DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment smo and Corin

DIOPT Version :10

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_872279.2 Gene:Corin / 289596 RGDID:727887 Length:1111 Species:Rattus norvegicus


Alignment Length:868 Identity:160/868 - (18%)
Similarity:250/868 - (28%) Gaps:330/868 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 NIMMFLEVAIL-CLWVVADASASSAKFGSTTPASAQQSDVELEP--------INGTLNYRLYAKK 66
            |::.||.:.:: |:..:....|....|..|......:|: :.||        :.|.::...|...
  Rat   109 NLLRFLLLVLIPCICALIVLLAILLSFVGTLKKVYFKSN-DSEPLVTDGEVRVPGVIHVNRYENT 172

  Fly    67 GRDDKP-------WFDGLDSRHIQCVRRARCYPTSNATNTCFG------SKLPYELSSLDL---- 114
            |....|       |.....|...|         :...|:||..      ..|||..:...|    
  Rat   173 GAPSMPPSQSIPAWTPRAPSLEDQ---------SHGNTSTCVNITHRQCQILPYHSTLAPLLPIV 228

  Fly   115 TDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDM-VYLPSYEMCRITMEP 178
            .:..|||.|.     ::...|...|:..|..|.|::..||| .::|:|. ..||....|....|.
  Rat   229 KNMDTEKFLK-----FFTYLHRLGCYQHILLFGCSLAFPKC-IVDGDDRHGLLPCRSFCEAAKEG 287

  Fly   179 CRILYN--TTFFPKFLRCNETLFPTK-----------------------------CTNG---ARG 209
            |..:..  .:.:|..|||::..:.|:                             ||:|   ::.
  Rat   288 CESVLGMVNSSWPDSLRCSQFRYHTENNSDASRICFSLQQEHGKQSLCGGGESFLCTSGLCISKK 352

  Fly   210 MKFN-----------------------GTGQCLSPLVPTDTSASYYPGIEGCG------------ 239
            ::.|                       |||:||...:..|       |.:.||            
  Rat   353 LQCNGYNDCDDWSDEAHCNCSEDLFHCGTGKCLHHSLVCD-------GYDDCGDLSDEQNCDCNL 410

  Fly   240 ---VRCKD------PLYTDDEHRQIHK------------LIGWAGSICLLSNLFVVSTFFIDW-- 281
               .||.|      ....|.:|..:.|            |:......|      :.|||..|.  
  Rat   411 TKEHRCGDGRCIAAEWVCDGDHDCVDKSDEVNCSCPSQGLVECRSGQC------IPSTFQCDGDE 469

  Fly   282 --------KNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTL---RHSEPTAGE 335
                    :|.:..|.........|...:||    :..:||.   :|..|.:|   .|.||...|
  Rat   470 DCKDGSDEENCSDRPTPCPGGDRGCLDSSCV----ESCAGSS---LCDSDSSLSNCSHCEPITLE 527

  Fly   336 ---NLSCIVIFVLVYYFLTAGMVWFVFLTYAWHW-RAMGHVQDRIDKKGSYFHLVAWSLPLVLTI 396
               ||.         |.||             |: ..:||   |..|:.|    ::|...|...:
  Rat   528 LCMNLP---------YNLT-------------HYPNYLGH---RTQKEAS----ISWESALFPAL 563

  Fly   397 TTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKS 461
                   |..|....:.|.        |..:|.|.|.|                          :
  Rat   564 -------VQTNCYKYLMFF--------ACTILVPKCDV--------------------------N 587

  Fly   462 TSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFI--------ICKISSV 518
            |.         .|:..|.||          |     .|:.|..:|....:        .|   |.
  Rat   588 TG---------QRVPPCRLL----------C-----EHSKERCESVLGIVGLQWPEDTDC---SQ 625

  Fly   519 FEEKSS----CRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTPSSI--------------ETWKR 565
            |.|:||    |.:.|.........|..|.....::.|..|...:..              :.|:.
  Rat   626 FPEQSSDNQTCLLPNEDVEECSPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGCKERDLWEC 690

  Fly   566 YIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLS------ITLYNTHTDPVGLNFDVNDL 624
            .:.|:|          .||.:|...:....|..|:...|      :...|....|..|..|    
  Rat   691 PLNKQC----------LKHTLICDGFPDCSDSMDEKNCSFCQDDELECANHECVPRDLWCD---- 741

  Fly   625 NSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPRKNSLDSEISVSVRHVSVESRRNSVD 689
            ..::.:|.|..|.     ||      |.:..|||||.      |....|....||..:..:.::.
  Rat   742 GWTDCSDSSDEWG-----CV------TLSKNGNSSSF------LTVHRSARDHHVCADGWQETLS 789

  Fly   690 SQVSVKIAEMKTKVASRSRGKHG 712
            .....::...:..|....:|:.|
  Rat   790 QLACRQMGLGEPSVTELVQGQEG 812

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 40/202 (20%)
7tmF_SMO_homolog 245..568 CDD:320158 66/377 (18%)
TM helix 1 254..279 CDD:320158 6/36 (17%)
TM helix 2 289..310 CDD:320158 3/20 (15%)
TM helix 3 340..366 CDD:320158 3/25 (12%)
TM helix 4 382..398 CDD:320158 2/15 (13%)
TM helix 5 420..449 CDD:320158 5/28 (18%)
TM helix 6 471..498 CDD:320158 5/26 (19%)
TM helix 7 529..554 CDD:320158 4/24 (17%)
CorinNP_872279.2 DDNN motif 93..96
CRD_corin_1 200..329 CDD:143554 31/134 (23%)
LDLa 335..370 CDD:238060 4/34 (12%)
LDLa 372..406 CDD:238060 9/40 (23%)
Ldl_recept_a 413..443 CDD:395011 6/29 (21%)
LDLa 453..480 CDD:238060 5/32 (16%)
CRD_corin_2 521..641 CDD:143579 40/216 (19%)
Ldl_recept_a 646..680 CDD:395011 4/33 (12%)
LDLa <693..718 CDD:238060 7/34 (21%)
LDLa 721..755 CDD:238060 7/42 (17%)
SR 756..851 CDD:214555 14/69 (20%)
Tryp_SPc 867..1098 CDD:238113
Blue background indicates that the domain is not in the aligned region.

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