DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smo and Fzd4

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_072145.1	Gene:	Fzd4 / 64558	RGDID:	71017	Length:	538	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	156/562 - (27%)
Similarity:	251/562 - (44%)	Gaps:	112/562 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 FDGLDSRHIQCVRRARCYPTS-NATNTCFGSKLP----YEL---SSLDLTDFHTEKELNDKLNDY 130
            |...:.|....:|.|.|.... |.|      |:|    :||   :.|.||.|       ..|..|
  Rat    38 FGDEEERRCDPIRIAMCQNLGYNVT------KMPNLVGHELQTDAELQLTTF-------TPLIQY 89

  Fly   131 YALKHVPKCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPCR-ILYNTTF-FPKFL 192
                   .|.:.:|.|||:|:.|.| ||||   :...|...||......|. :|....| :|..|
  Rat    90 -------GCSSQLQFFLCSVYVPMCTEKIN---IPIGPCGGMCLSVKRRCEPVLKEFGFAWPDSL 144

  Fly   193 RCNETLFPTKCTNGARGMKFNGTGQ------CLSPLVPTD------TSASYYPGIE---GCGVRC 242
            .|::  ||.:  |....|...|.|.      ..:|:.|.:      |::..|..::   .|.::|
  Rat   145 NCSK--FPPQ--NDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKC 205

  Fly   243 --KDPLYTDD--EHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIAC 303
              ...||:..  |...|...: || |:|.:|..|.|.||.|| .:...||...:.::::|:.|..
  Rat   206 GYDAGLYSRSAKEFTDIWMAV-WA-SLCFISTTFTVLTFLID-SSRFSYPERPIIFLSMCYNIYS 267

  Fly   304 VGWLLQFTSGSREDIVCRKDGTLRHSEPT----AGENLSCIVIFVLVYYFLTAGMVWFVFLTYAW 364
            :.::::.|.| ||.|.|..:   ..:||.    ..:|..|.:||:|:|:|..|..:|:|.||..|
  Rat   268 IAYIVRLTVG-RERISCDFE---EAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTW 328

  Fly   365 HWRA---MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRA-- 424
            ...|   .||  :.|:...||||:.||::|.|.||..:....||.:.:.|:|:||  |.|:.|
  Rat   329 FLAAGLKWGH--EAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVG--NQSLDALT 389

  Fly   425 GLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVA 489
            |.::.||...::||..||..|:|.||.::  :|..|..:.::|:..:::::||.::|..|.....
  Rat   390 GFVVAPLFTYLVIGTLFIAAGLVALFKIR--SNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCV 452

  Fly   490 IACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSS---GIVMS 551
            |||:   |.....||       :.:.|:   :.|:..:|           :|.:|.|   ||...
  Rat   453 IACY---FYEISNWA-------LFRYSA---DDSNMAVE-----------MLKIFMSLLVGITSG 493

  Fly   552 TWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAK 593
            .|.|:..::.||     :||...:|...|:.:.| ....|.|
  Rat   494 MWIWSAKTLHTW-----QKCSNRLVNSGKVKREK-RGNGWVK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	42/151 (28%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	99/335 (30%)
Fzd4	NP_072145.1	CRD_FZ4	43..168	CDD:143557	43/151 (28%)
		Frizzled	211..510	CDD:279827	101/340 (30%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	500..505		0/4 (0%)
		PDZ-binding	536..538
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820