Protein Alignment smo and fzd9a

DIOPT Version :9

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: XP_003198734.2
• Gene: fzd9a / 557447
• ZFINID: ZDB-GENE-060531-77
• Length: 581
• Species: Danio rerio
• Alignment Length: 578
• Identity: 145/578 - (25%)
• Similarity: 261/578 - (45%)
• Gaps: 87/578 - (15%)

  Fly    86 RRARCYPTSNATNTCFGSKLPYELSSL-DLTDFHTEKELNDKLNDYYAL-KHVPKCWAAIQPFLC 148
            |..:|.|.:  ...|.|  :.|.::.: :|.::.:::|.:.|||::..| |:  .|...:|.|||
Zfish    32 RPGKCEPIT--IPMCQG--IGYNMTRMPNLLNYESQEEASIKLNEFAPLVKY--GCDIHLQFFLC 90

  Fly   149 AVFKPKC-EKINGEDMVYLPSYEMCRITMEPCRILYNTTF-FPKFLRCNETLFPTK------CTN 205
            :::.|.| |:::.......|..|..|....|  |:...:| :|..|.|::  .||.      |..
Zfish    91 SLYVPMCAEQVSASIPACRPMCEQARQRCSP--IMEQFSFSWPDSLDCSK--LPTNNDPNALCIE 151

  Fly   206 GARGMKFNGT------GQCLSPLVPTD---TSAS-----------------YYPGIEGCGVRCK- 243
            ...    |.|      |:.:.|:.|..   |:.|                 |....|.|..||.
Zfish   152 APE----NDTQPETKKGEGMLPVPPRSRQPTTVSGRISSISQSCENPEKFQYVDKSESCAPRCTP 212

  Fly   244 --DPLYT-DDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVG 305
              |..:: .|:......::.|: ::|.:|..|.|.||.:| ....:||...:.::::|:.|..|.
Zfish   213 TVDVYWSRQDKDFAFIWMVVWS-TLCFVSTAFTVLTFLLD-PQRFQYPERPIIFLSMCYNIYSVA 275

  Fly   306 WLLQFTSGSREDIVC-RKDGTL---RHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWH- 365
            ::::..:|: |:|.| |::|.|   |....:.|    |.::|:::|||..|..:|:|.||..|.
Zfish   276 FIIRSVAGA-ENIACDRENGELYIIREGLESTG----CTIVFLILYYFGMASSIWWVILTLTWFL 335

  Fly   366 --WRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLL 428
              .|..||  :.|:...||||:.||.:|.|.||..:...:|.|:.:.|:|:||.::.|...|.:|
Zfish   336 AAGRKWGH--EAIEAHSSYFHMAAWGIPAVKTIVILTMRKVAGDELTGLCYVGSMDSSALTGFVL 398

  Fly   429 GPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASN--KIHLIIMRMGVCALLTLVFILVAIA 491
            .||...:::|..||..|.|.||.::    .|..|..:|  |:..:::::||.::|..|...:.|.
Zfish   399 IPLSCYLIVGTSFILTGFVALFHIR----KIMKTGGTNTEKLEKLMVKIGVFSILYTVPATIVII 459

  Fly   492 CHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENR-PSVGVLQLHLLCLFSSGIVMSTWCW 555
            |:..|..:.:.|  .||......:|........|.:::. |:|.|..|.:......||....|.|
Zfish   460 CYFYERLNMEYW--KFRALENKCVSFPGRRSDDCSLDSSVPTVAVFMLKIFMSLVVGITSGVWVW 522

  Fly   556 TPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSITLYNTHTD 613
            :..:::||:....::.|.:.       .||..:...........|.. ::|::...||
Zfish   523 SSKTLQTWQGLCNRRLGVQT-------SHKPCSSVSCSNSHCHYKAP-AVTVHMNKTD 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	36/150 (24%)
		Frizzled	246..568	CDD:279827	92/332 (28%)
fzd9a	XP_003198734.2	CRD_FZ	32..157	CDD:321937	34/138 (25%)
		7tmF_FZD9	216..535	CDD:320164	92/333 (28%)
		TM helix 1	225..250	CDD:320164	7/25 (28%)
		TM helix 2	259..280	CDD:320164	3/20 (15%)
		TM helix 3	309..335	CDD:320164	10/25 (40%)
		TM helix 4	352..368	CDD:320164	9/15 (60%)
		TM helix 5	390..420	CDD:320164	10/29 (34%)
		TM helix 6	439..466	CDD:320164	7/26 (27%)
		TM helix 7	496..521	CDD:320164	6/24 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920