DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smo and sfrp-1

DIOPT Version :9

Sequence 1:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster
Sequence 2:	NP_500977.2	Gene:	sfrp-1 / 177401	WormBaseID:	WBGene00022242	Length:	314	Species:	Caenorhabditis elegans

Alignment Length:	148	Identity:	33/148 - (22%)
Similarity:	54/148 - (36%)	Gaps:	31/148 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 RCYPTSNATNTCFG-----SKLPYELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLC 148
            :|....:..:.|.|     .:||      ::.:..|..|......|:.:|..: .|....|.|||
Worm    36 KCVDIPSNLSICNGIEYTQMRLP------NILEHETVSEAIHASKDWESLLRL-NCHPDTQRFLC 93

  Fly   149 AVFKPKCEKINGEDMVYLPSYEMCRITMEPC-RILYNTTF-FPKFLRCNETLFPTKCTNGARGMK 211
            ::|.|.|  :...|.:.||...:|....:.| ..:.|..| :|:.|.|.               |
Worm    94 SLFAPVC--LMQMDRLILPCKSLCMAVKQGCENRMANYGFPWPEMLSCE---------------K 141

  Fly   212 FNGTGQCLSPLVPTDTSA 229
            |.....|:.|:.|....|
Worm   142 FEDDDMCIKPMQPAKPPA 159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	30/138 (22%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827
sfrp-1	NP_500977.2	CRD_FZ	37..161	CDD:382974	33/147 (22%)
sfrp-1	NP_500977.2	NTR_Sfrp1_like	162..283	CDD:239635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900