DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and fzd8b

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_571628.1	Gene:	fzd8b / 58072	ZFINID:	ZDB-GENE-000328-4	Length:	576	Species:	Danio rerio

Alignment Length:	509	Identity:	125/509 - (24%)
Similarity:	227/509 - (44%)	Gaps:	90/509 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 EKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCR---- 180
            :.|...:::.::.|..: :|...::.|||:::.|.|          |..|:.   .:.|||
Zfish    58 QDEAGLEVHQFWPLVEI-QCSPDLRFFLCSMYTPIC----------LEDYKK---PLPPCRSVCE 108

  Fly   181 --------ILYNTTF-FPKFLRCNETLFPTKCTNGARGMKFNGTGQCLSPLVPTDTS-------- 228
                    ::....| :|..:||:  |.|.:.......|.:|.|....||..|..||
Zfish   109 RAKAGCAPLMRQYGFPWPDRMRCD--LLPVQGDPNTLCMDYNRTDATSSPAAPKTTSRPGKPFKR 171

  Fly   229 -------------------------ASYYP--------GIEGCGVRCKDPLYTDDEHRQIHKLIG 260
                                     :.::|        .|..|.:.|.:|..:.:|.......||
Zfish   172 KNKSSPGSSSCEPECYCRAPMVPVHSDHHPLYNRVKTGQIPNCAMPCHNPYLSQEERTFATFWIG 236

  Fly   261 WAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGT 325
            ....:|.||....|:||.||.:.. |||...:.:::.|::...:|::::..:| .|.:.|.::..
Zfish   237 IWSVLCFLSTFATVATFLIDIERF-KYPERPIIFLSACYMFVSLGYIIRLIAG-HERVACNQNHE 299

  Fly   326 LRHSE-PTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA-MGHVQDRIDKKGSYFHLVAW 388
            :.|.. .|.|..| |.::|:|:|:|..|..:|:|.|::.|...| :....:.|.:...|||:.||
Zfish   300 VDHIHYETTGPAL-CTLVFLLIYFFGMASAIWWVILSFTWFLAAGLKWGNEAIARYSQYFHMAAW 363

  Fly   389 SLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLK 453
            .:|.|.:||.:|.|.|||:||.|||:||..|.....|.:|.||...:.||..|:..|.|.:|.::
Zfish   364 LIPSVKSITVLALSSVDGDSIAGICYVGNQNLDNLRGFVLAPLVIYLFIGTIFLFAGFVSMFRIR 428

  Fly   454 HFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSV 518
            ....  :..:.::|:..:::|:||..:|..|..::.:||:|.|..:.:.|..:.    .|..||
Zfish   429 SVIK--QGGTKTDKLERLMVRIGVFTVLYTVVAIMIVACYVYEHHNREAWEIAH----ACNCSS- 486

  Fly   519 FEEKSSCRIENRPSVGVLQL-HLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKC 571
             ::|:.     :|...|..| :.:||. .||....|.|:..::::|:....:.|
Zfish   487 -DKKAP-----KPDYAVFMLKYFMCLL-IGITSGAWTWSSKTLDSWRALCTRCC 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	22/113 (19%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	92/324 (28%)
fzd8b	NP_571628.1	CRD_FZ8	27..151	CDD:143570	21/108 (19%)
		7tmF_FZD8	221..530	CDD:320378	93/325 (29%)
		TM helix 1	230..255	CDD:320378	8/24 (33%)
		TM helix 2	264..285	CDD:320378	2/20 (10%)
		TM helix 3	314..336	CDD:320378	8/21 (38%)
		TM helix 4	357..373	CDD:320378	8/15 (53%)
		TM helix 5	395..418	CDD:320378	7/22 (32%)
		TM helix 6	446..471	CDD:320378	9/24 (38%)
		TM helix 7	491..516	CDD:320378	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820