Protein Alignment smo and lin-17

DIOPT Version :10

• Sequence 1: NP_523443.1
• Gene: smo / 33196
• FlyBaseID: FBgn0003444
• Length: 1036
• Species: Drosophila melanogaster
• Sequence 2: NP_001021813.1
• Gene: lin-17 / 171832
• WormBaseID: WBGene00003006
• Length: 558
• Species: Caenorhabditis elegans
• Alignment Length: 547
• Identity: 133/547 - (24%)
• Similarity: 218/547 - (39%)
• Gaps: 103/547 - (18%)

  Fly    87 RARCYPTSNATNTCFGSKLPYELSSLDLTDFHTEKELNDKLNDYYALKHVPKCWAAIQPFLCAVF 151
            :.:|.|..  ...|  ..|||..:....|..|.::.......:::......||...|..|:|:||
 Worm    25 KGKCIPID--IELC--KDLPYNYTYFPNTILHNDQHTLQTHTEHFKPLMKTKCHPHIHFFICSVF 85

  Fly   152 KPKCEKINGEDMVYLPSYEMCRITMEPC-RILYNTTF-FPKFLRCNETLFPTKCTNGARGMKFNG 214
            .|.|.  .|..........:|......| .||..... :|:.|.|.:  ||.......:..:...
 Worm    86 APMCP--IGMPQAVTSCKSVCEQVKADCFSILEEFGIGWPEPLNCAQ--FPDPPELCMKPTEDEI 146

  Fly   215 TGQCLSPLVPTDTSASYYPGIEGC-----GVRCKDP------------LYTDDEHRQIHKLIGWA 262
            ||...:|.:||..|:|......||     .|...||            :::.|..|.:.....|.
 Worm   147 TGGFSAPRLPTKGSSSSSSKPTGCPSDLVDVDPHDPKSHCAFACQSNVMFSTDNKRMVRSWSIWF 211

  Fly   263 GSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWL--LQFTSGSREDIVCRKDGT 325
            .:......||...||.||.|.. ::|...|||::||..|:.:.:|  |...:..|.   |...|.
 Worm   212 AAANAGVALFSFLTFAIDRKRF-RFPERCVFYLSLCIFISSLPYLTPLFIDAPIRS---CHALGN 272

  Fly   326 LRHSEPTAG--ENLSCIVIFVLVYYFLTAGMVWFVFLTYAWH------WRAMGHVQDRIDKKGSY 382
            .| |..:.|  :|..|:..|:|.|:|.||..:|::..::..:      |     |.:.|:...||
 Worm   273 GR-SYLSIGTFDNSYCLASFLLNYFFSTAAALWWLMFSFTLYLSGGRKW-----VPEGIEACSSY 331

  Fly   383 FHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGP--LCGVI----LIGGY- 440
            .|.|||.|..:.||..:.|::||.:.:..:|.||.:|.......::.|  :|.||    ::||:
 Worm   332 VHFVAWGLSSLATIIVLIFNKVDASELTALCSVGNLNSIALLWFVIVPRTICIVIGTCFIVGGFA 396

  Fly   441 --------FITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMG-VCALLTLVFIL---VAIACH 493
                    |.|||                 :.::|:..::::|| .|||    |||   :.:.|.
 Worm   397 SMCRERISFRTRG-----------------TDTSKLEKLMVKMGFFCAL----FILPNVIELVCQ 440

  Fly   494 VTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSS---GIVMSTWCW 555
            ..:|....:|.   |..|.||     ::..:|   :||:....::::..:.||   |.....|..
 Worm   441 CYKFMILTQWT---RMTIDCK-----QQSGAC---HRPTPPQAEIYMTAVISSLATGFSCLMWVL 494

  Fly   556 TPSSIETWKRYIRKKCGKEVVEEVKMP 582
            :..::..||.:|  .||......||.|
 Worm   495 SAKTVHAWKNFI--FCGMCSSAPVKNP 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	29/135 (21%)
		7tmF_SMO_homolog	245..568	CDD:320158	89/366 (24%)
		TM helix 1	254..279	CDD:320158	5/24 (21%)
		TM helix 2	289..310	CDD:320158	8/22 (36%)
		TM helix 3	340..366	CDD:320158	7/31 (23%)
		TM helix 4	382..398	CDD:320158	8/15 (53%)
		TM helix 5	420..449	CDD:320158	10/43 (23%)
		TM helix 6	471..498	CDD:320158	9/30 (30%)
		TM helix 7	529..554	CDD:320158	5/27 (19%)
lin-17	NP_001021813.1	CRD_LIN_17	25..144	CDD:143563	27/126 (21%)
		7tmF_FZD4_9_10-like	194..507	CDD:320575	89/356 (25%)
		TM helix 1	203..228	CDD:320575	5/24 (21%)
		TM helix 2	237..258	CDD:320575	7/20 (35%)
		TM helix 3	288..314	CDD:320575	7/25 (28%)
		TM helix 4	331..347	CDD:320575	8/15 (53%)
		TM helix 5	369..399	CDD:320575	6/29 (21%)
		TM helix 6	418..445	CDD:320575	9/30 (30%)
		TM helix 7	468..493	CDD:320575	3/24 (13%)