Protein Alignment smo and fzd7a

DIOPT Version :9

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_571214.2
• Gene: fzd7a / 30369
• ZFINID: ZDB-GENE-990415-223
• Length: 559
• Species: Danio rerio
• Alignment Length: 518
• Identity: 129/518 - (24%)
• Similarity: 222/518 - (42%)
• Gaps: 104/518 - (20%)

  Fly   118 HTEKE-LNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRI 181
            ||.:| ...:::.:|.|..| :|...::.|||:::.|.|..:   :....|...:|....:.|..
Zfish    69 HTNQEDAGLEVHQFYPLVKV-QCSMDLKFFLCSMYAPVCTVL---EQAIPPCRSLCERARQGCEA 129

  Fly   182 LYNTTFF--PKFLRCNETLFPTKCTNGARGMKFNGTGQ-CLSPLV-----PTDTSASYYP----- 233
            |.|...|  |:.|||..  ||.           :|.|: |:....     ||.....|.|
Zfish   130 LMNKFGFQWPERLRCEN--FPV-----------HGAGEICVGQNTSDAGSPTSNPTPYVPELITL 181

  Fly   234 -----------------------------GIEGCGVRCKDP-----LYTDDEHRQIHKLIGWAG- 263
                                         |.:.||..|:..     :|..:|..:..:|  |.|
Zfish   182 QPNLVVRPNQQFTCPLQLKVPTYLKYHFMGEKDCGAPCEPTRPNGLMYFREEEVKFGRL--WVGI 244

  Fly   264 --SICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVC----RK 322
              .:|.:|.||.|.|:.:|.:.. :||...:.:::.|:.:..|.:...|.  ..:.:||    ..
Zfish   245 WSILCCVSTLFTVLTYLVDMRRF-RYPERPIIFLSGCYFMVAVAYAAGFF--LEDKVVCIDKFSD 306

  Fly   323 DGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGSYFH 384
            ||....::.|..|  .|.::|:::|:|..|..:|:|.|:..|...|   .||  :.|:....|||
Zfish   307 DGYKTVAQGTKKE--GCTILFMILYFFGMASSIWWVILSLTWFLSAGMKWGH--EAIEANSQYFH 367

  Fly   385 LVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVML 449
            |.||::|.|.|||.:|..:|||:.:.|:|:||..|.....|.:|.||...:.||..|:..|.|.|
Zfish   368 LAAWAVPAVKTITILAMGQVDGDMLTGVCYVGIYNVDSLRGFVLAPLFVYLFIGTSFLLAGFVSL 432

  Fly   450 FG----LKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQF 510
            |.    :||      ..:.:.|:..:::|:||.::|..|...:.|||:..|....::|.::: ..
Zfish   433 FRIRTIMKH------DGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTW-HM 490

  Fly   511 IICKISSVFEEKSSCRIEN----RPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRK 569
            ..||..:|     .|.:.|    .|...|..:..|.....||....|.|:..::::|:|:.::
Zfish   491 QTCKRFAV-----PCPVNNFAPMSPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKR 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	27/106 (25%)
		Frizzled	246..568	CDD:279827	94/339 (28%)
fzd7a	NP_571214.2	CRD_FZ	41..163	CDD:382974	27/110 (25%)
		7tm_GPCRs	228..558	CDD:391938	94/342 (27%)
		TM helix 1	238..262	CDD:341315	9/25 (36%)
		TM helix 2	271..292	CDD:341315	2/20 (10%)
		TM helix 3	322..344	CDD:341315	7/21 (33%)
		TM helix 4	365..381	CDD:341315	10/15 (67%)
		TM helix 5	403..426	CDD:341315	7/22 (32%)
		TM helix 6	454..479	CDD:341315	9/24 (38%)
		TM helix 7	508..533	CDD:341315	5/24 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810