Protein Alignment smo and fzd10

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_570992.2
• Gene: fzd10 / 30366
• ZFINID: ZDB-GENE-990415-220
• Length: 580
• Species: Danio rerio
• Alignment Length: 534
• Identity: 126/534 - (23%)
• Similarity: 226/534 - (42%)
• Gaps: 106/534 - (19%)

  Fly   107 YELSSL-DLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSY 169
            |.|:.: :|.....:.|...||:::..|... .|.:.::.|||:::.|.| |:::    ..:|:
Zfish    48 YNLTVMPNLMGHEDQNEAAIKLHEFAPLIEF-GCHSHLKFFLCSLYAPMCTEQVS----TPIPA- 106

  Fly   170 EMCRITMEPCR-----ILYNTTF-FPKFLRCNETLFPTK------CTNGARGMKFNGTGQ----- 217
              ||:..|..|     |:....| :|:.|.|:.  .|.|      |.....    |||.:
Zfish   107 --CRVMCEQARQKCSPIMEQFNFHWPESLDCSR--LPNKNDPNYLCMEAPN----NGTDEPPKGS 163

  Fly   218 ----------------------------CLSPLVPTDTSASYYPGIEGCGVRC---KDPLYTDDE 251
                                        |.:|     ....|....|.|..:|   .|..::..:
Zfish   164 HTQSPDSRPPRPGNSQELPIKERVGKTTCSNP-----GKFHYVQKSESCAPKCYSNVDVYWSQGD 223

  Fly   252 HRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSRE 316
            .|.....|.....:|.:|:.|.|.||.|| ....|||...:.::::.:.:..||:|::...|. |
Zfish   224 KRFSMVWIAIWSILCFISSAFTVLTFLID-PQRFKYPERPIIFLSMSYCVYSVGFLVRLFVGV-E 286

  Fly   317 DIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDK 378
            ::.|.:|..:::......|:..|.::|:::|||..|..:|:|.||..|...|   .||  :.|:.
Zfish   287 NVACDRDTGVQYIIQEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGH--EAIEA 349

  Fly   379 KGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFIT 443
            ..|||||.||::|.:.||..:...:|.|:.:.|:|:||.::.....|.:|.||...::||..|:.
Zfish   350 NSSYFHLAAWAIPAIKTIMILVMRKVAGDELTGVCYVGSMDVKALTGFVLIPLSCYLIIGTSFLL 414

  Fly   444 RGMVMLFGLKHFANDIKSTSASN--KIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQS 506
            .|.|.||.::    .:..|...|  |:..:::|:||.::|..|.....|||:..|..:.|.|
Zfish   415 SGFVALFHIR----KVMKTEGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYW--- 472

  Fly   507 FRQFIICKISSVFEEKSSCRIENR-----------PSVGVLQLHLLCLFSSGIVMSTWCWTPSSI 560
                      .:...:..|..:.:           |:|.:..:.:..|...||....|.||..::
Zfish   473 ----------KILAGEQKCADDGKSGEECVMKSSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTL 527

  Fly   561 ETWKRYIRKKCGKE 574
            ::|:....:|..|:
Zfish   528 QSWQNVFSRKLKKK 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	31/160 (19%)
		7tmF_SMO_homolog	245..568	CDD:320158	87/338 (26%)
		TM helix 1	254..279	CDD:320158	7/24 (29%)
		TM helix 2	289..310	CDD:320158	3/20 (15%)
		TM helix 3	340..366	CDD:320158	10/25 (40%)
		TM helix 4	382..398	CDD:320158	9/15 (60%)
		TM helix 5	420..449	CDD:320158	9/28 (32%)
		TM helix 6	471..498	CDD:320158	9/26 (35%)
		TM helix 7	529..554	CDD:320158	5/35 (14%)
fzd10	NP_570992.2	CRD_FZ	31..157	CDD:470581	29/122 (24%)
		7tmF_FZD10	217..535	CDD:320165	87/338 (26%)
		TM helix 1	226..251	CDD:320165	7/24 (29%)
		TM helix 2	260..281	CDD:320165	3/20 (15%)
		TM helix 3	310..336	CDD:320165	10/25 (40%)
		TM helix 4	353..369	CDD:320165	9/15 (60%)
		TM helix 5	391..420	CDD:320165	9/28 (32%)
		TM helix 6	440..467	CDD:320165	9/26 (35%)
		TM helix 7	496..521	CDD:320165	5/24 (21%)