DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and fz3

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_001096859.1	Gene:	fz3 / 31023	FlyBaseID:	FBgn0027343	Length:	646	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	101/484 - (20%)
Similarity:	173/484 - (35%)	Gaps:	120/484 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 PKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFFPKFLRCNETLFPT 201
            |.|...: |...|..|..||.:.||.|...|...|              ..:|.||.|:....|.
  Fly   164 PLCTPDV-PRPVAACKLLCETVRGECMENAPPELM--------------ELWPSFLNCDGLPQPE 213

  Fly   202 K---C------------------TNGARGMK------------FNGTGQCLSPLVPTDTSAS-YY 232
            |   |                  |.|:.|::            .:.|......|.|.:.|.| :.
  Fly   214 KHELCMQIPQEVAVPGGSPSGPPTTGSPGVEDHPQTYRFWKSGASPTSDLAGVLCPQNFSGSPFN 278

  Fly   233 PGIEGCGVRC-KDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANK--YPAVIVFY 294
            |  |.|..:| :|..:|..:.:....||....::|.:..||.:.||   |....:  ||...|.:
  Fly   279 P--EECVPQCQRDAFHTSSQKKTSETLILGLSAVCFVLTLFALVTF---WAEPTRFGYPERPVLF 338

  Fly   295 INLCFLIACVGWLLQFTSGSREDIVCRKDGTLRHSE-------PTAGENLSCIVIFVLVYYF-LT 351
            :.||:.:..|.:|        |.||......:...|       |.......|:..::...|. |.
  Fly   339 LCLCYNLFSVCYL--------ERIVFHNQARMHDVELQWRLMRPGCLLTPPCLASYITTSYLSLC 395

  Fly   352 AGMVWFVF-----LTYAWHWRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVG 411
            |...|.:|     |:....|.:     :.::|:...||::||..||...|..:...:|..:.:.|
  Fly   396 AASWWLIFALCFYLSSHKKWSS-----EALEKRSGLFHVLAWVPPLAPPIAALLLEKVRPSELTG 455

  Fly   412 ICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMG 476
            :|:.        .|.:..|...::|:|.||..|....|..|:   ..::.|.|.::...|..|.
  Fly   456 MCYA--------PGFVELPALVLLLLGLYFTLRASRSLLSLQ---QQLQPTLAHHRFGQIRKRF- 508

  Fly   477 VCALLTLVFI------LVAIACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGV 535
              .|.:|::.      :||..|.    |:||.         :...|:..:..|...:...|::..
  Fly   509 --VLFSLLYFAPTTAGVVAALCE----RYADS---------VPSCSTPDDCLSPTPLSAWPALVR 558

  Fly   536 LQLHLLCLFSSGIVMSTWCWTPSSIETWK 564
            :...|:    .|.:...|.|:..:.|:::
  Fly   559 IFFQLV----GGTLTGLWVWSRKTCESYR 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	23/116 (20%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	69/340 (20%)
fz3	NP_001096859.1	RRM	<19..>122	CDD:223796
		RRM_1	22..83	CDD:278504
		CRD_FZ	<138..224	CDD:295308	19/74 (26%)
		Frizzled	291..584	CDD:279827	69/340 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438641
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850