||....
Mouse   112 EQARLKCSPIMEQFKFRWPDSLDCSK--LPNKNDPNYLCMEAPNNGSDEPSRGSGM-FPPLFRPQ 173

  Fly   227 T--SASYY------PGIEGC-----------GVRCKDPLYT---------DDEHRQIHKLIGWAG 263
            .  ||..:      ||..||           ...|. ||.|         ||:...:..|..|:
Mouse   174 RPHSAQEHPLKDGGPGRAGCDNPGKFHHVEKSESCA-PLCTPGVDVYWSRDDKRFAVVWLAIWS- 236

  Fly   264 SICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLRH 328
            .:|..|:.|.|.||.|| .:..:||...:.::::|:.:..||::::..:|: |.|.|.:|....:
Mouse   237 VLCFFSSAFTVLTFLID-PSRFRYPERPIIFLSMCYCVYSVGYIIRLFAGA-ESIACDRDSGQLY 299

  Fly   329 SEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGSYFHLVAWSL 390
            ......|:..|.::|:::|||..|..:|:|.||..|...|   .||  :.|:...|||||.||::
Mouse   300 VIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGH--EAIEANSSYFHLAAWAI 362

  Fly   391 PLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHF 455
            |.|.||..:....|.|:.:.|:|:||.::.:...|.:|.||...::||..||..|.|.||.::.
Mouse   363 PAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRR- 426

  Fly   456 ANDIKSTSASN--KIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSV 518
               :..|...|  |:..:::|:||.:||..|.....|||:..|..:.|.|.....|. .||:::.
Mouse   427 ---VMKTGGENTDKLEKLMVRIGVFSLLYTVPATCVIACYFYERLNMDYWKMLATQH-KCKMNNQ 487

  Fly   519 FEEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETW--------KRYIRKK 570
            .:........:.|:|.|..:.:..|...||....|.||..::::|        ||..|:|
Mouse   488 TKTPDCLMTTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQHVCSRGLKRKSRRK 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	26/123 (21%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	99/343 (29%)
Fzd10	NP_780493.1	CRD_FZ	31..157	CDD:295308	24/111 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..189		7/36 (19%)
		Frizzled	219..536	CDD:279827	95/326 (29%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	527..532		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..582
		PDZ-binding	580..582
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820