DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and FZD6

DIOPT Version :9

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_001158087.1 Gene:FZD6 / 8323 HGNCID:4044 Length:706 Species:Homo sapiens


Alignment Length:701 Identity:156/701 - (22%)
Similarity:269/701 - (38%) Gaps:167/701 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 KCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPCRILYNT--TFFPKFLRCN---- 195
            :|...|:.|||..|.|.| |:|:    |..|..::|......|:.|.:|  ..:|:.|.|:    
Human    68 ECSPNIETFLCKAFVPTCIEQIH----VVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQY 128

  Fly   196 -------------ETLFPTK------------C-----TNGARGMKFNGTGQCLSPLVPTDTSAS 230
                         |.|.|.|            |     |:|.:|.||.|..||..|         
Human   129 CDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCAPP--------- 184

  Fly   231 YYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYI 295
                       |.:..:..||.......||.....||.:.||...||.||.:.. :||...:.|.
Human   185 -----------CPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRF-RYPERPIIYY 237

  Fly   296 NLCFLIACVGWLLQFTSGSREDIVCRK-DGTLRHSEPT--AGENLSCIVIFVLVYYFLTAGMVWF 357
            ::|:.|..:.:.:.|..|  :...|.| |..|...:..  ..:|.:|.|:|:|:|:|..||.||:
Human   238 SVCYSIVSLMYFIGFLLG--DSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWW 300

  Fly   358 VFLTYAW------HWRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVG 416
            |.||..|      .|..     :.|::|..:||.|||..|..||:..:|.::|:|::|.|:||||
Human   301 VILTITWFLAAGRKWSC-----EAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVG 360

  Fly   417 YINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSAS-NKIHLIIMRMGVCAL 480
            ..:.......:|.|||..:.:|...:..|::   .|.|....|:....: .|:...::|:||.:.
Human   361 LYDLDASRYFVLLPLCLCVFVGLSLLLAGII---SLNHVRQVIQHDGRNQEKLKKFMIRIGVFSG 422

  Fly   481 LTLVFILVAIACHVTEFRHADEW-----AQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQLHL 540
            |.||.::..:.|:|.|..:...|     :...||:   .|...::.|:..    ||.:.:..:..
Human   423 LYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQY---HIPCPYQAKAKA----RPELALFMIKY 480

  Fly   541 LCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSI 605
            |.....||....|..:..:...|..:.::...::.:.|    ..:|:.::.    :|..|....:
Human   481 LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISE----SRRVLQESC----EFFLKHNSKV 537

  Fly   606 TLYNTHTDPVGLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPRKNSLDS 670
            .....|..|          :|.:...||.:               .|.:||.:::||      .|
Human   538 KHKKKHYKP----------SSHKLKVISKS---------------MGTSTGATANHG------TS 571

  Fly   671 EISVSVRHVSVESRRNSVDSQVSVKIAEMKTKVASRSR--------------------------- 708
            .::::......:.....:.:.....:.|:|...||..|                           
Human   572 AVAITSHDYLGQETLTEIQTSPETSMREVKADGASTPRLREQDCGEPASPAASISRLSGEQVDGK 636

  Fly   709 GKHGGSSSNRRTQRR----RDYIAAATGKSSRRRESSTSVESQVIALKKTT 755
            |:.|..|.:.|::.|    .|.......:|:..:..|:|..|   :||.:|
Human   637 GQAGSVSESARSEGRISPKSDITDTGLAQSNNLQVPSSSEPS---SLKGST 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 32/119 (27%)
Frizzled 246..568 CDD:279827 89/336 (26%)
FZD6NP_001158087.1 CRD_FZ6 20..146 CDD:143559 21/81 (26%)
Frizzled 189..507 CDD:279827 89/335 (27%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 498..503 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..706 18/100 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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