DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smo and SMO

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_005622.1	Gene:	SMO / 6608	HGNCID:	11119	Length:	787	Species:	Homo sapiens

Alignment Length:	739	Identity:	275/739 - (37%)
Similarity:	420/739 - (56%)	Gaps:	90/739 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PRMPNIMMFLEVAILCLWVVADASASSAKFGSTT---PASAQQSDVELEPING---TLNYRLYAK 65
            |.:|.:      .:|.|.::.|....:|..|:.|   |.||..|......:.|   .|::
Human    10 PELPLL------GLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSH----- 63

  Fly    66 KGRDDKPWFDGLDSRHIQCVRRARCYPTSNATNTCFGSKLPYELSSLDLT-DFHTEKELNDKLND 129
                              |.|.|.|.|.  ..|.|.||.|||..:|..|. |..:::|.:.||..
Human    64 ------------------CGRAAPCEPL--RYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVL 108

  Fly   130 YYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFFPKFLRC 194
            :..|::.|:|||.|||.||||:.||||    .|.|.|||..:|:.|..||.|:.....:|.||||
Human   109 WSGLRNAPRCWAVIQPLLCAVYMPKCE----NDRVELPSRTLCQATRGPCAIVERERGWPDFLRC 169

  Fly   195 NETLFPTKCTNGARGMKFNGTGQCLSPLVPTDTSASYYPGIEGCGVRCKDPLYTDDEHRQIHKLI 259
            ....||..|||..:.:|||.:|||..|||.||...|:|..:||||::|::||:|:.||:.:|..|
Human   170 TPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYI 234

  Fly   260 GWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDG 324
            ...|::..|..||.::||..||:|:|:|||||:||:|.||.:..:|||.||..|:|.:||||.||
Human   235 AAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADG 299

  Fly   325 TLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWH--WRAMGHVQDRIDKKGSYFHLVA 387
            |:|..|||:.|.|||::|||:|||.|.||:||||.||||||  ::|:|.....:..|.|||||:.
Human   300 TMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLT 364

  Fly   388 WSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGL 452
            ||||.|||:..:|.::|||:|:.|||||||.|:..|||.:|.|:..|:::||||:.||::.||.:
Human   365 WSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSI 429

  Fly   453 KHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISS 517
            |.....:.|..|::||:..::|:|:...|...|:|:..:||..:|.:..||.:|||.:::|:.:.
Human   430 KSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANV 494

  Fly   518 VF-----EEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVE 577
            ..     :....|.|:||||:.|.:::|..:|.:||.||||.||.:::..|:|...:..|:...|
Human   495 TIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDE 559

  Fly   578 EVKMPKHKVIAQTWAKRKD-FEDKGR-LSITLYN-THTDPV-GLNFDVNDLNSSETNDISSTWAA 638
            ..::.|.|:||:.::||.: .::.|: ||.:::. :|..|| ||.||:|:.::    |:||.||.
Human   560 PKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSA----DVSSAWAQ 620

  Fly   639 YLPQCVKRRMALTGAATGNSSSHGPRKNSLDSEISVS--VRHVSVESRRN--SVDSQVSVKIAEM 699
            ::.:.|.||.|:                 |..:|||:  ...|..|.:.|  .|::::|.::.
Human   621 HVTKMVARRGAI-----------------LPQDISVTPVATPVPPEEQANLWLVEAEISPELQ-- 666

  Fly   700 KTKVASRSRGKHGGSSSNRRTQRR 723
                      |..|....||.:::
Human   667 ----------KRLGRKKKRRKRKK 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	59/135 (44%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	147/328 (45%)
SMO	NP_005622.1	CRD_SMO	66..196	CDD:143560	59/135 (44%)
SMO	NP_005622.1	Frizzled	221..550	CDD:279827	147/328 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154104
Domainoid	1	1.000	329	1.000	Domainoid score	I1161
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4115
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1376
Isobase	1	0.950	-	0	Normalized mean entropy	S5764
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114070at33208
OrthoFinder	1	1.000	-	-		FOG0008402
OrthoInspector	1	1.000	-	-		oto88890
orthoMCL	1	0.900	-	-		OOG6_108731
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4761
SonicParanoid	1	1.000	-	-		X6393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740