DRSC/TRiP Functional Genomics Resources

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Protein Alignment smo and Smo

DIOPT Version :10

Sequence 1:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster
Sequence 2:NP_036939.2 Gene:Smo / 25273 RGDID:3726 Length:793 Species:Rattus norvegicus


Alignment Length:656 Identity:257/656 - (39%)
Similarity:396/656 - (60%) Gaps:55/656 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 CVRRARCYPTSNATNTCFGSKLPYELSSLDLT-DFHTEKELNDKLNDYYALKHVPKCWAAIQPFL 147
            |.|.|.|.|.  ..|.|.||.|||..::..|. |..:::|.:.||..:..|::.|:|||.|||.|
  Rat    68 CGRAAHCEPL--RYNVCLGSALPYGATTTLLAGDSDSQEEAHSKLVLWSGLRNAPRCWAVIQPLL 130

  Fly   148 CAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRILYNTTFFPKFLRCNETLFPTKCTNGARGMKF 212
            |||:.||||    .|.|.|||..:|:.|..||.|:.....:|.||||....||..|.|..:.:||
  Rat   131 CAVYMPKCE----NDRVELPSRTLCQATRGPCAIVERERGWPDFLRCMPDHFPEGCPNEVQNIKF 191

  Fly   213 NGTGQCLSPLVPTDTSASYYPGIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTF 277
            |.:|||.:|||.||...|:|..:||||::|::||:|:.||:.:|..|...|::..|..||.::||
  Rat   192 NSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATF 256

  Fly   278 FIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLRHSEPTAGENLSCIVI 342
            ..||:|:|:|||||:||:|.||.:..:|||.||..|:|.:||||.|||:|..|||:.|.|||::|
  Rat   257 VADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVII 321

  Fly   343 FVLVYYFLTAGMVWFVFLTYAWH--WRAMGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVD 405
            ||:|||.|.||:||||.||||||  ::|:|.....:..|.|||||:.||||.|||:..:|.::||
  Rat   322 FVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVD 386

  Fly   406 GNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHL 470
            |:|:.|||||||.|:..|||.:|.|:..|:::||||:.||::.||.:|.....:.|..|::||:.
  Rat   387 GDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINE 451

  Fly   471 IIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSVF-----EEKSSCRIENR 530
            .::|:|:...|...|:|:..:||..:|.:..||.:|||.:::|:.:...     :....|.|:||
  Rat   452 TMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNR 516

  Fly   531 PSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAKRK 595
            ||:.|.:::|..:|.:||.||||.||.:::..|:|...:..|....|..::.|.|:||:.::||:
  Rat   517 PSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRR 581

  Fly   596 D-FEDKGR-LSITLYN-THTDPV-GLNFDVNDLNSSETNDISSTWAAYLPQCVKRRMALTGAATG 656
            : .::.|: ||.:::. :|..|| ||.|::|:.::    |:||.||.::.:.|.||.|:      
  Rat   582 ELLQNPGQELSFSMHTVSHDGPVAGLAFELNEPSA----DVSSAWAQHVTKMVARRGAI------ 636

  Fly   657 NSSSHGPRKNSLDSEISVS--VRHVSVESRRN--SVDSQVSVKIAEMKTKVASRSRGKHGGSSSN 717
                       |..::||:  ...|..|.:.|  .|::::|.::.            |..|....
  Rat   637 -----------LPQDVSVTPVATPVPPEEQANLWLVEAEISPELE------------KRLGRKKK 678

  Fly   718 RRTQRR 723
            ||.:::
  Rat   679 RRKRKK 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 57/135 (42%)
7tmF_SMO_homolog 245..568 CDD:320158 148/329 (45%)
TM helix 1 254..279 CDD:320158 8/24 (33%)
TM helix 2 289..310 CDD:320158 11/20 (55%)
TM helix 3 340..366 CDD:320158 19/27 (70%)
TM helix 4 382..398 CDD:320158 11/15 (73%)
TM helix 5 420..449 CDD:320158 12/28 (43%)
TM helix 6 471..498 CDD:320158 7/26 (27%)
TM helix 7 529..554 CDD:320158 12/24 (50%)
SmoNP_036939.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..61
CRD_SMO 70..200 CDD:143560 57/135 (42%)
7tmF_SMO_homolog 224..554 CDD:320158 148/329 (45%)
TM helix 1 233..258 CDD:320158 8/24 (33%)
TM helix 2 268..289 CDD:320158 11/20 (55%)
TM helix 3 319..345 CDD:320158 18/25 (72%)
TM helix 4 363..379 CDD:320158 11/15 (73%)
TM helix 5 401..430 CDD:320158 12/28 (43%)
TM helix 6 452..479 CDD:320158 7/26 (27%)
TM helix 7 515..540 CDD:320158 12/24 (50%)
Interaction with BBS5 and BBS7. /evidence=ECO:0000250|UniProtKB:P56726 542..573 7/30 (23%)
Required for interaction with PRKACA. /evidence=ECO:0000250|UniProtKB:P56726 574..657 27/103 (26%)
Interaction with DLG5. /evidence=ECO:0000250|UniProtKB:P56726 585..597 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 674..702 3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

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