Protein Alignment smo and Frzb

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_001093997.1
• Gene: Frzb / 295691
• RGDID: 1311315
• Length: 323
• Species: Rattus norvegicus
• Alignment Length: 258
• Identity: 55/258 - (21%)
• Similarity: 78/258 - (30%)
• Gaps: 102/258 - (39%)

  Fly     8 RMPNIMM-----FLEVAILCLWVVADASASSAKFGSTTPASAQQSDVELEPINGTLNYRLYAKKG 67
            |.|..|:     .|.:|.|||..|..|.|::.                 ||:...|...|
  Rat     4 RGPGRMLLGWAGLLVLAALCLLQVPGAQAAAC-----------------EPVRIPLCKSL----- 46

  Fly    68 RDDKPWFDGLDSRHIQCVRRARCYPTSNATNTCFGSKLPYELSSLDLTDFHTEKELNDKLNDYYA 132
                ||                     |.|      |:|..|        |...:.|..|    |
  Rat    47 ----PW---------------------NMT------KMPNHL--------HHSTQANAIL----A 68

  Fly   133 LKHV-----PKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMC---RITMEPCRILYNTTFFP 189
            ::..     ..|...:..||||::.|.| .|:.:.....|...:|   |...||..|.|..: :|
  Rat    69 IEQFEGLLGTHCSPDLLFFLCAMYAPIC-TIDFQHEPIKPCKSVCERARQGCEPILIKYRHS-WP 131

  Fly   190 KFLRCNETLFPTKCTNGARGMKFNGTGQCLSPLV---------PTDTSASYYPGIEGCGVRCK 243
            :.|.|.|             :.....|.|:||..         |.|:|..:..|......:||
  Rat   132 ESLACEE-------------LPVYDRGVCISPEAIVTADGADFPMDSSTGHCRGTSSERCKCK 181

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	30/142 (21%)
		7tmF_SMO_homolog	245..568	CDD:320158
		TM helix 1	254..279	CDD:320158
		TM helix 2	289..310	CDD:320158
		TM helix 3	340..366	CDD:320158
		TM helix 4	382..398	CDD:320158
		TM helix 5	420..449	CDD:320158
		TM helix 6	471..498	CDD:320158
		TM helix 7	529..554	CDD:320158
Frzb	NP_001093997.1	CRD_SFRP3	32..157	CDD:143550	39/204 (19%)
		NTR_Sfrp3_like	188..297	CDD:239636