DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and FZD7

DIOPT Version :10

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_003498.1 Gene:FZD7 / 8324 HGNCID:4045 Length:574 Species:Homo sapiens


Alignment Length:624 Identity:151/624 - (24%)
Similarity:250/624 - (40%) Gaps:150/624 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LCLWVVADASASSAKFGSTTPASAQQSDVELEPINGTLNYRLYAKKGRDDKPWFDGLDSRHIQCV 85
            ||..|:|...|.||..|:             :|.:|        :||              |...
Human    15 LCALVLALLGALSAGAGA-------------QPYHG--------EKG--------------ISVP 44

  Fly    86 RRARCYPTSNATNTCFGSKLPYELSSLDLTDFHTEKE-LNDKLNDYYALKHVPKCWAAIQPFLCA 149
            ....|.|.|....|    .:.|..:.|.....||.:| ...:::.:|.|..| :|...::.|||:
Human    45 DHGFCQPISIPLCT----DIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKV-QCSPELRFFLCS 104

  Fly   150 VFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFF--PKFLRCNETLFPT----------K 202
            ::.|.|..:   |....|...:|....:.|..|.|...|  |:.|||..  ||.          .
Human   105 MYAPVCTVL---DQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCEN--FPVHGAGEICVGQN 164

  Fly   203 CTNGARGMKFNGTGQCLSPLVPTDTSASYYPGI------------------------------EG 237
            .::|:.|.....|....:|.:|.....:..||.                              ..
Human   165 TSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERD 229

  Fly   238 CGVRCKDP------LYTDDEHRQIHKLIGWAG---SICLLSNLFVVSTFFIDWKNANKYPAVIVF 293
            ||..| :|      :|..:|.|:..:|  |.|   .:|..|.||.|.|:.:|.:..: ||...:.
Human   230 CGAPC-EPGRANGLMYFKEEERRFARL--WVGVWSVLCCASTLFTVLTYLVDMRRFS-YPERPII 290

  Fly   294 YINLCFLIACV----GWLLQFTSGSREDIVC----RKDGTLRHSEPTAGENLSCIVIFVLVYYFL 350
            :::.|:.:..|    |:||:      :..||    ..||....::.|..|  .|.::|:::|:|.
Human   291 FLSGCYFMVAVAHVAGFLLE------DRAVCVERFSDDGYRTVAQGTKKE--GCTILFMVLYFFG 347

  Fly   351 TAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGI 412
            .|..:|:|.|:..|...|   .||  :.|:....||||.||::|.|.|||.:|..:|||:.:.|:
Human   348 MASSIWWVILSLTWFLAAGMKWGH--EAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGV 410

  Fly   413 CFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFG----LKHFANDIKSTSASNKIHLIIM 473
            |:||..:.....|.:|.||...:.||..|:..|.|.||.    :||      ..:.:.|:..:::
Human   411 CYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH------DGTKTEKLEKLMV 469

  Fly   474 RMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFII--CKISSV------FEEKSSCRIENR 530
            |:||.::|..|...:.:||:..|....:.|.   |.:::  ||..:|      |...|       
Human   470 RIGVFSVLYTVPATIVLACYFYEQAFREHWE---RTWLLQTCKSYAVPCPPGHFPPMS------- 524

  Fly   531 PSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRK 569
            |...|..:..|.....||....|.|:..::::|:|:..:
Human   525 PDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHR 563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 34/147 (23%)
7tmF_SMO_homolog 245..568 CDD:320158 97/354 (27%)
TM helix 1 254..279 CDD:320158 9/27 (33%)
TM helix 2 289..310 CDD:320158 5/24 (21%)
TM helix 3 340..366 CDD:320158 8/25 (32%)
TM helix 4 382..398 CDD:320158 10/15 (67%)
TM helix 5 420..449 CDD:320158 9/28 (32%)
TM helix 6 471..498 CDD:320158 8/26 (31%)
TM helix 7 529..554 CDD:320158 5/24 (21%)
FZD7NP_003498.1 CRD_FZ7 45..169 CDD:143575 31/133 (23%)
7tmF_FZD7 243..573 CDD:320374 96/350 (27%)
TM helix 1 252..277 CDD:320374 9/26 (35%)
TM helix 2 286..307 CDD:320374 2/20 (10%)
TM helix 3 337..363 CDD:320374 8/25 (32%)
TM helix 4 380..396 CDD:320374 10/15 (67%)
TM helix 5 418..447 CDD:320374 9/28 (32%)
TM helix 6 467..494 CDD:320374 8/26 (31%)
TM helix 7 523..548 CDD:320374 6/31 (19%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 552..557 0/4 (0%)
PDZ-binding 572..574
Blue background indicates that the domain is not in the aligned region.

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