Protein Alignment smo and Fzd6

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_001124008.1
• Gene: Fzd6 / 282581
• RGDID: 628816
• Length: 710
• Species: Rattus norvegicus
• Alignment Length: 700
• Identity: 149/700 - (21%)
• Similarity: 268/700 - (38%)
• Gaps: 162/700 - (23%)

  Fly   138 KCWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPCRILYNT--TFFPKFLRCN---- 195
            :|...|:.|||..|.|.| |:|:    |..|..::|...:..|:.|.:|  ..:|:.|.|:
  Rat    68 ECSPNIEMFLCQAFVPTCTEQID----VVSPCRKLCEKILSDCQKLMDTFGIRWPEELECHRLPY 128

  Fly   196 -------------ETLFPTK------------C-----TNGARGMKFNGTGQCLSPLVPTDTSAS 230
                         |...|.|            |     |:|.:|.:|.|..||..|
  Rat   129 CDGAVPVTSDPHTELFGPQKKTDQVPRDIGFWCPKHLRTSGDQGYRFLGIDQCAPP--------- 184

  Fly   231 YYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYI 295
                       |.:..:..||.......||.....||.:.||...||.||.:.. :||...:.|.
  Rat   185 -----------CPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRF-RYPERPIIYY 237

  Fly   296 NLCFLIACVGWLLQFTSGSREDIVCRKDG---TLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWF 357
            ::|:.|..:.:.:.|..|:  ...|.|..   .|.::.....:|.:|.|:|:.:|:|..||.||:
  Rat   238 SVCYSIVSLMYFVGFLLGN--STACNKADEKLELGNTVVLGSKNKACSVVFMFLYFFTMAGTVWW 300

  Fly   358 VFLTYAW------HWRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVG 416
            |.||..|      .|..     :.|::|..:||.|||.:|..||:..:|.::|:|::|.|:||||
  Rat   301 VILTITWFLAAGRKWSC-----EAIEQKAVWFHAVAWGMPGFLTVMLLAMNKVEGDNISGVCFVG 360

  Fly   417 YINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSAS-NKIHLIIMRMGVCAL 480
            ..:.......:|.|||..:.:|...:..|::   .|.|....|:....: .|:...::|:||.:.
  Rat   361 LYDLDASRYFVLLPLCLCVFVGLSLLLAGII---SLNHVRQVIQHDGRNQEKLKKFMIRIGVFSG 422

  Fly   481 LTLVFILVAIACHVTEFRHADEWAQSF-----RQFIICKISSVFEEKSSCRIENRPSVGVLQLHL 540
            |.||.::..:.|:|.|..:...|..::     .|:   :|...::.....    ||.:.:..:..
  Rat   423 LYLVPLVTLLGCYVYELVNRVTWEMTWFSDHCHQY---RIPCPYQANPKA----RPELALFMIKY 480

  Fly   541 LCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRKDFEDKGRLSI 605
            |.....||....|..:..:...|..:.::...::.:.|    ..:|:.::.    :|..|....:
  Rat   481 LMTLIVGISAVFWVGSKKTCTEWAGFCKRNRKRDPISE----SRRVLQESC----EFFLKHNSKV 537

  Fly   606 TLYNTHTDPVGLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATGNSSSHGPRKNSLDS 670
            .....|..|          .|.:...||.:               .|.:||.::.||..
  Rat   538 RHKKKHGKP----------GSHKLKVISKS---------------MGTSTGVTTDHGTS------ 571

  Fly   671 EISVSVRHVSVESRRNSVDSQVSVKIAEMKTKVASR-------------------SRGKHGGSSS 716
              :|::.......:..|.:.|.|.: |.:|...|.|                   |..|..|...
  Rat   572 --AVAIADHDYLGQETSAEVQTSPE-ASLKEGRADRANTPRAKGPDCGEPASTAASNSKFSGDQI 633

  Fly   717 NRRTQ----RRRDYI---AAATGKSSRRRESSTSVESQVIALKKTTYPNA 759
            :|:::    :.:..:   |.:.|:.|.:....|.:....:.:..:..||:
  Rat   634 DRKSRAGSVKEKSSVSEGAPSEGRVSPKGVPGTGLMECTLQIPSSPEPNS 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	30/119 (25%)
		7tmF_SMO_homolog	245..568	CDD:320158	85/337 (25%)
		TM helix 1	254..279	CDD:320158	8/24 (33%)
		TM helix 2	289..310	CDD:320158	3/20 (15%)
		TM helix 3	340..366	CDD:320158	12/31 (39%)
		TM helix 4	382..398	CDD:320158	8/15 (53%)
		TM helix 5	420..449	CDD:320158	6/28 (21%)
		TM helix 6	471..498	CDD:320158	9/26 (35%)
		TM helix 7	529..554	CDD:320158	5/24 (21%)
Fzd6	NP_001124008.1	CRD_FZ6	20..146	CDD:143559	20/81 (25%)
		7tmF_FZD6	188..508	CDD:320160	85/337 (25%)
		TM helix 1	197..222	CDD:320160	8/24 (33%)
		TM helix 2	231..252	CDD:320160	3/20 (15%)
		TM helix 3	283..309	CDD:320160	12/25 (48%)
		TM helix 4	326..342	CDD:320160	8/15 (53%)
		TM helix 5	364..393	CDD:320160	6/31 (19%)
		TM helix 6	413..440	CDD:320160	9/26 (35%)
		TM helix 7	469..494	CDD:320160	5/28 (18%)