| Sequence 1: | NP_523443.1 | Gene: | smo / 33196 | FlyBaseID: | FBgn0003444 | Length: | 1036 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_003459.2 | Gene: | FZD5 / 7855 | HGNCID: | 4043 | Length: | 585 | Species: | Homo sapiens |
| Alignment Length: | 529 | Identity: | 138/529 - (26%) |
|---|---|---|---|
| Similarity: | 234/529 - (44%) | Gaps: | 88/529 - (16%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 100 CFGSKLPYELSSLDLTDFH-TEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDM 163
Fly 164 VYLPSYEMCRITMEPCR------------ILYNTTF-FPKFLRCN---------ETL-------- 198
Fly 199 --------FPTKCT-NGARGMKFNG---------TGQCLSPLVP-TDTSASYYPGIE-----GCG 239
Fly 240 VRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACV 304
Fly 305 GWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA- 368
Fly 369 MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCG 433
Fly 434 VILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFR 498
Fly 499 HADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQL-HLLCLFSSGIVMSTWCWTPSSIET 562
Fly 563 WKRYIRKKC 571 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| smo | NP_523443.1 | CRD_SMO | 86..221 | CDD:143560 | 33/169 (20%) |
| Frizzled | 246..568 | CDD:279827 | 95/323 (29%) | ||
| FZD5 | NP_003459.2 | TM helix 5 | 397..426 | CDD:320377 | 10/28 (36%) |
| TM helix 6 | 446..473 | CDD:320377 | 8/26 (31%) | ||
| TM helix 7 | 496..521 | CDD:320377 | 8/31 (26%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 525..530 | 1/4 (25%) | |||
| PDZ-binding | 583..585 | ||||
| CRD_FZ5 | 29..156 | CDD:143569 | 25/130 (19%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 156..179 | 6/22 (27%) | |||
| 7tmF_FZD5 | 225..535 | CDD:320377 | 96/324 (30%) | ||
| TM helix 1 | 234..259 | CDD:320377 | 7/24 (29%) | ||
| TM helix 2 | 268..289 | CDD:320377 | 4/20 (20%) | ||
| TM helix 3 | 316..342 | CDD:320377 | 10/25 (40%) | ||
| TM helix 4 | 359..375 | CDD:320377 | 9/15 (60%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D509772at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.820 | |||||