DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smo and Corin

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_872279.2	Gene:	Corin / 289596	RGDID:	727887	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	868	Identity:	160/868 - (18%)
Similarity:	250/868 - (28%)	Gaps:	330/868 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NIMMFLEVAIL-CLWVVADASASSAKFGSTTPASAQQSDVELEP--------INGTLNYRLYAKK 66
            |::.||.:.:: |:..:....|....|..|......:|: :.||        :.|.::...|...
  Rat   109 NLLRFLLLVLIPCICALIVLLAILLSFVGTLKKVYFKSN-DSEPLVTDGEVRVPGVIHVNRYENT 172

  Fly    67 GRDDKP-------WFDGLDSRHIQCVRRARCYPTSNATNTCFG------SKLPYELSSLDL---- 114
            |....|       |.....|...|         :...|:||..      ..|||..:...|
  Rat   173 GAPSMPPSQSIPAWTPRAPSLEDQ---------SHGNTSTCVNITHRQCQILPYHSTLAPLLPIV 228

  Fly   115 TDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDM-VYLPSYEMCRITMEP 178
            .:..|||.|.     ::...|...|:..|..|.|::..||| .::|:|. ..||....|....|.
  Rat   229 KNMDTEKFLK-----FFTYLHRLGCYQHILLFGCSLAFPKC-IVDGDDRHGLLPCRSFCEAAKEG 287

  Fly   179 CRILYN--TTFFPKFLRCNETLFPTK-----------------------------CTNG---ARG 209
            |..:..  .:.:|..|||::..:.|:                             ||:|   ::.
  Rat   288 CESVLGMVNSSWPDSLRCSQFRYHTENNSDASRICFSLQQEHGKQSLCGGGESFLCTSGLCISKK 352

  Fly   210 MKFN-----------------------GTGQCLSPLVPTDTSASYYPGIEGCG------------ 239
            ::.|                       |||:||...:..|       |.:.||
  Rat   353 LQCNGYNDCDDWSDEAHCNCSEDLFHCGTGKCLHHSLVCD-------GYDDCGDLSDEQNCDCNL 410

  Fly   240 ---VRCKD------PLYTDDEHRQIHK------------LIGWAGSICLLSNLFVVSTFFIDW-- 281
               .||.|      ....|.:|..:.|            |:......|      :.|||..|.
  Rat   411 TKEHRCGDGRCIAAEWVCDGDHDCVDKSDEVNCSCPSQGLVECRSGQC------IPSTFQCDGDE 469

  Fly   282 --------KNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTL---RHSEPTAGE 335
                    :|.:..|.........|...:||    :..:||.   :|..|.:|   .|.||...|
  Rat   470 DCKDGSDEENCSDRPTPCPGGDRGCLDSSCV----ESCAGSS---LCDSDSSLSNCSHCEPITLE 527

  Fly   336 ---NLSCIVIFVLVYYFLTAGMVWFVFLTYAWHW-RAMGHVQDRIDKKGSYFHLVAWSLPLVLTI 396
               ||.         |.||             |: ..:||   |..|:.|    ::|...|...:
  Rat   528 LCMNLP---------YNLT-------------HYPNYLGH---RTQKEAS----ISWESALFPAL 563

  Fly   397 TTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKS 461
                   |..|....:.|.        |..:|.|.|.|                          :
  Rat   564 -------VQTNCYKYLMFF--------ACTILVPKCDV--------------------------N 587

  Fly   462 TSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFI--------ICKISSV 518
            |.         .|:..|.||          |     .|:.|..:|....:        .|   |.
  Rat   588 TG---------QRVPPCRLL----------C-----EHSKERCESVLGIVGLQWPEDTDC---SQ 625

  Fly   519 FEEKSS----CRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSI--------------ETWKR 565
            |.|:||    |.:.|.........|..|.....::.|..|...:..              :.|:.
  Rat   626 FPEQSSDNQTCLLPNEDVEECSPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGCKERDLWEC 690

  Fly   566 YIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLS------ITLYNTHTDPVGLNFDVNDL 624
            .:.|:|          .||.:|...:....|..|:...|      :...|....|..|..|
  Rat   691 PLNKQC----------LKHTLICDGFPDCSDSMDEKNCSFCQDDELECANHECVPRDLWCD---- 741

  Fly   625 NSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPRKNSLDSEISVSVRHVSVESRRNSVD 689
            ..::.:|.|..|.     ||      |.:..|||||.      |....|....||..:..:.::.
  Rat   742 GWTDCSDSSDEWG-----CV------TLSKNGNSSSF------LTVHRSARDHHVCADGWQETLS 789

  Fly   690 SQVSVKIAEMKTKVASRSRGKHG 712
            .....::...:..|....:|:.|
  Rat   790 QLACRQMGLGEPSVTELVQGQEG 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	40/202 (20%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	66/376 (18%)
Corin	NP_872279.2	DDNN motif	93..96
		CRD_corin_1	200..329	CDD:143554	31/134 (23%)
		LDLa	335..370	CDD:238060	4/34 (12%)
		LDLa	372..406	CDD:238060	9/40 (23%)
		Ldl_recept_a	413..443	CDD:395011	6/29 (21%)
		LDLa	453..480	CDD:238060	5/32 (16%)
		CRD_corin_2	521..641	CDD:143579	40/216 (19%)
		Ldl_recept_a	646..680	CDD:395011	4/33 (12%)
		LDLa	<693..718	CDD:238060	7/34 (21%)
		LDLa	721..755	CDD:238060	7/42 (17%)
		SRCR_2	779..859	CDD:413346	4/34 (12%)
		Tryp_SPc	867..1098	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810