DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smo and Fzd6

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_001124008.1	Gene:	Fzd6 / 282581	RGDID:	628816	Length:	710	Species:	Rattus norvegicus

Alignment Length:	700	Identity:	149/700 - (21%)
Similarity:	268/700 - (38%)	Gaps:	162/700 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 KCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPCRILYNT--TFFPKFLRCN---- 195
            :|...|:.|||..|.|.| |:|:    |..|..::|...:..|:.|.:|  ..:|:.|.|:
  Rat    68 ECSPNIEMFLCQAFVPTCTEQID----VVSPCRKLCEKILSDCQKLMDTFGIRWPEELECHRLPY 128

  Fly   196 -------------ETLFPTK------------C-----TNGARGMKFNGTGQCLSPLVPTDTSAS 230
                         |...|.|            |     |:|.:|.:|.|..||..|
  Rat   129 CDGAVPVTSDPHTELFGPQKKTDQVPRDIGFWCPKHLRTSGDQGYRFLGIDQCAPP--------- 184

  Fly   231 YYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYI 295
                       |.:..:..||.......||.....||.:.||...||.||.:.. :||...:.|.
  Rat   185 -----------CPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRF-RYPERPIIYY 237

  Fly   296 NLCFLIACVGWLLQFTSGSREDIVCRKDG---TLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWF 357
            ::|:.|..:.:.:.|..|:  ...|.|..   .|.::.....:|.:|.|:|:.:|:|..||.||:
  Rat   238 SVCYSIVSLMYFVGFLLGN--STACNKADEKLELGNTVVLGSKNKACSVVFMFLYFFTMAGTVWW 300

  Fly   358 VFLTYAW------HWRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVG 416
            |.||..|      .|..     :.|::|..:||.|||.:|..||:..:|.::|:|::|.|:||||
  Rat   301 VILTITWFLAAGRKWSC-----EAIEQKAVWFHAVAWGMPGFLTVMLLAMNKVEGDNISGVCFVG 360

  Fly   417 YINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSAS-NKIHLIIMRMGVCAL 480
            ..:.......:|.|||..:.:|...:..|::   .|.|....|:....: .|:...::|:||.:.
  Rat   361 LYDLDASRYFVLLPLCLCVFVGLSLLLAGII---SLNHVRQVIQHDGRNQEKLKKFMIRIGVFSG 422

  Fly   481 LTLVFILVAIACHVTEFRHADEWAQSF-----RQFIICKISSVFEEKSSCRIENRPSVGVLQLHL 540
            |.||.::..:.|:|.|..:...|..::     .|:   :|...::.....    ||.:.:..:..
  Rat   423 LYLVPLVTLLGCYVYELVNRVTWEMTWFSDHCHQY---RIPCPYQANPKA----RPELALFMIKY 480

  Fly   541 LCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSI 605
            |.....||....|..:..:...|..:.::...::.:.|    ..:|:.::.    :|..|....:
  Rat   481 LMTLIVGISAVFWVGSKKTCTEWAGFCKRNRKRDPISE----SRRVLQESC----EFFLKHNSKV 537

  Fly   606 TLYNTHTDPVGLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPRKNSLDS 670
            .....|..|          .|.:...||.:               .|.:||.::.||..
  Rat   538 RHKKKHGKP----------GSHKLKVISKS---------------MGTSTGVTTDHGTS------ 571

  Fly   671 EISVSVRHVSVESRRNSVDSQVSVKIAEMKTKVASR-------------------SRGKHGGSSS 716
              :|::.......:..|.:.|.|.: |.:|...|.|                   |..|..|...
  Rat   572 --AVAIADHDYLGQETSAEVQTSPE-ASLKEGRADRANTPRAKGPDCGEPASTAASNSKFSGDQI 633

  Fly   717 NRRTQ----RRRDYI---AAATGKSSRRRESSTSVESQVIALKKTTYPNA 759
            :|:::    :.:..:   |.:.|:.|.:....|.:....:.:..:..||:
  Rat   634 DRKSRAGSVKEKSSVSEGAPSEGRVSPKGVPGTGLMECTLQIPSSPEPNS 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	30/119 (25%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	85/336 (25%)
Fzd6	NP_001124008.1	CRD_FZ6	20..146	CDD:143559	20/81 (25%)
		7tmF_FZD6	188..508	CDD:320160	85/337 (25%)
		TM helix 1	198..222	CDD:320160	8/23 (35%)
		TM helix 2	231..252	CDD:320160	3/20 (15%)
		TM helix 3	283..305	CDD:320160	10/21 (48%)
		TM helix 4	326..342	CDD:320160	8/15 (53%)
		TM helix 5	364..387	CDD:320160	5/22 (23%)
		TM helix 6	418..440	CDD:320160	8/21 (38%)
		TM helix 7	469..494	CDD:320160	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810