Protein Alignment smo and fzd5

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_571209.2
• Gene: fzd5 / 30364
• ZFINID: ZDB-GENE-990415-218
• Length: 592
• Species: Danio rerio
• Alignment Length: 507
• Identity: 131/507 - (25%)
• Similarity: 220/507 - (43%)
• Gaps: 88/507 - (17%)

  Fly   120 EKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEM----CRITME--- 177
            :.|:..:::.::.|..: .|...:..|||:::.|.|          |..|:.    ||...|
Zfish    72 QDEVGLEVHQFWPLVRI-HCSPDLLFFLCSMYTPIC----------LQDYKKPLPPCRSVCERAK 125

  Fly   178 ----PCRILYNTTFFPKFLRCNE--------------------TL---FPTKCTNG--------- 206
                |..|.|... :|:.:.|.:                    ||   ||.....|
Zfish   126 RGCSPLMIQYGFE-WPERMSCEQLPMLGDTDRLCMDRNSSETTTLSPPFPKPTPKGTPRHRATAK 189

  Fly   207 -ARGMKFNGTGQCLSPLVPTDTSASYYP--------GIEGCGVRCKDPLYTDDEHRQIHKLIGWA 262
             |...|.:....|..||||....|  :|        .:..|.:.|..|.::.||.......||..
Zfish   190 SAPPQKCDRECHCRGPLVPIKKEA--HPLHNRVNTGSLPNCALPCHQPYFSQDERTFTTFWIGLW 252

  Fly   263 GSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLR 327
            ..:|.:|....|:||.||.:.. |||...:.::..|:|...:|::::..:| .|.:.|...|..:
Zfish   253 SVLCFVSTFTTVATFLIDMERF-KYPERPIIFLAACYLFVSLGYIVRLLAG-HERVACEGTGDQQ 315

  Fly   328 H-SEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA-MGHVQDRIDKKGSYFHLVAWSL 390
            | ...|.|..| |.::|:|:|:|..|..:|:|.|::.|...| |....:.|.....||||.||.:
Zfish   316 HILYDTTGPAL-CTLVFLLIYFFGMASSIWWVVLSFTWFLAAGMKWGNEAIAGYSQYFHLAAWLV 379

  Fly   391 PLVLTITTMAFSEVDGNSIVGICFVGYINHSMRA--GLLLGPLCGVILIGGYFITRGMVMLFGLK 453
            |.|.:|..:|.|.|||:.:.|||:||  |.|:..  |.:|.||...:..|..|:..|.|.||.::
Zfish   380 PSVKSIAVLALSSVDGDPVAGICYVG--NQSLEGLRGFVLAPLVVYLFTGSLFLLAGFVSLFRIR 442

  Fly   454 HFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSV 518
            ....  :..:.::|:..:::|:|:..:|..|...:.:||.|.|..:...|.::    :.|...|
Zfish   443 SVIK--QGGTKTDKLEKLMIRIGLFTVLYTVPATIVVACLVYEQHYRPSWERA----LACSCPS- 500

  Fly   519 FEEKSSCRIENRPSVGVLQL-HLLCLFSSGIVMSTWCWTPSSIETWKRYIRK 569
              |:.  |:...|...|..| :.:||. .||....|.|:..::|:|:|:|.:
Zfish   501 --ERQ--RLGMGPDYAVFMLKYFMCLV-VGITSGVWIWSGKTLESWRRFIAR 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	26/144 (18%)
		7tmF_SMO_homolog	245..568	CDD:320158	96/327 (29%)
		TM helix 1	254..279	CDD:320158	7/24 (29%)
		TM helix 2	289..310	CDD:320158	3/20 (15%)
		TM helix 3	340..366	CDD:320158	9/25 (36%)
		TM helix 4	382..398	CDD:320158	9/15 (60%)
		TM helix 5	420..449	CDD:320158	9/30 (30%)
		TM helix 6	471..498	CDD:320158	8/26 (31%)
		TM helix 7	529..554	CDD:320158	7/25 (28%)
fzd5	NP_571209.2	CRD_FZ5_like	44..163	CDD:143565	18/102 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..192		5/29 (17%)
		7tmF_FZD5	235..546	CDD:320377	96/327 (29%)
		TM helix 1	244..269	CDD:320377	7/24 (29%)
		TM helix 2	278..299	CDD:320377	3/20 (15%)
		TM helix 3	328..354	CDD:320377	9/25 (36%)
		TM helix 4	371..387	CDD:320377	9/15 (60%)
		TM helix 5	409..438	CDD:320377	8/28 (29%)
		TM helix 6	458..485	CDD:320377	8/26 (31%)
		TM helix 7	507..532	CDD:320377	7/25 (28%)