Protein Alignment smo and Fzd1

DIOPT Version :9

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_067089.2
• Gene: Fzd1 / 58868
• RGDID: 61916
• Length: 642
• Species: Rattus norvegicus
• Alignment Length: 645
• Identity: 155/645 - (24%)
• Similarity: 256/645 - (39%)
• Gaps: 138/645 - (21%)

  Fly    12 IMMFLEVAILCLWVVADASASSAKFGSTTPASAQQSDVELEPINGTLNYRLYAKKGRDDKPWFDG 76
            ::::|..|.|.|.|.|.|:...:..|...|...|       |..|...|.
  Rat    56 LLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQ-------PQQGGQQYN--------------- 98

  Fly    77 LDSRHIQCVRRARCYPTS--NATNTCFGSKLPYELSSLDLTDFHTEKE-LNDKLNDYYALKHVPK 138
             ..|.|.......|.|.|  ..|:..:...:...|..      ||.:| ...:::.:|.|..| :
  Rat    99 -GERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLG------HTNQEDAGLEVHQFYPLVKV-Q 155

  Fly   139 CWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFF--PKFLRCNE----- 196
            |.|.::.|||:::.|.|..:   :....|...:|....:.|..|.|...|  |..|:|.:
  Rat   156 CSAELKFFLCSMYAPVCTVL---EQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHG 217

  Fly   197 ------------------TLFPTKCTN-------GARGMKFNGTG-------QCLSPL-VPTDTS 228
                              :|.|...|:       |.||....|.|       .|...| ||:..:
  Rat   218 AGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALRVPSYLN 282

  Fly   229 ASYYPGIEGCGVRCKDP------LYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKY 287
             .::.|.:.||..|:..      .:..:|.|.....||....:|..|.||.|.|:.:|.:..: |
  Rat   283 -YHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFS-Y 345

  Fly   288 PAVIVFYINLCFLIACVGWLLQFTSGSREDIVCR----KDGTLRHSEPTAGENLSCIVIFVLVYY 348
            |...:.:::.|:....|.::..|....|  :||.    :||....::.|..|  .|.::|:::|:
  Rat   346 PERPIIFLSGCYTAVAVAYIAGFLLEDR--VVCNDKFAEDGARTVAQGTKKE--GCTILFMMLYF 406

  Fly   349 FLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIV 410
            |..|..:|:|.|:..|...|   .||  :.|:....||||.||::|.:.|||.:|..:|||:.:.
  Rat   407 FSMASSIWWVILSLTWFLAAGMKWGH--EAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLS 469

  Fly   411 GICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFG----LKHFANDIKSTSASNKIHLI 471
            |:||||..|.....|.:|.||...:.||..|:..|.|.||.    :||      ..:.:.|:..:
  Rat   470 GVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH------DGTKTEKLEKL 528

  Fly   472 IMRMGVCALLTLVFILVAIACHVTEFRHADEW-----AQSFRQFII-CKISSVFEEKSSCRIEN- 529
            ::|:||.::|..|...:.|||:..|....|:|     |||.:.:.| |.           .::.
  Rat   529 MVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCP-----------HLQGG 582

  Fly   530 ---------RPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRK----KCGKEVV 576
                     .|...|..:..|.....||....|.|:..::.:|:::..:    |.|:..|
  Rat   583 GGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	36/176 (20%)
		Frizzled	246..568	CDD:279827	94/348 (27%)
Fzd1	NP_067089.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..99		6/47 (13%)
		CRD_FZ1	107..233	CDD:143574	27/135 (20%)
		Frizzled	305..629	CDD:279827	94/347 (27%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	620..625		0/4 (0%)
		PDZ-binding	640..642		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810