Protein Alignment smo and fzd10

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_001005669.1
• Gene: fzd10 / 448162
• XenbaseID: XB-GENE-480379
• Length: 585
• Species: Xenopus tropicalis
• Alignment Length: 560
• Identity: 139/560 - (24%)
• Similarity: 246/560 - (43%)
• Gaps: 91/560 - (16%)

  Fly    92 PTSNATNTCFGSKLP------YELSSL-DLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCA 149
            |..:....|...::|      |.::.: :|.....:||...:|:::..|... .|.:.::.|||:
 Frog    31 PDRSGDGRCQPIEIPMCKDIGYNMTRMPNLMGHENQKEAAIQLHEFAPLVEY-GCHSHLKFFLCS 94

  Fly   150 VFKPKC-EKINGEDMVYLPSYEMCRITMEPCR-----ILYNTTF-FPKFLRCNETLFPTK----- 202
            ::.|.| |:::    ..:|:   ||:..|..|     |:....| :|..|.|::  .|.|
 Frog    95 LYAPMCTEQVS----TPIPA---CRVMCEQARLKCSPIMEQFNFKWPDSLDCSK--LPNKNDPNY 150

  Fly   203 -C----TNGA----RGMKF---------NGTGQCLSPLVPTDTSASYYPG----IE---GCGVRC 242
             |    .||:    ||...         ..:|..:.|..||..:.....|    :|   .|...|
 Frog   151 LCMEAPNNGSEEAPRGSSMLPPIFRPQRPNSGHEIYPKDPTGRTTCENSGKFHHVEKSASCAPLC 215

  Fly   243 K---DPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACV 304
            .   |..::.|:.:.....|.....:|..|:.|.|.||.:| ....|||...:.::::|:.:..|
 Frog   216 SSAVDVYWSKDDKKFAFIWIAIWSILCFFSSAFTVLTFLVD-PLRFKYPERPIIFLSMCYCVYSV 279

  Fly   305 GWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA- 368
            |::::..:|: :.|.|.:|....:......|:..|.::|:::|||..|..:|:|.||..|...|
 Frog   280 GYIIRLFAGA-DSIACDRDSGQLYVIQEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAG 343

  Fly   369 --MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPL 431
              .||  :.|:...|||||.||::|.|.||..:....|.|:.:.|:|:||.::.:...|.:|.||
 Frog   344 KKWGH--EAIEANSSYFHLAAWAIPAVKTIMILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPL 406

  Fly   432 CGVILIGGYFITRGMVMLFGLKHFANDIKSTSASN--KIHLIIMRMGVCALLTLVFILVAIACHV 494
            ...::||..||..|.|.||.::.    :..|...|  |:..:::|:||.::|..|.....|||:.
 Frog   407 ACYLIIGTSFILSGFVALFHIRR----VMKTGGENTDKLEKLMVRIGVFSVLYTVPATCVIACYF 467

  Fly   495 TEFRHADEWAQSFRQFII-----CKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWC 554
            .|..:.|.|.      |:     ||:.|..:........:.|:|.:..:.:..|...||....|.
 Frog   468 YERLNMDFWK------ILATQDKCKMDSQTKTLDCTMTSSIPAVEIFMVKIFMLLVVGITSGMWI 526

  Fly   555 WTPSSIETWKRYIRKKCGK-------EVVEEV---KMPKH 584
            ||..::::|:....|:..|       .|:...   |.|:|
 Frog   527 WTSKTVQSWQNVFSKRLKKRNRSKPASVITSAGIYKKPQH 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	34/165 (21%)
		7tmF_SMO_homolog	245..568	CDD:320158	91/332 (27%)
		TM helix 1	254..279	CDD:320158	7/24 (29%)
		TM helix 2	289..310	CDD:320158	3/20 (15%)
		TM helix 3	340..366	CDD:320158	10/25 (40%)
		TM helix 4	382..398	CDD:320158	10/15 (67%)
		TM helix 5	420..449	CDD:320158	10/28 (36%)
		TM helix 6	471..498	CDD:320158	9/26 (35%)
		TM helix 7	529..554	CDD:320158	5/24 (21%)
fzd10	NP_001005669.1	CRD_FZ10	35..161	CDD:143571	30/135 (22%)
		7tmF_FZD10	221..540	CDD:320165	91/332 (27%)
		TM helix 1	230..255	CDD:320165	7/24 (29%)
		TM helix 2	264..285	CDD:320165	3/20 (15%)
		TM helix 3	314..340	CDD:320165	10/25 (40%)
		TM helix 4	357..373	CDD:320165	10/15 (67%)
		TM helix 5	395..424	CDD:320165	10/28 (36%)
		TM helix 6	444..471	CDD:320165	9/26 (35%)
		TM helix 7	501..526	CDD:320165	5/24 (21%)