DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and Corin

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	171	Identity:	43/171 - (25%)
Similarity:	66/171 - (38%)	Gaps:	27/171 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 CYPTSNATNTCFGSKLPYELSSL-DLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKP 153
            |.|.  ....|.|.::||..:.. :......:.|....|:.|.||..| :|:..:..|||.:|.|
  Fly   779 CLPI--IVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDV-RCYELVSLFLCTLFVP 840

  Fly   154 KCEKINGEDMVYLPSYE-MCRITMEPCRILYNT--TFFPKFLRCNETLFPTKCTNGARGMKFNGT 215
            ||    |:....:|..: :|..||..|...::.  ...|::|.|.  ||          ..|..:
  Fly   841 KC----GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCK--LF----------KDFPSS 889

  Fly   216 GQCLS-PLVPTDTSASYYPGIEG--CGV-RCKDPLYTDDEH 252
            ..|:. ..|.....|:.:|..:|  |.. ||....|..|.|
  Fly   890 EDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGH 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	33/135 (24%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	3/7 (43%)
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	33/133 (25%)
		LDLa	911..942	CDD:238060	7/20 (35%)
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900