DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and fz4

DIOPT Version :10

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_511068.2 Gene:fz4 / 31659 FlyBaseID:FBgn0027342 Length:705 Species:Drosophila melanogaster


Alignment Length:881 Identity:176/881 - (19%)
Similarity:269/881 - (30%) Gaps:316/881 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 ILCLWVVA---DASASSAKFGSTTPASAQQSDVELEPINGTLNYRLYAKKGRDDKPWFDGLDSRH 81
            ||||.||.   ...:.|:..|:.:.:|:..|..|:                    |.|     |.
  Fly     6 ILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEI--------------------PAF-----RQ 45

  Fly    82 IQCVRRARCYPTSNATNTCFGSKLPY-ELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQP 145
            .:.:|...|            .|:.| |.|..:|.....:.::...|..:..|... .|.:.::.
  Fly    46 CETIRIEMC------------RKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEY-DCSSQLKL 97

  Fly   146 FLCAVFKPKCEKINGEDMVYL--PSYEMC---RITMEPCRILYNTTF-FPKFLRCNETLFPTKCT 204
            ||||.:.|.|   ..:..|:.  |...:|   ||...|  :|....| :|..|.|::  ||.:  
  Fly    98 FLCAAYVPMC---TPKAPVHAIGPCRSLCESVRIRCHP--VLQGFGFPWPPALDCDK--FPRE-- 153

  Fly   205 NGARGMKFNGTGQCLSPLVPTDTSASYYPGIEG---------------------------CGVRC 242
            |....|...|.|:...|....|.......||.|                           |...|
  Fly   154 NNHETMCMEGPGELHQPQQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLC 218

  Fly   243 K-DPLYTDDEHRQIHKLIG-WA---------GSICLLSNLFVVSTFFID--------WKNANKYP 288
            : |.|:|..|.......:. ||         .::|||::         |        |..     
  Fly   219 EADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLAS---------DGSRLASAKWSR----- 269

  Fly   289 AVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLRHSEPTAG----------ENLSCIVIF 343
              ::..:..|..:..:||.::|..|        :.||...::|.|.          .|.||..:|
  Fly   270 --LLSPLIWCHNMVTLGWAVRFMVG--------RTGTACGTDPQAPNESLLTVDGLSNASCASVF 324

  Fly   344 VLVYYFLTAGMVWFVFLTYAWHW-------RAMGHV--------------------QDRIDKKGS 381
            ::.|||..|...|:..|...||.       .:.|||                    ||.  .:.:
  Fly   325 LMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDL--TQNN 387

  Fly   382 YFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRA--GLLLGPL-C-----GVILIG 438
            :...|||.||...|...:....||.:.::|.||||  |.|.:|  .|:..|: |     .:.||.
  Fly   388 FVCFVAWGLPAFQTSAVIVARFVDADELLGACFVG--NQSDKALQILVATPVFCYWIFGSMNLIS 450

  Fly   439 GYFI---TRGMVMLFGLKHFANDIKSTSA--SNKIHLIIMRMGV-CALLTLVFILVAIACHVTEF 497
            ||.:   |:.::...........::..||  |:.|.:.:...|: ||:|.|..|.        ||
  Fly   451 GYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIY--------EF 507

  Fly   498 RHADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSS---GIVMSTWCWTPSS 559
            .:.|.|..|                   ...|.|    |...||..|..   ||....|...||.
  Fly   508 ANIDVWLGS-------------------GDTNTP----LWPFLLRAFMELMLGICCFAWVLGPSI 549

  Fly   560 IETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSITLYNTHTDPVGLNFDVNDL 624
            ...:||.         |...||.||                                        
  Fly   550 STLYKRQ---------VSNGKMVKH---------------------------------------- 565

  Fly   625 NSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPRKNSLDSEISVSVRHVSVESRRNSV- 688
                                    ...|||||:...|...:.|..:..|..|.:.||.:...|| 
  Fly   566 ------------------------TSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVP 606

  Fly   689 -----------DSQVSVKIAEMKTKVASRS---RGKHGGSSSNRRTQRRRDYIAAATGKSSRRRE 739
                       ....|:.:.:|......||   :.:|.....:.:.|:...:     ......:.
  Fly   607 LPPSPYKLKTSPGTGSISLNQMSNYSLGRSVHHQQRHSPHHHHHQQQQHHQF-----HPHHNHQH 666

  Fly   740 SSTSVESQVIALKKTTYPNASHKVGVFAHHSSKKQH 775
            .|||..       :..||..|:....::.|.|...|
  Fly   667 HSTSSH-------RLYYPPGSYASQKYSQHGSYYPH 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 33/141 (23%)
7tmF_SMO_homolog 245..568 CDD:320158 88/394 (22%)
TM helix 1 254..279 CDD:320158 5/34 (15%)
TM helix 2 289..310 CDD:320158 3/20 (15%)
TM helix 3 340..366 CDD:320158 8/25 (32%)
TM helix 4 382..398 CDD:320158 6/15 (40%)
TM helix 5 420..449 CDD:320158 10/39 (26%)
TM helix 6 471..498 CDD:320158 7/27 (26%)
TM helix 7 529..554 CDD:320158 8/27 (30%)
fz4NP_511068.2 CRD_FZ4 43..169 CDD:143557 35/152 (23%)
7tmF_Frizzled_SMO 222..557 CDD:320089 88/402 (22%)
TM helix 1 231..256 CDD:320089 4/24 (17%)
TM helix 2 268..289 CDD:320089 3/27 (11%)
TM helix 3 321..347 CDD:320089 8/25 (32%)
TM helix 4 388..404 CDD:320089 6/15 (40%)
TM helix 5 426..455 CDD:320089 8/28 (29%)
TM helix 6 481..508 CDD:320089 9/34 (26%)
TM helix 7 519..544 CDD:320089 8/28 (29%)

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