DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smo and smo

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_571102.2	Gene:	smo / 30225	ZFINID:	ZDB-GENE-980526-89	Length:	822	Species:	Danio rerio

Alignment Length:	794	Identity:	282/794 - (35%)
Similarity:	437/794 - (55%)	Gaps:	111/794 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 NTCFGSKLPYELSSLDLT-DFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGE 161
            |||.||.|||..:||.|. |..|::|..:||..:..|::.|:|||.|||.||||:.||||  ||:
Zfish    54 NTCLGSPLPYTHTSLILAEDSETQEEAFEKLAMWSGLRNAPRCWAVIQPLLCAVYMPKCE--NGK 116

  Fly   162 DMVYLPSYEMCRITMEPCRILYNTTFFPKFLRC-NETLFPTKCTNGARGMKFNGTGQCLSPLVPT 225
              |.|||..:|:.|..||.|:.....:|.||:| |:..||..|.|..:.:|||.:|||.:|||.|
Zfish   117 --VELPSQHLCQATRNPCSIVERERGWPNFLKCENKEQFPKGCQNEVQKLKFNTSGQCEAPLVKT 179

  Fly   226 DTSASYYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAV 290
            |..||:|..:||||::|.:||:|:|||..:|..|...|:|.||...|.::||..||||:|:||||
Zfish   180 DIQASWYKDVEGCGIQCDNPLFTEDEHSDMHSYIAVFGTITLLCTFFTLATFLADWKNSNRYPAV 244

  Fly   291 IVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMV 355
            |:||:|.||.|..:|||.||..|:|.:|||:.|.|:|..||::.|.|||::|||:|||.|.:|::
Zfish   245 ILFYVNACFFIGSIGWLAQFMDGARNEIVCKSDNTMRLGEPSSTETLSCVIIFVIVYYSLMSGVI 309

  Fly   356 WFVFLTYAWH--WRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYI 418
            |||.||||||  ::|:|.....:..|.||||||.||:|.:||:..:|.|:||.:|:.|||||||.
Zfish   310 WFVMLTYAWHTSFKALGTTHQPLSGKTSYFHLVTWSIPFILTVAILANSQVDADSVSGICFVGYR 374

  Fly   419 NHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTL 483
            .:..|||.:|.|:..|::|||||:.||::.||.:|.....:.|..|::||:..::|:|:...|..
Zfish   375 YYEYRAGFVLAPIGFVLVIGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAF 439

  Fly   484 VFILVAIACHVTEFRHADEWAQSFRQFIICKISSVFEEKSS-----CRIENRPSVGVLQLHLLCL 543
            .|:|:...||..:|.:..||.:|||::::|:.:.....:::     |.|:||||:.|.:::|..:
Zfish   440 GFVLITFGCHFYDFFNQAEWERSFREYVLCEANVTIAHQTNKPIPECAIKNRPSLLVGKINLFSM 504

  Fly   544 FSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDF--EDKGRLSIT 606
            |.:||.||||.||.::|..|||...:..|:...|..::.|.|:||:.::|||:.  :.:..||.:
Zfish   505 FGTGIAMSTWVWTKATILIWKRTWFRIIGRSDDEPKRIKKSKMIAKAFSKRKELQKDPEKELSFS 569

  Fly   607 LYN-THTDPV-GLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPRKNSLD 669
            ::. :|..|| |:|||:|:    .:.::||.||.::.:.|.||.|:                 |.
Zfish   570 MHTVSHEGPVAGINFDLNE----PSIEMSSAWAQHVTKMVARRGAI-----------------LP 613

  Fly   670 SEISVSVRHVSV--ESRRNS---VDSQVSVKIAEMKTKVASR------------------SRGKH 711
            .:|||:.....:  ...||.   |::::|.::.:.|.|...|                  .|.:.
Zfish   614 QDISVTPTGTPIPPPEERNKLWMVEAEISPEMMKRKKKKKKRRKEVRPAGPAADEGNPAYHRREF 678

  Fly   712 GGSS-------------------SNRRTQRRRDYIAAA----------------TGKSSRRRESS 741
            |.|:                   ..|:.|..:|.:..|                .|....|.:.|
Zfish   679 GPSAVPRLPKLPGHRSLVANLWEQQRQQQEEQDMLPGAFPEFRPSCPLPYQDRYGGLGYLRNKPS 743

  Fly   742 TSVESQVIALKKTTYPNASH-------KVGVFAH---HSSKKQHNYTSSMKRRTANAGLD----P 792
            :...:..:.|:.:...:.||       ..|||.|   .:|......|:.:.|.....|:.    .
Zfish   744 SLPLANPLTLRDSMQGDLSHFQQSSWQPKGVFRHLGQEASMMDVGRTAVVPRADGRRGVQIHSRT 808

  Fly   793 SILN-EFLQKNGDF 805
            :::: |.|..:.||
Zfish   809 NLMDAELLDADSDF 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	58/124 (47%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	147/328 (45%)
smo	NP_571102.2	CRD_SMO	44..175	CDD:143560	57/122 (47%)
smo	NP_571102.2	Frizzled	200..528	CDD:279827	148/334 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589245
Domainoid	1	1.000	327	1.000	Domainoid score	I1148
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4115
Inparanoid	1	1.050	501	1.000	Inparanoid score	I1328
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114070at33208
OrthoFinder	1	1.000	-	-		FOG0008402
OrthoInspector	1	1.000	-	-		oto40189
orthoMCL	1	0.900	-	-		OOG6_108731
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4761
SonicParanoid	1	1.000	-	-		X6393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790