Protein Alignment smo and FZD1

DIOPT Version :9

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_003496.1
• Gene: FZD1 / 8321
• HGNCID: 4038
• Length: 647
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 152/650 - (23%)
• Similarity: 249/650 - (38%)
• Gaps: 144/650 - (22%)

  Fly    12 IMMFLEVAILCLWVVADASASSAKFG------STTPASAQQSDVELEPINGTLNYRLYAKKGRDD 70
            ::::|..|.|.|.|.|.|:......|      ...|...|||.   :..||
Human    57 LLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSG---QQYNG-------------- 104

  Fly    71 KPWFDGLDSRHIQCVRRARCYPTS--NATNTCFGSKLPYELSSLDLTDFHTEKE-LNDKLNDYYA 132
                    .|.|.......|.|.|  ..|:..:...:...|..      ||.:| ...:::.:|.
Human   105 --------ERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLG------HTNQEDAGLEVHQFYP 155

  Fly   133 LKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFF--PKFLRCN 195
            |..| :|.|.::.|||:::.|.|..:   :....|...:|....:.|..|.|...|  |..|:|.
Human   156 LVKV-QCSAELKFFLCSMYAPVCTVL---EQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCE 216

  Fly   196 E-----------------------TLFPTKCTN--------------GARGMKFNGTGQCLSPLV 223
            :                       :|.|...|:              |..|....|...|...|.
Human   217 KFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALK 281

  Fly   224 PTDTSASYYPGIEGCGVRCKDP------LYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWK 282
            .......::.|.:.||..|:..      .:..:|.|.....||....:|..|.||.|.|:.:|.:
Human   282 VPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMR 346

  Fly   283 NANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCR----KDGTLRHSEPTAGENLSCIVIF 343
            ..: ||...:.:::.|:....|.::..|....|  :||.    :||....::.|..|  .|.::|
Human   347 RFS-YPERPIIFLSGCYTAVAVAYIAGFLLEDR--VVCNDKFAEDGARTVAQGTKKE--GCTILF 406

  Fly   344 VLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVD 405
            :::|:|..|..:|:|.|:..|...|   .||  :.|:....||||.||::|.:.|||.:|..:||
Human   407 MMLYFFSMASSIWWVILSLTWFLAAGMKWGH--EAIEANSQYFHLAAWAVPAIKTITILALGQVD 469

  Fly   406 GNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFG----LKHFANDIKSTSASN 466
            |:.:.|:||||..|.....|.:|.||...:.||..|:..|.|.||.    :||      ..:.:.
Human   470 GDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH------DGTKTE 528

  Fly   467 KIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEW-----AQSFRQFIICKISSVFEEKSSC- 525
            |:..:::|:||.::|..|...:.|||:..|....|:|     |||.:.:.|           .|
Human   529 KLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAI-----------PCP 582

  Fly   526 ----------RIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRK----KCGKEVV 576
                      .....|...|..:..|.....||....|.|:..::.:|:::..:    |.|:..|
Human   583 HLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	34/176 (19%)
		Frizzled	246..568	CDD:279827	94/348 (27%)
FZD1	NP_003496.1	CRD_FZ1	112..238	CDD:143574	27/135 (20%)
		Frizzled	310..634	CDD:279827	94/347 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810