DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and fzd7b

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_739569.1	Gene:	fzd7b / 30412	ZFINID:	ZDB-GENE-990415-229	Length:	557	Species:	Danio rerio

Alignment Length:	521	Identity:	135/521 - (25%)
Similarity:	227/521 - (43%)	Gaps:	111/521 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 HTEKE-LNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRI 181
            ||.:| ...:::.:|.|..| :|...::.|||:::.|.|..:   :....|...:|....:.|..
Zfish    69 HTNQEDAGLEVHQFYPLVKV-QCSQDLKFFLCSMYAPVCTVL---EQAIPPCRTLCERARQGCEA 129

  Fly   182 LYNTTFF--PKFLRCNETLFPTKCTNGARGMKFNGTGQ-CL-----SPLVPTDTSASYYP----- 233
            |.|...|  |:.|||..  ||.           :|.|: |:     .|.|||.....|.|
Zfish   130 LMNKFGFQWPERLRCEN--FPV-----------HGAGEICVGQNKSDPDVPTTNPTPYIPEPFSP 181

  Fly   234 ----------------------------GIEGCGVRC--KDP---LYTDDEHRQIHKLIGWAG-- 263
                                        |.:.||..|  |.|   :|..:|..:..:|  |.|
Zfish   182 RIHTPRQNQAFTCPLQLTVPSYLNYHFLGAKNCGAPCEHKQPYGLMYFKEEEVRFGRL--WVGIW 244

  Fly   264 -SICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACV----GWLLQFTSGSREDIVC--- 320
             .:|.:|.||.|.|:.:|.:..: ||...:.:::.|:.:..|    |:||:      :.:||
Zfish   245 SILCCVSTLFTVLTYLVDMRRFH-YPERPIIFLSGCYFMVAVAYAAGFLLE------DKVVCIDK 302

  Fly   321 -RKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGS 381
             |.|.....::.|..|  .|.::|:::|:|..|..:|:|.|:..|...|   .||  :.|:....
Zfish   303 FRDDAFKTVAQGTKKE--GCTILFMVLYFFGMASSIWWVILSLTWFLSAGMKWGH--EAIEANSQ 363

  Fly   382 YFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGM 446
            ||||.||::|.|.|||.:|..:|||:.:.|:|:||..|.....|.:|.||...:.||..|:..|.
Zfish   364 YFHLAAWAVPAVKTITILALGQVDGDLLTGVCYVGIYNVDALRGFVLAPLFVYLFIGTSFLLAGF 428

  Fly   447 VMLFG----LKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSF 507
            |.||.    :||      ..:.:.|:..:::|:||.::|..|...:.|||:..|....::|.:::
Zfish   429 VSLFRIRTIMKH------DGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTW 487

  Fly   508 RQFIICKISSVFEEKSSCRIEN----RPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIR 568
             ....||..:|     .|...|    .|...|..:..|.....||....|.|:..::::|:|:.:
Zfish   488 -HMQTCKRFAV-----PCPNNNFAPMTPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYK 546

  Fly   569 K 569
            :
Zfish   547 R 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	27/111 (24%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	96/343 (28%)
fzd7b	NP_739569.1	CRD_FZ1_like	43..161	CDD:143567	27/108 (25%)
fzd7b	NP_739569.1	Frizzled	228..545	CDD:279827	96/341 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810