Protein Alignment smo and fzd4

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_001292398.1
• Gene: fzd4 / 30363
• ZFINID: ZDB-GENE-990415-217
• Length: 523
• Species: Danio rerio
• Alignment Length: 496
• Identity: 134/496 - (27%)
• Similarity: 217/496 - (43%)
• Gaps: 96/496 - (19%)

  Fly   139 CWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPC-RILYNTTF-FPKFLRCNETLFP 200
            |.:.::.|||:|:.|.| ||:   .:...|...||......| .:|....| :|:.|.|  :|||
Zfish    74 CSSQLKFFLCSVYVPMCTEKV---PIPIGPCGSMCMSVKRKCLPVLQEFGFVWPELLNC--SLFP 133

  Fly   201 TKCTNGARGMKFNGTG------QCLSPLVPTDTSA-SYYPGIE---------GCGVRCKDPLYTD 249
            .  ||....|...|.|      ..:.|:.|.:... :...|:|         .|.::|.   |..
Zfish   134 P--TNDQNHMCMEGPGDEDPPFHAVRPVAPQEEECIALGAGVEQYAWVKRSGSCSLQCG---YDT 193

  Fly   250 DEHRQIHKLIG------WAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLL 308
            ..:|:..|:..      || .:|.:|..|.|.||.:| .:...||...:.::::|..|..|.:::
Zfish   194 GLYRRQAKVFTDVWMAVWA-VLCFISTTFTVLTFLVD-SSRFSYPERPIIFLSMCCNIYSVAFIV 256

  Fly   309 QFTSGSREDIVCR----------KDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYA 363
            :.|.| ||.|.|.          ::|.         :|..|.::|:|.|:|..|..:|:|.||..
Zfish   257 RLTVG-RERISCDLEEAAVPVLVQEGL---------KNTGCAIVFLLTYFFGMASSIWWVILTLT 311

  Fly   364 WHWRA---MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAG 425
            |...|   .||  :.|:...||||:.||::|.|.||..:....||.:.:.|:|:||..|.....|
Zfish   312 WFLAAGLKWGH--EAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADDLAGMCYVGNQNLDALTG 374

  Fly   426 LLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAI 490
            .::.||...::||..||..|:|.||.::  :|..|..:.::|:..:::::||.::|..|.....|
Zfish   375 FVVAPLFTYLVIGTLFIAAGLVALFKIR--SNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVI 437

  Fly   491 ACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSS---GIVMST 552
            ||:   |.....|| .|||                  ..|.|  .:...:|.:|.|   ||....
Zfish   438 ACY---FYEISNWA-DFRQ------------------TARDS--YMAAEMLRIFMSLLVGITSGM 478

  Fly   553 WCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAK 593
            |.|:..::.||:|     |...:|...:..:.|..|..|.|
Zfish   479 WVWSAKTLHTWQR-----CSHRLVHTGRNNRVKRTANGWVK 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	26/90 (29%)
		7tmF_SMO_homolog	245..568	CDD:320158	96/344 (28%)
		TM helix 1	254..279	CDD:320158	9/30 (30%)
		TM helix 2	289..310	CDD:320158	3/20 (15%)
		TM helix 3	340..366	CDD:320158	10/25 (40%)
		TM helix 4	382..398	CDD:320158	9/15 (60%)
		TM helix 5	420..449	CDD:320158	9/28 (32%)
		TM helix 6	471..498	CDD:320158	7/26 (27%)
		TM helix 7	529..554	CDD:320158	7/27 (26%)
fzd4	NP_001292398.1	TM helix 7	455..480	CDD:320166	7/26 (27%)
		CRD_FZ4	26..150	CDD:143557	26/82 (32%)
		7tmF_FZD4	194..493	CDD:320166	95/343 (28%)
		TM helix 1	203..228	CDD:320166	8/25 (32%)
		TM helix 2	237..258	CDD:320166	3/20 (15%)
		TM helix 3	288..314	CDD:320166	10/25 (40%)
		TM helix 4	331..347	CDD:320166	9/15 (60%)
		TM helix 5	369..398	CDD:320166	9/28 (32%)
		TM helix 6	418..445	CDD:320166	8/29 (28%)