Protein Alignment smo and fzd9b

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_571586.1
• Gene: fzd9b / 58023
• ZFINID: ZDB-GENE-000906-4
• Length: 577
• Species: Danio rerio
• Alignment Length: 540
• Identity: 137/540 - (25%)
• Similarity: 239/540 - (44%)
• Gaps: 78/540 - (14%)

  Fly    86 RRARCYPTSNATNTCFGSKLPYELSSL-DLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCA 149
            |.|:|.|.  ....|.|  :.|.|:.: :..|...::|...|||::..|... .|...::.|||:
Zfish    33 RPAKCEPI--VIPMCQG--IGYNLTRMPNFMDHDNQREAAIKLNEFAPLVEY-GCDVHLRFFLCS 92

  Fly   150 VFKPKC-EKINGEDMVYLPSYEMCRITMEPCRILYNTTFFPKFLRC------------------N 195
            ::.|.| ::::.......|..|..|....|....:|.. :|:.|.|                  |
Zfish    93 LYAPMCTDQVSTSIPACRPMCEQARQECSPIMEKFNYA-WPESLNCSKLPTRNDPNALCMEAPEN 156

  Fly   196 ETLFPTKCTN------------GARGMKFNGT-GQCLSPLVPTDTSASYYPGIEGCGVRCK---D 244
            :|...||...            ||...:..|| |.|.:|     ....|....|.|..||.   |
Zfish   157 DTKTETKKGEGMLPVPPRPRQPGAGNARSGGTMGVCENP-----EKFQYVEKSETCAPRCSSAVD 216

  Fly   245 PLYT--DDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWL 307
            ..::  |.:...|...: |: ::|.:|..|.|.||.:| .:..:||...:.::::|:.:..|.::
Zfish   217 VFWSRQDKDFAFIWMAV-WS-TLCFVSTAFTVLTFLLD-PHRFQYPERPIIFLSMCYNVYSVAFI 278

  Fly   308 LQFTSGSREDIVC-RKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA--- 368
            ::..:|: |:|.| |::|.| :......|:..|.::|:::|||..|..:|:|.||..|...|
Zfish   279 IRSVAGA-ENIACDRENGEL-YIIQEGLESTGCTIVFLILYYFGMASSIWWVILTLTWFLAAGKK 341

  Fly   369 MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCG 433
            .||  :.|:...||||:.||.:|.:.||..:...:|.|:.:.|:|:||.::.....|.:|.||..
Zfish   342 WGH--EAIESHSSYFHMAAWGIPALKTIVILTMRKVAGDELTGLCYVGSMDVGALTGFVLVPLSC 404

  Fly   434 VILIGGYFITRGMVMLFGLKHFANDIKSTSASN--KIHLIIMRMGVCALLTLVFILVAIACHVTE 496
            .::||..||..|.|.||.::    .:..|..:|  |:..:::::|:.::|..|.....|.|:..|
Zfish   405 YLVIGTSFILTGFVALFHIR----KVMKTEGTNTEKLEKLMVKIGIYSILYTVPATCVIICYFYE 465

  Fly   497 FRHADEWAQSFRQFIICKISSVFEEKSSCRIENR-PSVGVLQLHLLCLFSSGIVMSTWCWTPSSI 560
            ..:.|.|  .||.......:........|.:::. |:|.|..|.:......||....|.|:..::
Zfish   466 RLNMDYW--KFRGLQSKCTTFPGRRNEDCSLDSSVPTVAVFILKIFMSLVVGITSGVWVWSSKTL 528

  Fly   561 ETWK---------RYIRKKC 571
            :||:         |..||.|
Zfish   529 QTWQGLCSRKLTDRTCRKHC 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	38/167 (23%)
		7tmF_SMO_homolog	245..568	CDD:320158	89/340 (26%)
		TM helix 1	254..279	CDD:320158	8/24 (33%)
		TM helix 2	289..310	CDD:320158	2/20 (10%)
		TM helix 3	340..366	CDD:320158	10/25 (40%)
		TM helix 4	382..398	CDD:320158	8/15 (53%)
		TM helix 5	420..449	CDD:320158	10/28 (36%)
		TM helix 6	471..498	CDD:320158	6/26 (23%)
		TM helix 7	529..554	CDD:320158	6/25 (24%)
fzd9b	NP_571586.1	CRD_FZ9	33..159	CDD:143572	29/131 (22%)
		7tmF_FZD9	217..536	CDD:320164	88/331 (27%)
		TM helix 1	226..251	CDD:320164	8/26 (31%)
		TM helix 2	260..281	CDD:320164	2/20 (10%)
		TM helix 3	310..336	CDD:320164	10/25 (40%)
		TM helix 4	353..369	CDD:320164	8/15 (53%)
		TM helix 5	391..421	CDD:320164	10/29 (34%)
		TM helix 6	440..467	CDD:320164	6/26 (23%)
		TM helix 7	497..522	CDD:320164	6/24 (25%)