DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smo and FZD3

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_059108.1	Gene:	FZD3 / 7976	HGNCID:	4041	Length:	666	Species:	Homo sapiens

Alignment Length:	761	Identity:	164/761 - (21%)
Similarity:	286/761 - (37%)	Gaps:	194/761 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 NTCFGSKL----PYELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKI 158
            ||.|...|    ..:.::|.:..||....|:              |....:|||||::.|.|.:.
Human    42 NTTFMPNLLNHYDQQTAALAMEPFHPMVNLD--------------CSRDFRPFLCALYAPICMEY 92

  Fly   159 NGEDMVYLPSYEMCRITMEPCRILYNT--TFFPKFLRCNETLFPTKCTNGARGMKFNGTGQCLSP 221
            .   .|.||...:|:.....|..|...  ..:|:.:.|:.  ||.......|.:..|..|:
Human    93 G---RVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSR--FPDCDEPYPRLVDLNLAGE---- 148

  Fly   222 LVPT---------------------DTSASY-YPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGS 264
              ||                     |....| :..:..|...|.:..:..:|.......||....
Human   149 --PTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFARYFIGLISI 211

  Fly   265 ICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCF----LIACVGWLLQFTSGSREDIVCRKDGT 325
            |||.:.||...||.|| ....:||...:.:..:|:    ||..:|:||:      :.:.|.....
Human   212 ICLSATLFTFLTFLID-VTRFRYPERPIIFYAVCYMMVSLIFFIGFLLE------DRVACNASIP 269

  Fly   326 LRHSEPT---AGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRAM---GHVQDRIDKKGSYFH 384
            .::...|   ...|.:|.::|:::|:|..||.||:|.||..|...|:   |  .:.|:||...||
Human   270 AQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPKWG--SEAIEKKALLFH 332

  Fly   385 LVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVML 449
            ..||.:|..|||..:|.::::|::|.|:||||..:.......:|.|||..:::|...:..|::.|
Human   333 ASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISL 397

  Fly   450 FGLKHFANDIK-----STSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQ 509
                   |.::     .....:|:...::|:||.::|.||.:||.|.|:..|..:...|..::.|
Human   398 -------NRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQ 455

  Fly   510 FIICKISSVFEEKSSCRIE----NRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKK 570
             ..|:     |....|..:    :||.:.:..:..|.....||....|..:..:...|..:...:
Human   456 -ERCR-----EYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGR 514

  Fly   571 CGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSITLYNTHTDPVGLNFDVNDLNSSETNDISST 635
            ..||:|.|    ..:|:.:.                                |...|...|.::
Human   515 RKKEIVNE----SRQVLQEP--------------------------------DFAQSLLRDPNT- 542

  Fly   636 WAAYLPQCVKRRMALTGAATGNSSSHGPRKNSLDSEISVSVRHVSVESRRNSVDSQVSVKIAEMK 700
                 |...|.|    |.:|..:|:|           :.|.:...|:.:|:        |...:.
Human   543 -----PIIRKSR----GTSTQGTSTH-----------ASSTQLAMVDDQRS--------KAGSIH 579

  Fly   701 TKVAS------RSRGKHGGSSSNRRTQRRRDYIAAATGKSSRRRESSTSVESQVIALKKTTYPNA 759
            :||:|      |||.......|.|..:.|..:     |..||..:.|..              ::
Human   580 SKVSSYHGSLHRSRDGRYTPCSYRGMEERLPH-----GSMSRLTDHSRH--------------SS 625

  Fly   760 SHKVGVFAHHSSKK--QHNYTSSMKRRTANAGLDPSILNEFLQKNG 803
            ||::...:.|||.:  .:|..:.:...|:        :|..::::|
Human   626 SHRLNEQSRHSSIRDLSNNPMTHITHGTS--------MNRVIEEDG 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	29/128 (23%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	88/340 (26%)
FZD3	NP_059108.1	CRD_FZ3	24..150	CDD:143558	29/132 (22%)
		7tmF_FZD3	192..512	CDD:320161	88/341 (26%)
		TM helix 1	201..226	CDD:320161	9/24 (38%)
		TM helix 2	235..256	CDD:320161	3/20 (15%)
		TM helix 3	287..313	CDD:320161	11/25 (44%)
		TM helix 4	330..352	CDD:320161	9/21 (43%)
		TM helix 5	366..391	CDD:320161	5/24 (21%)
		TM helix 6	419..444	CDD:320161	11/24 (46%)
		TM helix 7	473..498	CDD:320161	5/24 (21%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	502..507		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..666		34/182 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810