DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smo and fzd3a

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	XP_005160805.1	Gene:	fzd3a / 565921	ZFINID:	ZDB-GENE-990415-225	Length:	686	Species:	Danio rerio

Alignment Length:	737	Identity:	176/737 - (23%)
Similarity:	283/737 - (38%)	Gaps:	169/737 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 ATNTCFGSKL----PYELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCE 156
            |.||.|...|    ..:.::|.:..||....|              :|...|:|||||::.|.|.
Zfish    42 AYNTTFMPNLLNHYDQQTAALAMEPFHPMVNL--------------ECSTEIRPFLCALYAPVCT 92

  Fly   157 KINGEDMVYLPSYEMCRITMEPCRILYNT--TFFPKFLRCNETLFPTKCTNGARGMKFNGTGQCL 219
            :..   .|.||...:|:.....|..|...  ..:|..:.|:.  ||....:..|.:
Zfish    93 EYG---RVTLPCRRLCQRAKSDCYKLMEMFGVSWPDEMECSR--FPECEESYPRAI--------- 143

  Fly   220 SPLVPTDTSASYYP--------------------------GIEGCGVRCKDPLYTDDEHRQIHKL 258
             .|:|:..|....|                          |:..|...|.:..:..||.......
Zfish   144 -DLLPSSDSTEESPSAVQRDYGFWCPRELKIEPDLGYSFMGVRDCSPPCPNMYFRKDELIFARYF 207

  Fly   259 IGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKD 323
            ||....:||.:.||...||.|| ....:||...:.:..:|:::..:.:.|.|....|........
Zfish   208 IGVISIVCLSATLFTFLTFLID-VGRFRYPERPIIFYAVCYMMVSLVFFLGFLLEDRVSCNTASP 271

  Fly   324 GTLRHSEPTAG-ENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRAM---GHVQDRIDKKGSYFH 384
            |..|.|..|.| .|.:|.::|:.:|:|..||.||:|.||..|...|:   |  .:.|:||...||
Zfish   272 GRFRASTITQGSHNKACTLLFMTLYFFTMAGSVWWVILTITWFLAAVPKWG--SEAIEKKALLFH 334

  Fly   385 LVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVML 449
            .|||.:|..||||.||.::::|:|:.|:||||..:.......||.||...:::|...:..|:..|
Zfish   335 AVAWGVPGALTITLMAMNKIEGDSMSGVCFVGLYDLMALRWFLLVPLVLDVIVGVVLLLAGIAAL 399

  Fly   450 FGLKHFANDIK-----STSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQ 509
                   |.::     .....:|:...::|:||.::|.||.:|..|.|::.|..|...|..::.|
Zfish   400 -------NRVRMEIPLEKENQDKLVKFMIRIGVFSVLYLVPLLTVIGCYLYEQSHRSVWETTWVQ 457

  Fly   510 ------FIICKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYI- 567
                  .|.|...   .||:|     ||.:.:..:..|.:...||....|..:..:...|..:.
Zfish   458 ERCREYHIPCPFK---VEKTS-----RPDIALFLIKYLMMLVVGIPSVFWVGSKKTCFEWASFFS 514

  Fly   568 --RKKC-----GKEVVEE-------VKMPKHKVIAQTWAKRKDFEDKGRLSITLYNTHTDPVGLN 618
              |:|.     .::|::|       ::.|...|:    .|.:....:|.      :||.
Zfish   515 GHRRKDSAVHESRQVLQEPDFTQLLLRDPNTPVV----RKSRGTSTQGT------STHA------ 563

  Fly   619 FDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSS-HGPRKNSLDSEISVSVRHVSVE 682
                          |||..|.|.:......:..|:....||| ||....|.|...:.| ....||
Zfish   564 --------------SSTHLAMLDEPPSASTSRAGSTRSKSSSFHGSLHRSRDGRYTAS-SFRGVE 613

  Fly   683 SRRNSVDSQVSVKIAEMKTKVASR---SRGKHGGSSSNRRTQRRRDYIAAATGKSSRRRESST-- 742
            .|   |....|:::.|.....|..   |:.:||   |.:|.:             |:.|.||.
Zfish   614 ER---VSHGSSLRLNEPLQHCAINRLDSQSRHG---SLQRLE-------------SQSRHSSVRD 659

  Fly   743 -SVESQVIALKKTTYPNASHKV 763
             |:.:|.|   :::..|..|:|
Zfish   660 LSITAQAI---QSSPGNGIHRV 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	29/130 (22%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	94/339 (28%)
fzd3a	XP_005160805.1	CRD_FZ3	26..152	CDD:143558	31/138 (22%)
fzd3a	XP_005160805.1	Frizzled	195..513	CDD:279827	94/335 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810