DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and CG1632

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster

Alignment Length:	360	Identity:	70/360 - (19%)
Similarity:	105/360 - (29%)	Gaps:	125/360 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   697 AEMKTKVASRSRGKHGGSSSNRRTQRRRDYIAAATGKSSRRRESSTSVESQVIALKKT------T 755
            ::||   .||...|...:.|...|......::||..|::....|:.:.|..:.|..|.      :
  Fly    10 SQMK---KSRDADKSSATLSATNTNANAVNLSAADKKNNNNNCSNRNKEKSMQANGKNWKGIVQS 71

  Fly   756 YPNASHKVGVFA-------------HHSSKKQHNYTSSMKRRTANAGLDPSILNEFLQKNGDFIF 807
            .||.|..||..|             ||.....|...|:.......|||          .||.
  Fly    72 NPNPSGGVGTTAQPPKVFHNTRCTRHHKPHHSHGNGSAASAVGGAAGL----------ANGP--- 123

  Fly   808 PFLQNQDMSSSSEEDNSRASQKIQDLNVVVKQQEISEDDHDGIKIEELPNSKQVALENFLKNIKK 872
            |....|......|.|..|..::.:|          .|.|.:                       :
  Fly   124 PMEATQQRERERERDRDRERERERD----------RERDRE-----------------------R 155

  Fly   873 SNESNSNRHSRNSARSQSKKSQKRHLKNPAADLDFRKDCVKYRSNDSLSCSSEELDVALDVGSLL 937
            ..|...:.|..|....:..:|..      :.|.|.|  ..:.:..|...|.     .|:..|.|:
  Fly   156 EREHQLHMHQHNHGLRRKSESVL------STDSDIR--FTRRKLGDGQKCG-----CAVIAGFLI 207

  Fly   938 NSSFSGI--SMGKPHSR----------------NSKTSCDVGIQANPFELVPSYGEDELQQAMRL 984
            ....:||  .:|..:.|                |.|.|.::   ||             |.:||.
  Fly   208 ALLVAGIFVYVGYTYFRPEPLPDRVFRGRFMVLNDKWSMEL---AN-------------QNSMRF 256

  Fly   985 LNAASRQRTEAAN---------EDFGGTELQGLLG 1010
            .:.| |...|..|         |.:.|:|:..|.|
  Fly   257 QHKA-RDYRERINLTLRRSDLREAYEGSEILALDG 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560
smo	NP_523443.1	Frizzled	246..568	CDD:279827
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	17/76 (22%)
		CRD_FZ	384..502	CDD:143549
		PRKCSH-like	<503..>582	CDD:193472
		LDLa	536..571	CDD:238060
		Tryp_SPc	708..>809	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900