Protein Alignment smo and Fzd2

DIOPT Version :9

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_065256.1
• Gene: Fzd2 / 57265
• MGIID: 1888513
• Length: 570
• Species: Mus musculus
• Alignment Length: 529
• Identity: 124/529 - (23%)
• Similarity: 217/529 - (41%)
• Gaps: 120/529 - (22%)

  Fly   118 HTEKE-LNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRI 181
            ||.:| ...:::.:|.|..| :|...::.|||:::.|.|..:   :....|...:|....:.|..
Mouse    68 HTNQEDAGLEVHQFYPLVKV-QCSPELRFFLCSMYAPVCTVL---EQAIPPCRSICERARQGCEA 128

  Fly   182 LYNTTFF--PKFLRCNE-------------------------TLFPTKCTNGARG---------- 209
            |.|...|  |:.|||..                         |..|:....||.|
Mouse   129 LMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPSGLQPGAGGTPGGPGGGGS 193

  Fly   210 ------------------------MKFNGTGQCLSPLVPTDTSASYYPGIEGCGVRCKDPLYTDD 250
                                    .||.|...|.:|..|.....|.:              ::.:
Mouse   194 PPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMF--------------FSQE 244

  Fly   251 EHRQIHK-LIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGS 314
            |.|.... ::.|: .:|..|..|.|:|:.:|.:.. :||...:.:::.|:.:..|.::..|.  .
Mouse   245 ETRFARLWILTWS-VLCCASTFFTVTTYLVDMQRF-RYPERPIIFLSGCYTMVSVAYIAGFV--L 305

  Fly   315 REDIVCR----KDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHV 372
            :|.:||.    :||.....:.|..|  .|.::|:::|:|..|..:|:|.|:..|...|   .||
Mouse   306 QERVVCNERFSEDGYRTVVQGTKKE--GCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGH- 367

  Fly   373 QDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILI 437
             :.|:....||||.||::|.|.|||.:|..::||:.:.|:||||..:.....|.:|.||...:.|
Mouse   368 -EAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFI 431

  Fly   438 GGYFITRGMVMLFG----LKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFR 498
            |..|:..|.|.||.    :||      ..:.:.|:..:::|:||.::|..|...:.|||:..|..
Mouse   432 GTSFLLAGFVSLFRIRTIMKH------DGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQA 490

  Fly   499 HADEWAQSF-RQFIICKISSV-----FEEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTP 557
            ..:.|.:|: .|.  ||..::     :..:.|      |...|..:..|.....||....|.|:.
Mouse   491 FREHWERSWVSQH--CKSLAIPCPAHYTPRMS------PDFTVYMIKYLMTLIVGITSGFWIWSG 547

  Fly   558 SSIETWKRY 566
            .::.:|:::
Mouse   548 KTLHSWRKF 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	31/164 (19%)
		Frizzled	246..568	CDD:279827	90/339 (27%)
Fzd2	NP_065256.1	CRD_FZ2	40..166	CDD:143573	22/101 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..194		5/27 (19%)
		Frizzled	240..557	CDD:279827	90/353 (25%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	548..553		0/4 (0%)
		PDZ-binding	568..570

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810