| Sequence 1: | NP_523443.1 | Gene: | smo / 33196 | FlyBaseID: | FBgn0003444 | Length: | 1036 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_036325.2 | Gene: | FZD4 / 8322 | HGNCID: | 4042 | Length: | 537 | Species: | Homo sapiens |
| Alignment Length: | 547 | Identity: | 152/547 - (27%) |
|---|---|---|---|
| Similarity: | 247/547 - (45%) | Gaps: | 104/547 - (19%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 89 RCYP--TSNATNTCFG-SKLP----YEL---SSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAI 143
Fly 144 QPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPCR-ILYNTTF-FPKFLRCNETLFPTKCTN 205
Fly 206 GARGMKFNGTGQ------CLSPLVPTD------TSASYYPGIE---GCGVRC--KDPLYTDD--E 251
Fly 252 HRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSRE 316
Fly 317 DIVCRKDGTLRHSEPT----AGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQD 374
Fly 375 RIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGG 439
Fly 440 YFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWA 504
Fly 505 QSFRQFIICKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSS---GIVMSTWCWTPSSIETWKRY 566
Fly 567 IRKKCGKEVVEEVKMPKHKVIAQTWAK 593 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| smo | NP_523443.1 | CRD_SMO | 86..221 | CDD:143560 | 42/150 (28%) |
| Frizzled | 246..568 | CDD:279827 | 97/333 (29%) | ||
| FZD4 | NP_036325.2 | CRD_FZ4 | 42..167 | CDD:143557 | 42/143 (29%) |
| 7tmF_FZD4 | 209..509 | CDD:320166 | 99/339 (29%) | ||
| TM helix 1 | 218..243 | CDD:320166 | 10/26 (38%) | ||
| TM helix 2 | 252..273 | CDD:320166 | 2/20 (10%) | ||
| TM helix 3 | 303..329 | CDD:320166 | 11/25 (44%) | ||
| TM helix 4 | 346..362 | CDD:320166 | 9/15 (60%) | ||
| TM helix 5 | 384..413 | CDD:320166 | 9/28 (32%) | ||
| TM helix 6 | 433..460 | CDD:320166 | 8/29 (28%) | ||
| TM helix 7 | 470..495 | CDD:320166 | 7/35 (20%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 499..504 | 0/4 (0%) | |||
| PDZ-binding | 535..537 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D509772at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.820 | |||||