Protein Alignment smo and fzd8a

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_570993.2
• Gene: fzd8a / 58073
• ZFINID: ZDB-GENE-000328-3
• Length: 579
• Species: Danio rerio
• Alignment Length: 521
• Identity: 129/521 - (24%)
• Similarity: 226/521 - (43%)
• Gaps: 104/521 - (19%)

  Fly   119 TEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCR--- 180
            |:.|...:::.::.|..: :|...::.|||:::.|.|          |..|:.   .:.|||
Zfish    56 TQDEAGLEVHQFWPLVEI-QCSPDLKFFLCSMYTPIC----------LEDYKK---PLPPCRSVC 106

  Fly   181 ---------ILYNTTF-FPKFLRCN--------ETL---------------------FPTKCTN- 205
                     ::....| :|..:||:        :||                     :|:|..|
Zfish   107 ERAKAGCAPLMRQYGFPWPDRMRCDLLPVQGAPDTLCMDYNRTDSTTVSPVLSKPTNYPSKAINP 171

  Fly   206 -----GARGMKFNGTG------QCLSPLVPTDTSASYYP--------GIEGCGVRCKDPLYTDDE 251
                 |..|:..|...      ||.:|:||.::..  :|        .|..|.:.|.:|.:|.||
Zfish   172 HKKKSGRPGVGPNKNKPCEPGCQCRAPMVPVNSDR--HPLYNRVKTGQIPNCAMPCHNPYFTQDE 234

  Fly   252 HRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSRE 316
            .......||....:|.:|....|:||.||.:.. |||...:.:::.|::...:|::::..:| .|
Zfish   235 RTFTAFWIGLWSVLCFISTFATVATFLIDMERF-KYPERPIIFLSACYMFVSIGYIVRLIAG-HE 297

  Fly   317 DIVCRKDGTLRHSE-PTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA-MGHVQDRIDKK 379
            .:.|.::..:.|.. .|.|..| |.|:|:|:|:|..|..:|:|.|:..|...| |....:.|...
Zfish   298 KVACNREYDVEHIHYETTGPAL-CTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGY 361

  Fly   380 GSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITR 444
            ..||||.||.:|.:.:|..:|.|.|||:.:.|||:||..|.....|.:|.||...:.||..|:..
Zfish   362 SQYFHLAAWLIPSMKSIAVLALSSVDGDPVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLA 426

  Fly   445 GMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQ 509
            |.|.||.::....  :..:.::|:..:::|:|:..:|..|...:.:||:..|..:...|.
Zfish   427 GFVSLFRIRSVIK--QGGTKTDKLEKLMIRIGIFTVLYTVPATIIVACYFYEQHNRQSWE----- 484

  Fly   510 FIICKISSVFEEKSSCRIE---NRPSVGVLQL-HLLCLFSSGIVMSTWCWTPSSIETWKRYIRKK 570
                     .....||.:|   .||...|..| :.:||. .||....|.|:..::|:|:.:..:.
Zfish   485 ---------ITHNCSCLLEQEIKRPDYAVFMLKYFMCLL-VGITSGVWTWSGKTLESWRSFCTRC 539

  Fly   571 C 571
            |
Zfish   540 C 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	28/155 (18%)
		7tmF_SMO_homolog	245..568	CDD:320158	93/328 (28%)
		TM helix 1	254..279	CDD:320158	7/24 (29%)
		TM helix 2	289..310	CDD:320158	2/20 (10%)
		TM helix 3	340..366	CDD:320158	10/25 (40%)
		TM helix 4	382..398	CDD:320158	8/15 (53%)
		TM helix 5	420..449	CDD:320158	9/28 (32%)
		TM helix 6	471..498	CDD:320158	7/26 (27%)
		TM helix 7	529..554	CDD:320158	8/25 (32%)
fzd8a	NP_570993.2	CRD_FZ8	26..150	CDD:143570	20/107 (19%)
		7tmF_FZD8	228..537	CDD:320378	93/328 (28%)
		TM helix 1	237..262	CDD:320378	7/24 (29%)
		TM helix 2	271..292	CDD:320378	2/20 (10%)
		TM helix 3	321..343	CDD:320378	9/21 (43%)
		TM helix 4	364..380	CDD:320378	8/15 (53%)
		TM helix 5	402..425	CDD:320378	7/22 (32%)
		TM helix 6	453..478	CDD:320378	7/24 (29%)
		TM helix 7	498..523	CDD:320378	8/25 (32%)