DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and fzd8a

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_570993.2	Gene:	fzd8a / 58073	ZFINID:	ZDB-GENE-000328-3	Length:	579	Species:	Danio rerio

Alignment Length:	521	Identity:	129/521 - (24%)
Similarity:	226/521 - (43%)	Gaps:	104/521 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 TEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCR--- 180
            |:.|...:::.::.|..: :|...::.|||:::.|.|          |..|:.   .:.|||
Zfish    56 TQDEAGLEVHQFWPLVEI-QCSPDLKFFLCSMYTPIC----------LEDYKK---PLPPCRSVC 106

  Fly   181 ---------ILYNTTF-FPKFLRCN--------ETL---------------------FPTKCTN- 205
                     ::....| :|..:||:        :||                     :|:|..|
Zfish   107 ERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGAPDTLCMDYNRTDSTTVSPVLSKPTNYPSKAINP 171

  Fly   206 -----GARGMKFNGTG------QCLSPLVPTDTSASYYP--------GIEGCGVRCKDPLYTDDE 251
                 |..|:..|...      ||.:|:||.::..  :|        .|..|.:.|.:|.:|.||
Zfish   172 HKKKSGRPGVGPNKNKPCEPGCQCRAPMVPVNSDR--HPLYNRVKTGQIPNCAMPCHNPYFTQDE 234

  Fly   252 HRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSRE 316
            .......||....:|.:|....|:||.||.:.. |||...:.:::.|::...:|::::..:| .|
Zfish   235 RTFTAFWIGLWSVLCFISTFATVATFLIDMERF-KYPERPIIFLSACYMFVSIGYIVRLIAG-HE 297

  Fly   317 DIVCRKDGTLRHSE-PTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA-MGHVQDRIDKK 379
            .:.|.::..:.|.. .|.|..| |.|:|:|:|:|..|..:|:|.|:..|...| |....:.|...
Zfish   298 KVACNREYDVEHIHYETTGPAL-CTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGY 361

  Fly   380 GSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITR 444
            ..||||.||.:|.:.:|..:|.|.|||:.:.|||:||..|.....|.:|.||...:.||..|:..
Zfish   362 SQYFHLAAWLIPSMKSIAVLALSSVDGDPVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLA 426

  Fly   445 GMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQ 509
            |.|.||.::....  :..:.::|:..:::|:|:..:|..|...:.:||:..|..:...|.
Zfish   427 GFVSLFRIRSVIK--QGGTKTDKLEKLMIRIGIFTVLYTVPATIIVACYFYEQHNRQSWE----- 484

  Fly   510 FIICKISSVFEEKSSCRIE---NRPSVGVLQL-HLLCLFSSGIVMSTWCWTPSSIETWKRYIRKK 570
                     .....||.:|   .||...|..| :.:||. .||....|.|:..::|:|:.:..:.
Zfish   485 ---------ITHNCSCLLEQEIKRPDYAVFMLKYFMCLL-VGITSGVWTWSGKTLESWRSFCTRC 539

  Fly   571 C 571
            |
Zfish   540 C 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	28/155 (18%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	92/327 (28%)
fzd8a	NP_570993.2	CRD_FZ8	26..150	CDD:143570	20/107 (19%)
		7tmF_FZD8	228..537	CDD:320378	93/328 (28%)
		TM helix 1	237..262	CDD:320378	7/24 (29%)
		TM helix 2	271..292	CDD:320378	2/20 (10%)
		TM helix 3	321..343	CDD:320378	9/21 (43%)
		TM helix 4	364..380	CDD:320378	8/15 (53%)
		TM helix 5	402..425	CDD:320378	7/22 (32%)
		TM helix 6	453..478	CDD:320378	7/24 (29%)
		TM helix 7	498..523	CDD:320378	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820