DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and FZD2

DIOPT Version :10

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_001457.1 Gene:FZD2 / 2535 HGNCID:4040 Length:565 Species:Homo sapiens


Alignment Length:529 Identity:124/529 - (23%)
Similarity:216/529 - (40%) Gaps:120/529 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 HTEKE-LNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRI 181
            ||.:| ...:::.:|.|..| :|...::.|||:::.|.|..:   :....|...:|....:.|..
Human    63 HTNQEDAGLEVHQFYPLVKV-QCSPELRFFLCSMYAPVCTVL---EQAIPPCRSICERARQGCEA 123

  Fly   182 LYNTTFF--PKFLRCNE-------------------------TLFPTKCTNGARG---------- 209
            |.|...|  |:.|||..                         |..|.....||.|          
Human   124 LMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGA 188

  Fly   210 ------------------------MKFNGTGQCLSPLVPTDTSASYYPGIEGCGVRCKDPLYTDD 250
                                    .||.|...|.:|..|.....|.:              ::.:
Human   189 PPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMF--------------FSQE 239

  Fly   251 EHRQIHK-LIGWAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGS 314
            |.|.... ::.|: .:|..|..|.|:|:.:|.:.. :||...:.:::.|:.:..|.::..|.  .
Human   240 ETRFARLWILTWS-VLCCASTFFTVTTYLVDMQRF-RYPERPIIFLSGCYTMVSVAYIAGFV--L 300

  Fly   315 REDIVCR----KDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHV 372
            :|.:||.    :||.....:.|..|  .|.::|:::|:|..|..:|:|.|:..|...|   .|| 
Human   301 QERVVCNERFSEDGYRTVVQGTKKE--GCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGH- 362

  Fly   373 QDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILI 437
             :.|:....||||.||::|.|.|||.:|..::||:.:.|:||||..:.....|.:|.||...:.|
Human   363 -EAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFI 426

  Fly   438 GGYFITRGMVMLFG----LKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFR 498
            |..|:..|.|.||.    :||      ..:.:.|:..:::|:||.::|..|...:.|||:..|..
Human   427 GTSFLLAGFVSLFRIRTIMKH------DGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQA 485

  Fly   499 HADEWAQSF-RQFIICKISSV-----FEEKSSCRIENRPSVGVLQLHLLCLFSSGIVMSTWCWTP 557
            ..:.|.:|: .|.  ||..::     :..:.|      |...|..:..|.....||....|.|:.
Human   486 FREHWERSWVSQH--CKSLAIPCPAHYTPRMS------PDFTVYMIKYLMTLIVGITSGFWIWSG 542

  Fly   558 SSIETWKRY 566
            .::.:|:::
Human   543 KTLHSWRKF 551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 31/164 (19%)
7tmF_SMO_homolog 245..568 CDD:320158 90/340 (26%)
TM helix 1 254..279 CDD:320158 6/25 (24%)
TM helix 2 289..310 CDD:320158 2/20 (10%)
TM helix 3 340..366 CDD:320158 8/25 (32%)
TM helix 4 382..398 CDD:320158 10/15 (67%)
TM helix 5 420..449 CDD:320158 9/28 (32%)
TM helix 6 471..498 CDD:320158 9/26 (35%)
TM helix 7 529..554 CDD:320158 5/24 (21%)
FZD2NP_001457.1 CRD_FZ2 35..161 CDD:143573 22/101 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..189 5/28 (18%)
7tmF_FZD2 234..563 CDD:320373 90/354 (25%)
TM helix 1 243..268 CDD:320373 6/25 (24%)
TM helix 2 277..298 CDD:320373 2/20 (10%)
TM helix 3 328..354 CDD:320373 8/25 (32%)
TM helix 4 371..387 CDD:320373 10/15 (67%)
TM helix 5 409..438 CDD:320373 9/28 (32%)
TM helix 6 458..485 CDD:320373 9/26 (35%)
TM helix 7 514..539 CDD:320373 6/30 (20%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 543..548 0/4 (0%)
PDZ-binding 563..565
Blue background indicates that the domain is not in the aligned region.

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