DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and FZD9

DIOPT Version :10

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_003499.1 Gene:FZD9 / 8326 HGNCID:4047 Length:591 Species:Homo sapiens


Alignment Length:651 Identity:145/651 - (22%)
Similarity:254/651 - (39%) Gaps:134/651 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LCLWVVADASASSAKFGSTTPASAQQSDVELEPINGTLNYRLYAKKGRDDKPWFDGLDSRHIQCV 85
            |.||.:..|..::.:.|...|                       ::||...|         .|.|
Human    10 LLLWQLLAAGGAALEIGRFDP-----------------------ERGRGAAP---------CQAV 42

  Fly    86 RRARCYPTSNATNTCFGSKLPYELSSLDLTDFHTEK-ELNDKLNDYYALKHVPKCWAAIQPFLCA 149
            ....|            ..:.|.|:.:.....||.: |...:|.::..|... .|.:.::.|||:
Human    43 EIPMC------------RGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQY-GCHSHLRFFLCS 94

  Fly   150 VFKPKC-EKINGEDMVYLPSYEMCRITMEPCRILYNTTFFPKFLRC------------------N 195
            ::.|.| ::::.......|..|..|:...|....:|.. :|..|.|                  |
Human    95 LYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFG-WPDSLDCARLPTRNDPHALCMEAPEN 158

  Fly   196 ETLFPTKCTNG----------AR-----GMKFNGTGQCLSPLVPTDTSASYYPGIEGCGVRCKDP 245
            .|..|.:...|          ||     |....|:|.|.:|     ....|......|..||...
Human   159 ATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENP-----EKFQYVEKSRSCAPRCGPG 218

  Fly   246 LYTDDEHRQIHKLIGWA---GSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWL 307
            :......|.....:.|.   .::|..|..|.|.||.:: .:..:||...:.::::|:.:..:.:|
Human   219 VEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLE-PHRFQYPERPIIFLSMCYNVYSLAFL 282

  Fly   308 LQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---M 369
            ::..:|: :.:.|.::....:......||..|.::|:|:|||..|..:|:|.||..|...|   .
Human   283 IRAVAGA-QSVACDQEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKW 346

  Fly   370 GHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGV 434
            ||  :.|:..|||||:.||.||.:.||..:...:|.|:.:.|:|:|...:.:...|.:|.||.|.
Human   347 GH--EAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGY 409

  Fly   435 ILIGGYFITRGMVMLFGLKHFANDIKSTSASN--KIHLIIMRMGVCALLTLVFILVAIACHVTEF 497
            :::|..|:..|.|.||.::    .|..|..:|  |:..:::::||.::|..|.....|.|:|.|.
Human   410 LVLGSSFLLTGFVALFHIR----KIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYER 470

  Fly   498 RHADEW-AQSFRQFIICKISSVFEEKSSCRIE--NRPSVGVLQLHLLCLFSSGIVMSTWCWTPSS 559
            .:.|.| .::..|  .|..::....:..|.:.  :.|:|.|..|.:......||....|.|:..:
Human   471 LNMDFWRLRATEQ--PCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKT 533

  Fly   560 IETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRL-----------SITLYNTHTD 613
            .:||:....:|                ||...|:.|.....|..           ::.|:.|.||
Human   534 FQTWQSLCYRK----------------IAAGRARAKACRAPGSYGRGTHCHYKAPTVVLHMTKTD 582

  Fly   614 P 614
            |
Human   583 P 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 32/169 (19%)
7tmF_SMO_homolog 245..568 CDD:320158 86/333 (26%)
TM helix 1 254..279 CDD:320158 7/27 (26%)
TM helix 2 289..310 CDD:320158 2/20 (10%)
TM helix 3 340..366 CDD:320158 11/25 (44%)
TM helix 4 382..398 CDD:320158 9/15 (60%)
TM helix 5 420..449 CDD:320158 9/28 (32%)
TM helix 6 471..498 CDD:320158 8/26 (31%)
TM helix 7 529..554 CDD:320158 6/24 (25%)
FZD9NP_003499.1 CRD_FZ 35..161 CDD:470581 26/148 (18%)
Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 58..172 23/115 (20%)
7tmF_FZD9 221..542 CDD:320164 86/330 (26%)
TM helix 1 230..255 CDD:320164 7/24 (29%)
TM helix 2 264..285 CDD:320164 2/20 (10%)
TM helix 3 314..340 CDD:320164 11/25 (44%)
TM helix 4 357..373 CDD:320164 9/15 (60%)
TM helix 5 395..425 CDD:320164 9/29 (31%)
TM helix 6 444..471 CDD:320164 8/26 (31%)
TM helix 7 503..528 CDD:320164 6/24 (25%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 532..537 0/4 (0%)
Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 554..591 6/30 (20%)

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