Protein Alignment smo and Fzd10

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_001258121.1
• Gene: Fzd10 / 363913
• RGDID: 1583825
• Length: 582
• Species: Rattus norvegicus
• Alignment Length: 515
• Identity: 137/515 - (26%)
• Similarity: 229/515 - (44%)
• Gaps: 79/515 - (15%)

  Fly   113 DLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITM 176
            :|.....::|...:|:::..|... .|...::.|||:::.|.| |:::    ..:|:   ||:..
  Rat    55 NLMGHENQREAAIQLHEFAPLVEY-GCHGHLRFFLCSLYAPMCTEQVS----TPIPA---CRVMC 111

  Fly   177 EPCR-----ILYNTTF-FPKFLRCNETLFPTK---------CTNGARGMKFNGTGQCLSPLVPTD 226
            |..|     |:....| :|..|.|::  .|.|         ..|........|:|. ..||....
  Rat   112 EQARLKCSPIMEQFKFRWPDSLDCSK--LPNKNDPNYLCMEAPNNGSDEPSRGSGM-FPPLFRPQ 173

  Fly   227 T--SASYY------PGIEGC-----------GVRCKDPLYT---------DDEHRQIHKLIGWAG 263
            .  ||..:      ||..||           ...|. ||.|         ||:...:..|..|:
  Rat   174 RPHSAQEHPLKDGGPGRAGCDNPGKFHHVEKSESCA-PLCTPGVDVYWSRDDKRFAVVWLAIWS- 236

  Fly   264 SICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLRH 328
            .:|..|:.|.|.||.|| .:..:||...:.::::|:.:..||::::..:|: |.|.|.:|....:
  Rat   237 VLCFFSSAFTVLTFLID-PSRFRYPERPIIFLSMCYCVYSVGYIIRLFAGA-ESIACDRDSGQLY 299

  Fly   329 SEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWH---WRAMGHVQDRIDKKGSYFHLVAWSL 390
            ......|:..|.::|:::|||..|..:|:|.||..|.   .|..||  :.|:...|||||.||::
  Rat   300 VIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGRKWGH--EAIEANSSYFHLAAWAI 362

  Fly   391 PLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHF 455
            |.|.||..:....|.|:.:.|:|:||.::.:...|.:|.||...::||..||..|.|.||.::.
  Rat   363 PAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRR- 426

  Fly   456 ANDIKSTSASN--KIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSV 518
               :..|...|  |:..:::|:||.:||..|.....|||:..|..:.|.|.....|. .||.::.
  Rat   427 ---VMKTGGENTDKLEKLMVRIGVFSLLYTVPATCVIACYFYERLNMDYWKMLATQH-KCKTNNQ 487

  Fly   519 FEEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETW--------KRYIRKK 570
            .:........:.|:|.|..:.:..|...||....|.||..::::|        ||..|:|
  Rat   488 TKTADCLMTTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQQVCSRGLKRKSRRK 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	26/123 (21%)
		7tmF_SMO_homolog	245..568	CDD:320158	100/344 (29%)
		TM helix 1	254..279	CDD:320158	8/24 (33%)
		TM helix 2	289..310	CDD:320158	3/20 (15%)
		TM helix 3	340..366	CDD:320158	10/28 (36%)
		TM helix 4	382..398	CDD:320158	10/15 (67%)
		TM helix 5	420..449	CDD:320158	10/28 (36%)
		TM helix 6	471..498	CDD:320158	10/26 (38%)
		TM helix 7	529..554	CDD:320158	6/24 (25%)
Fzd10	NP_001258121.1	CRD_FZ	31..157	CDD:470581	24/111 (22%)
		7tmF_FZD10	218..537	CDD:320165	95/328 (29%)
		TM helix 1	227..252	CDD:320165	8/25 (32%)
		TM helix 2	261..282	CDD:320165	3/20 (15%)
		TM helix 3	311..337	CDD:320165	10/25 (40%)
		TM helix 4	354..370	CDD:320165	10/15 (67%)
		TM helix 5	392..421	CDD:320165	10/28 (36%)
		TM helix 6	441..468	CDD:320165	10/26 (38%)
		TM helix 7	498..523	CDD:320165	6/24 (25%)