Protein Alignment smo and Fzd8

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_001037716.1
• Gene: Fzd8 / 364754
• RGDID: 1560525
• Length: 684
• Species: Rattus norvegicus
• Alignment Length: 593
• Identity: 134/593 - (22%)
• Similarity: 216/593 - (36%)
• Gaps: 175/593 - (29%)

  Fly   119 TEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCR--- 180
            |:.|...:::.::.|..: :|...::.|||:::.|.|          |..|:.   .:.|||
  Rat    61 TQDEAGLEVHQFWPLVEI-QCSPDLKFFLCSMYTPIC----------LEDYKK---PLPPCRSVC 111

  Fly   181 ---------ILYNTTF-FPKFLRC----------------NETLFPTKCTN-------------- 205
                     ::....| :|..:||                |.|...|...:
  Rat   112 ERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPQPGEQP 176

  Fly   206 ----------GA----RGMKFNGTG---------------------------QCLSPLVPTDTSA 229
                      ||    ||....|:|                           ||.:|:|  ..|:
  Rat   177 PSGSGHSRPPGARPPHRGGSSRGSGDTAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMV--SVSS 239

  Fly   230 SYYP--------GIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANK 286
            ..:|        .|..|.:.|.:|.::.||.......||....:|.:|....||||.||.:.. |
  Rat   240 ERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERF-K 303

  Fly   287 YPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCR-----------KDGTLRHSEPTAGENLS-- 338
            ||...:.:::.|:|...||:|::..:| .|.:.|.           ..|........||...|
  Rat   304 YPERPIIFLSACYLFVSVGYLVRLVAG-HEKVACSGGAPGAGGAGGAGGAATAGAGAAGAGASSP 367

  Fly   339 -------------------------CIVIFVLVYYFLTAGMVWFVFLTYAWHWRA-MGHVQDRID 377
                                     |.|:|:|||:|..|..:|:|.|:..|...| |....:.|.
  Rat   368 GARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIA 432

  Fly   378 KKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFI 442
            ....||||.||.:|.|.:|..:|.|.|||:.:.|||:||..:.....|.:|.||...:.||..|:
  Rat   433 GYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFL 497

  Fly   443 TRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSF 507
            ..|.|.||.::.........:.::|:..:::|:|:..:|..|...|.:||...|..:...|
  Rat   498 LAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRW---- 558

  Fly   508 RQFIICKISSVFEEKSSCRI--------ENRPSVGVLQL-HLLCLFSSGIVMSTWCWTPSSIETW 563
                        |...:|..        ..||...|..| :.:||. .||....|.|:..::|:|
  Rat   559 ------------EATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLV-VGITSGVWVWSGKTLESW 610

  Fly   564 KRYIRKKC 571
            :....:.|
  Rat   611 RALCTRCC 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	29/185 (16%)
		7tmF_SMO_homolog	245..568	CDD:320158	97/370 (26%)
		TM helix 1	254..279	CDD:320158	8/24 (33%)
		TM helix 2	289..310	CDD:320158	5/20 (25%)
		TM helix 3	340..366	CDD:320158	11/25 (44%)
		TM helix 4	382..398	CDD:320158	9/15 (60%)
		TM helix 5	420..449	CDD:320158	9/28 (32%)
		TM helix 6	471..498	CDD:320158	8/26 (31%)
		TM helix 7	529..554	CDD:320158	8/25 (32%)
Fzd8	NP_001037716.1	CRD_FZ8	31..155	CDD:143570	19/107 (18%)
		Wnt-binding. /evidence=ECO:0000250	95..100		2/14 (14%)
		Wnt-binding. /evidence=ECO:0000250	147..152		0/4 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..222		7/66 (11%)
		7tmF_FZD8	263..615	CDD:320378	97/370 (26%)
		TM helix 1	272..297	CDD:320378	8/24 (33%)
		TM helix 2	306..327	CDD:320378	5/20 (25%)
		TM helix 3	394..416	CDD:320378	10/21 (48%)
		TM helix 4	437..453	CDD:320378	9/15 (60%)
		TM helix 5	475..498	CDD:320378	7/22 (32%)
		TM helix 6	528..553	CDD:320378	8/24 (33%)
		TM helix 7	576..601	CDD:320378	8/25 (32%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	605..610		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	630..655
		PDZ-binding. /evidence=ECO:0000250	682..684