DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and Sfrp5

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_001101061.1	Gene:	Sfrp5 / 309377	RGDID:	1310369	Length:	314	Species:	Rattus norvegicus

Alignment Length:	168	Identity:	39/168 - (23%)
Similarity:	61/168 - (36%)	Gaps:	45/168 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PASAQQSDV---ELEPINGTLNYRLYAKKGRDDKPWFDGLDSRHIQCVRRARCYPTSNATNTCFG 102
            ||..|:.|.   :.||::|    |.|:|..               ||:......|..:..    |
  Rat    23 PARGQEYDYYGWQTEPLHG----RSYSKPP---------------QCLDIPADLPLCHTV----G 64

  Fly   103 SK---LPYELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMV 164
            .|   ||      :|.:..:..|:..:.:.:..|. ..:|.:..|.|||::|.|.|     .|..
  Rat    65 YKRMRLP------NLLEHESLAEVKQQASSWLPLL-AKRCHSDTQVFLCSLFAPVC-----LDRP 117

  Fly   165 YLPSYEMCRITMEPCRILYNTTFF--PKFLRCNETLFP 200
            ..|...:|......|..|.....|  |:.|.|::  ||
  Rat   118 IYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHK--FP 153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	27/120 (23%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827
Sfrp5	NP_001101061.1	CRD_SFRP5	44..170	CDD:143553	31/143 (22%)
Sfrp5	NP_001101061.1	NTR_Sfrp1_like	175..300	CDD:239635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900