DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and fzd2

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_571215.1	Gene:	fzd2 / 30370	ZFINID:	ZDB-GENE-990415-224	Length:	550	Species:	Danio rerio

Alignment Length:	516	Identity:	130/516 - (25%)
Similarity:	228/516 - (44%)	Gaps:	95/516 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 DLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITME 177
            :|...:.:::...:::.:|.|..| :|...::.|||:::.|.|..:   :....|...:|....:
Zfish    59 NLVGHYNQEDAGLEVHQFYPLVKV-QCSPELKFFLCSMYAPVCTVL---EKAIPPCRSICERAKQ 119

  Fly   178 PCRILYNTTFF--PKFLRCNETLFP-------------TKCTNGARGMKFNGTG----------- 216
            .|.:|.|...|  |:.|||..  ||             :..|.....|...||.
Zfish   120 GCEVLMNKFGFQWPEALRCEH--FPVLGDGHICVGQNDSMATVSPVHMPIPGTPSVQLYSTPDKP 182

  Fly   217 -QCLSPL-VPTDTSASYYPGIEGCGVRCKDP-------LYTDD--EHRQIHKLIGWAGSICLLSN 270
             :|.|.| ||...|..:. |...||..|:..       .:||.  |..:|..|| |: |:|..|.
Zfish   183 FRCPSTLKVPAYLSYKFL-GEPDCGAPCESSRTHRAYMFFTDQEIEFARIWILI-WS-SLCCAST 244

  Fly   271 LFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRK-----------DG 324
            ||.|:|:.:|.:.. |||...:.:::.|:.:..:.::..:..|.:  :||.:           .|
Zfish   245 LFTVTTYIVDMQRF-KYPERPIIFLSGCYTMVSIAYIAGYFLGDK--VVCNESFFPDSYKTIVQG 306

  Fly   325 TLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGSYFHLV 386
            |.:.         .|.::|:::|:|..|..:|:|.|:..|...|   .||  :.|:....||||.
Zfish   307 TKKE---------GCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGH--EAIEANSQYFHLA 360

  Fly   387 AWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFG 451
            ||::|.|.||:.:|..::||:.:.|:||||..|.....|.:|.||...:.||..|:..|.|.||.
Zfish   361 AWAVPAVKTISILAMGQIDGDVLSGVCFVGLNNSDALRGFILAPLFLYLFIGTSFLLAGFVSLFR 425

  Fly   452 ----LKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFII 512
                :||      ..:.:.|:..:::|:||.::|..|...:.|||...|.....:|.:|:.. :.
Zfish   426 IRTIMKH------DGTKTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFRQQWEKSWIS-MN 483

  Fly   513 CKISSVFEEKSSCRIENRPSV----GVLQLHLLCLFSSGIVMSTWCWTPSSIETWKR-YIR 568
            ||..::     .|.::..|.:    .|..:..|.....||....|.|:..::.:|:: |:|
Zfish   484 CKSLAI-----PCPMQPAPHMTPDFTVFMIKYLMTLIVGITSGFWIWSGKTLHSWQKFYVR 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	27/134 (20%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	93/346 (27%)
fzd2	NP_571215.1	CRD_FZ1_like	37..154	CDD:143567	22/100 (22%)
		7tmF_FZD2	219..548	CDD:320373	94/349 (27%)
		TM helix 1	228..253	CDD:320373	11/26 (42%)
		TM helix 2	262..283	CDD:320373	1/20 (5%)
		TM helix 3	313..339	CDD:320373	8/25 (32%)
		TM helix 4	356..372	CDD:320373	10/15 (67%)
		TM helix 5	394..423	CDD:320373	9/28 (32%)
		TM helix 6	443..470	CDD:320373	9/26 (35%)
		TM helix 7	499..524	CDD:320373	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810