DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and fzd3b

DIOPT Version :9

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_001074070.1 Gene:fzd3b / 567746 ZFINID:ZDB-GENE-070122-1 Length:667 Species:Danio rerio


Alignment Length:799 Identity:179/799 - (22%)
Similarity:297/799 - (37%) Gaps:225/799 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 DKPW-----------FDGLDSRHIQCVRRARCYPTSNATNTC--FGSK----LPY---------- 107
            |.||           ..|..:.|:..|       .|::..||  .|.:    |||          
Zfish     6 DLPWRGMWILSVVSLLSGSMAIHMDSV-------GSHSLFTCESIGLRMCQDLPYNNTFMPNLLN 63

  Fly   108 ----ELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPS 168
                :.::|.:..||....|              :|...::|||||::.|.|.:..   .|.||.
Zfish    64 HYDQQTAALAMEPFHPMVNL--------------QCSPDLRPFLCALYAPVCMEYG---RVSLPC 111

  Fly   169 YEMCRITMEPCRIL---YNTTFFPKFLRCNETLFPTKCTNGARGMKFNGTGQCLSPLV---PTDT 227
            ..:|......|:.|   :..| :|:.:.|  |.||....:..|....         ||   |||.
Zfish   112 RSLCHHAKRDCQKLMDMFGVT-WPEEMEC--TRFPDCDESYPRAEDL---------LVIDDPTDQ 164

  Fly   228 S---------------------ASY-YPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSN 270
            |                     ..| :.|:..|...|.:..:..:|.......||....:||.:.
Zfish   165 SPMSVQRDYGFWCPRELKMEPDLGYTFLGVRDCSPPCPNMYFRREELTFARYFIGVVSIVCLSAT 229

  Fly   271 LFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCR--KDGTLRHSEPTA 333
            ||...||.|| ....:||...:.:..:|:::..:.:.|.|....|  :.|.  ..|..:.|..|.
Zfish   230 LFTFLTFLID-VTRFRYPERPIIFYAVCYMMVSLVFFLGFLLEDR--VACNSANPGQYKTSTVTQ 291

  Fly   334 G-ENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRAM---GHVQDRIDKKGSYFHLVAWSLPLVL 394
            | .|.:|.::|:::|:|..||.||:|.||..|...|:   |  .:.|:||...||..||.:|.:|
Zfish   292 GSHNKACTLLFMVLYFFTMAGSVWWVILTITWFLAAVPKWG--SEAIEKKALLFHASAWGIPGML 354

  Fly   395 TITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDI 459
            ||..:|.::::|::|.|:||||..:.......:|.|||..:|:|...:..|:|.|       |.:
Zfish   355 TIALLALNKIEGDNISGVCFVGVYDVQTLRWFVLAPLCLDVLVGVSLLLAGIVAL-------NRV 412

  Fly   460 K-----STSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQ------FIIC 513
            :     ......|:...::|:||.::|.||.:|..:.|::.|..:...|..::.|      .|.|
Zfish   413 RMEIPLEKENQEKLVKFMIRIGVFSVLYLVPLLTVVGCYLYEQTYRSVWETTWVQERCREYHIPC 477

  Fly   514 KISSVFEEKSSCRIE--NRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVV 576
            ..          ::|  :||.:.:..:..|.:...||....|..:..:...|..:...:      
Zfish   478 PF----------KVEQTSRPDLVLFLIKYLMVLVVGIPSVFWVGSKKTCFEWAGFFHGR------ 526

  Fly   577 EEVKMPKHKVIAQTWAKRKD----FEDKGRLSITLYNTHTDPVGLNFDVNDLNSSETNDISSTWA 637
                            :|||    .|.:..|.        ||        |...|...|.::   
Zfish   527 ----------------RRKDSGAVHESRQVLQ--------DP--------DFAQSLLRDPNT--- 556

  Fly   638 AYLPQCVKRRMALTGAATGNSSSHGPRKNSLDSEISVSVRHVS----VESRRNSVDSQVSVKIAE 698
               |...|.|    |.:|..:|:|            .|..|::    |.|:.:||.|:.|...: 
Zfish   557 ---PIVRKSR----GTSTQGTSTH------------ASSTHLAMLDDVRSKASSVHSKSSFHSS- 601

  Fly   699 MKTKVASRSRGKHGGSSSNRRTQRRRDYIAAATGKSSRRRESSTSVESQVIALKKTTYPNASHKV 763
                 ..|||.:...||::|..:.|..|     |...|..:...|        :.::.|..||..
Zfish   602 -----LQRSRDERFTSSTHRGLEERPAY-----GSLPRLTDQQPS--------RHSSTPELSHTP 648

  Fly   764 GVFAHHSSKKQ--HNYTSS 780
            .|......:::  .|.||:
Zfish   649 AVSESQQEEQEQPENGTSA 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 32/157 (20%)
Frizzled 246..568 CDD:279827 88/340 (26%)
fzd3bNP_001074070.1 CRD_FZ 36..162 CDD:382974 33/154 (21%)
7tmF_FZD3 204..524 CDD:320161 88/341 (26%)
TM helix 1 213..238 CDD:320161 8/24 (33%)
TM helix 2 247..268 CDD:320161 2/20 (10%)
TM helix 3 299..325 CDD:320161 11/25 (44%)
TM helix 4 342..364 CDD:320161 9/21 (43%)
TM helix 5 378..403 CDD:320161 6/24 (25%)
TM helix 6 431..456 CDD:320161 9/24 (38%)
TM helix 7 485..510 CDD:320161 5/24 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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