Protein Alignment smo and fz

DIOPT Version :9

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 155/598 - (25%)
• Similarity: 264/598 - (44%)
• Gaps: 124/598 - (20%)

  Fly    53 PINGTLNYR----LYAKKGRDDKPWFDGLDSRHIQCVRRARCYPTSNATNTCFGSKLPYELSSLD 113
            |::.:..||    |.|..|.:    .|||...:       ||.|.:  .:.|  ..:||.::.:.
  Fly    23 PLDASPYYRSGGGLMASSGTE----LDGLPHHN-------RCEPIT--ISIC--KNIPYNMTIMP 72

  Fly   114 LTDFHT-EKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITME 177
            ....|| ::|...:::.:..|..: .|...:|.|||:::.|.|..:...    :|.   ||...|
  Fly    73 NLIGHTKQEEAGLEVHQFAPLVKI-GCSDDLQLFLCSLYVPVCTILERP----IPP---CRSLCE 129

  Fly   178 PCRI------LYNTTFFPKFLRCNETLFPTKCTNGARGM--KFNGTGQCLSPLVPTD-----TSA 229
            ..|:      .||.. :|:.|.|::  ||   .:|...:  ..|.|....:...||.     |:.
  Fly   130 SARVCEKLMKTYNFN-WPENLECSK--FP---VHGGEDLCVAENTTSSASTAATPTRSVAKVTTR 188

  Fly   230 SYYPGIEG--------------------------------CGVRCKDPLYTDDEHRQIHKLIG-W 261
            .:..|:|.                                ||..|....:.:.|...:...:| |
  Fly   189 KHQTGVESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPERERTVLRYWVGSW 253

  Fly   262 AGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCR----- 321
            | ::|:.|.||.|.||.|| .:..:||...:.::.:|:|:  ||.......|:.:.:.||
  Fly   254 A-AVCVASCLFTVLTFLID-SSRFRYPERAIVFLAVCYLV--VGCAYVAGLGAGDSVSCREPFPP 314

  Fly   322 --KDGTLR-HSEPTAG--ENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDK 378
              |.|.|: .|..|.|  :..||.|:|:.:|:...|...|:..|.:||...|   .||  :.|:.
  Fly   315 PVKLGRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGH--EAIEN 377

  Fly   379 KGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYIN-HSMRAGLLLGPLCGVILIGGYFI 442
            |...||||||::|.:.||:.:|.::|:|:.:.|:||||.:: ||:.|.|:| |||..:.||..|:
  Fly   378 KSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLIL-PLCIYLSIGALFL 441

  Fly   443 TRGMVMLFGLKH-FANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAI---ACHVTEFRHADEW 503
            ..|.:.||.::. ...|.|.|   :|:..:::|:|   ..:.:|||.|:   .|...|:.:.|||
  Fly   442 LAGFISLFRIRTVMKTDGKRT---DKLERLMLRIG---FFSGLFILPAVGLLGCLFYEYYNFDEW 500

  Fly   504 AQSFRQFIICKISSVFEEKSSCRI-------ENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIE 561
            ...:.: .|||..|:     .|..       |.||...:..:..||....|:..|.|.::..::.
  Fly   501 MIQWHR-DICKPFSI-----PCPAARAPGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMV 559

  Fly   562 TWKRYIRKKCGKE 574
            :|:.::.:..|||
  Fly   560 SWRNFVERLQGKE 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	32/143 (22%)
		Frizzled	246..568	CDD:279827	103/347 (30%)
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	30/140 (21%)
		Frizzled	237..564	CDD:279827	103/345 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438644
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840