DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and fzd7

DIOPT Version :10

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_001016741.1 Gene:fzd7 / 549495 XenbaseID:XB-GENE-483731 Length:548 Species:Xenopus tropicalis


Alignment Length:523 Identity:133/523 - (25%)
Similarity:227/523 - (43%) Gaps:116/523 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 HTEKE-LNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRI 181
            ||.:| ...:::.:|.|..| :|...::.|||:::.|.|..:   :....|...:|....:.|..
 Frog    60 HTNQEDAGLEVHQFYPLVKV-QCSPELRFFLCSMYAPVCTVL---EQAIPPCRSLCERARQGCEA 120

  Fly   182 LYNTTFF--PKFLRCNETLFPTKCTNGARGMKFNGTGQ-CL-------SPLVPTDTSASYYP--- 233
            |.|...|  |:.|||..  ||           .:|.|: |:       ||..||.....|.|   
 Frog   121 LMNKFGFQWPERLRCEN--FP-----------IHGAGEICVGQNTSDNSPSGPTARPTPYLPDSI 172

  Fly   234 ---------------------------GIEGCGVRCKDP------LYTDDEHRQIHKLIGWAG-- 263
                                       |.:.||..| :|      :|..:|..:..:|  |.|  
 Frog   173 TFHPHLNRDFTCPRQLKVPPYLGYRFLGEKDCGAPC-EPGKANGLMYFKEEEVRFARL--WVGIW 234

  Fly   264 -SICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACV----GWLLQFTSGSREDIVC--- 320
             .:|.:|.||.|.|:.:|.:..: ||...:.:::.|:.:..|    |:||:      |..||   
 Frog   235 AILCGISTLFTVLTYLVDMRRFS-YPERPIIFLSGCYFMVAVAYTAGFLLE------ERGVCVER 292

  Fly   321 -RKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGS 381
             .:|.....::.|..|  .|.::|:::|:|..|..:|:|.|:..|...|   .||  :.|:....
 Frog   293 FSEDSYRTVAQGTKKE--GCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGH--EAIEANSQ 353

  Fly   382 YFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGM 446
            ||||.||::|.|.|||.:|..:|||:.:.|:|:||..:.....|.:|.||...:.||..|:..|.
 Frog   354 YFHLAAWAVPAVKTITILAMGQVDGDILSGVCYVGINSVDSLRGFVLAPLFVYLFIGTSFLLAGF 418

  Fly   447 VMLFG----LKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSF 507
            |.||.    :||      ..:.:.|:..:::|:||.:::..|...:.:||:..|....|.|.:: 
 Frog   419 VSLFRIRTIMKH------DGTKTEKLEKLMVRIGVFSVMYTVPATIVLACYFYEQAFRDTWEKT- 476

  Fly   508 RQFII--CKISSVFEEKSSCRIEN----RPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRY 566
              :::  ||..:|     .|...|    .|...|..:..|.....||..|.|.|:..::::|:|:
 Frog   477 --WLVQTCKGFAV-----PCPNYNFAPMSPDFTVFMIKYLMTMIVGITSSFWIWSGKTLQSWRRF 534

  Fly   567 IRK 569
            ..:
 Frog   535 YHR 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 27/113 (24%)
7tmF_SMO_homolog 245..568 CDD:320158 96/352 (27%)
TM helix 1 254..279 CDD:320158 9/27 (33%)
TM helix 2 289..310 CDD:320158 5/24 (21%)
TM helix 3 340..366 CDD:320158 8/25 (32%)
TM helix 4 382..398 CDD:320158 10/15 (67%)
TM helix 5 420..449 CDD:320158 9/28 (32%)
TM helix 6 471..498 CDD:320158 7/26 (27%)
TM helix 7 529..554 CDD:320158 7/28 (25%)
fzd7NP_001016741.1 CRD_FZ7 32..156 CDD:143575 27/112 (24%)
7tmF_FZD7 217..547 CDD:320374 95/348 (27%)
TM helix 1 226..251 CDD:320374 9/26 (35%)
TM helix 2 260..281 CDD:320374 2/20 (10%)
TM helix 3 311..337 CDD:320374 8/25 (32%)
TM helix 4 354..370 CDD:320374 10/15 (67%)
TM helix 5 392..421 CDD:320374 9/28 (32%)
TM helix 6 441..468 CDD:320374 7/26 (27%)
TM helix 7 497..522 CDD:320374 6/24 (25%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 526..531 0/4 (0%)
PDZ-binding. /evidence=ECO:0000255 546..548
Blue background indicates that the domain is not in the aligned region.

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