Protein Alignment smo and fzd6

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_956855.2
• Gene: fzd6 / 393533
• ZFINID: ZDB-GENE-040426-1451
• Length: 617
• Species: Danio rerio
• Alignment Length: 651
• Identity: 141/651 - (21%)
• Similarity: 248/651 - (38%)
• Gaps: 131/651 - (20%)

  Fly   105 LPYELSSLDLTDFHTEKELND-KLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDM---VY 165
            :||..:.......|.::::.. ::.::..|..| :|......|||..|.|:|........   |.
Zfish    35 MPYNTTFFPNMLEHYDQDIAAVRMKEFMPLVSV-RCSPDAHLFLCQAFVPECRTHTHSQTHTHVL 98

  Fly   166 LPSYEMCRITMEPCRILYNT--TFFPKFLRCNETLFPTKCTNGARGMKFNG-TGQCLSP------ 221
            .|..|.|......||.:.:|  ..:|..|:|...   ..|...|..:...| :|...||
Zfish    99 RPCRERCERVRSDCRAVMHTFDISWPSELQCERL---ESCGGSAVDVTTAGRSGAGSSPRDLGFW 160

  Fly   222 ------LVPTDTSASYYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFID 280
                  |.|..:.:  :.|...|...|::...|..|.......||....:||.:.||...||.:|
Zfish   161 CPLQLKLRPGQSGS--FLGAPDCAPPCENMFLTAAEQHLARLFIGVCSVVCLCATLFTFLTFLMD 223

  Fly   281 WKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLRHSEP-------TAGENLS 338
            .:.. :||...:.:|::|:....:.:||.|..|  ..:.|...|     .|       ....:..
Zfish   224 AQRF-RYPERPIVFISVCYCAVSLLYLLGFMLG--PSVACGAPG-----RPGGVWTVVLGARSRG 280

  Fly   339 CIVIFVLVYYFLTAGMVWFVFLTYAW------HWRAMGHVQDRIDKKGSYFHLVAWSLPLVLTIT 397
            |.::|.|:|:..||||:|:|.||..|      .|..     :.|.|:..:||...|.:|.|||:.
Zfish   281 CSLLFTLLYFCSTAGMLWWVILTITWFLAAGPKWSC-----EAIQKQALWFHAAGWGVPAVLTLL 340

  Fly   398 TMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKST 462
            .:|..:|:|:.|.|:||.|..:.:.....|:.||...:|:|...:..|:|.|       |.::..
Zfish   341 LLALGKVEGDGISGVCFTGLYDLTALRWFLVAPLALAVLLGLALLLAGIVAL-------NRVRQV 398

  Fly   463 SA-----SNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSF--RQFIICKISSVFE 520
            ..     ..|:...::|:||.:.|.|:.:|:.:.|::.|......|..|:  |.   |:..|:..
Zfish   399 IQHDQLNQQKLKRFMIRIGVFSGLYLLPLLLLLGCYLYEMTQRRVWESSWVNRH---CQEFSIPC 460

  Fly   521 EKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHK 585
            .::|......|.:.:..|..|...:.||....|..:..:...|..:.|:...|:.|.|    ..:
Zfish   461 ARTSSGGVQHPGLSLFLLKYLMTLAVGIPAVFWVSSRKTCSRWASFCRRAHKKDAVSE----SRR 521

  Fly   586 VIAQT---WAKRKDFEDKGRLSITLYNTHTDPVGLNFDVNDLNSSETNDISSTWAAYLPQCVKRR 647
            |:.::   :.|......:.|.|:.|                                  :.:.:.
Zfish   522 VLQESCEFFLKHNSRPQQSRSSLRL----------------------------------KVLSKS 552

  Fly   648 MALTGAATGNSSSHGPRKNSLDSEISVSVRHVSVES---RRNSVDSQVSVKIAEMKTKVASRSRG 709
            |   |.:||..:|..|..       :.|:.|.:..|   |.:..|:         .::::|||..
Zfish   553 M---GTSTGTPASCAPPP-------AASLDHTAASSDTDRHSRADA---------SSRISSRSTS 598

  Fly   710 K 710
            |
Zfish   599 K 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	26/122 (21%)
		7tmF_SMO_homolog	245..568	CDD:320158	84/342 (25%)
		TM helix 1	254..279	CDD:320158	8/24 (33%)
		TM helix 2	289..310	CDD:320158	4/20 (20%)
		TM helix 3	340..366	CDD:320158	12/31 (39%)
		TM helix 4	382..398	CDD:320158	7/15 (47%)
		TM helix 5	420..449	CDD:320158	7/28 (25%)
		TM helix 6	471..498	CDD:320158	8/26 (31%)
		TM helix 7	529..554	CDD:320158	5/24 (21%)
fzd6	NP_956855.2	None